A5074905444- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Porphyrin and Phthalocyanine Chemistry
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Brain Tumor Detection and Classification
- Molecular Biology Techniques and Applications
- Biosensors and Analytical Detection
- Drug Transport and Resistance Mechanisms
- Geotechnical Engineering and Underground Structures
- Pleural and Pulmonary Diseases
- Transportation Systems and Infrastructure
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Beetle Biology and Toxicology Studies
- Medicinal Plant Pharmacodynamics Research
- Advanced Biosensing Techniques and Applications
- Retinoids in leukemia and cellular processes
- Cannabis and Cannabinoid Research
- Respiratory viral infections research
- Pharmacological Effects of Natural Compounds
- Vascular Tumors and Angiosarcomas
- Traditional Chinese Medicine Analysis
- SARS-CoV-2 detection and testing
Glasgow Caledonian University
2022-2024
Tung Wah College
2014-2022
Hong Kong Polytechnic University
2006-2020
Tottori University Hospital
2019
Fudan University
2006
Photodynamic therapy (PDT) is a specific cancer treatment with minimal side effects. However, it remains challenging to apply PDT clinically, partially due the difficulty of translating research findings clinical settings as conventional 2D cell models used for in vitro are accepted less physiologically relevant solid tumour. 3D spheroids offer better model testing mechanisms and efficacy, particularly on photosensitizer uptake, cellular subcellular distribution interaction oxygen...
Nowadays, the ever-increasing costs of research and development in pharmaceutical industry have created a big demand for predicting performances drug candidates. Of those, desire to establish an vitro-in vivo correlation (IVIVC) better predict oral exposure different products is growing need. Once robust IVIVC established, performance can be predicted selected testing clinical trials with greater confidence. This tool will significantly reduce cost speed provide new therapy patient faster....
Background: Glioblastoma (GBM) is one of the most common malignant primary brain tumors, which accounts for 60–70% all gliomas. Conventional diagnosis and decision post-operation treatment plan glioblastoma mainly based on feature-based qualitative analysis hematoxylin eosin-stained (H&E) histopathological slides by both an experienced medical technologist a pathologist. The recent development digital whole slide scanners makes AI-based image feasible helps to diagnose cancer accurately...
Photodynamic Therapy (PDT) is a clinically approved cancer treatment. Sex hormones, the key drivers for development of female hormonal dependent cancers, might affect There are seldom studies to evaluate effect sex hormones mimicked menstrual cycle on PDT mediated by prodrug 5-aminolevulinic acid (ALA) and its ester derivatives cancers. To efficacy Hexyl-ALA-PDT in cancers heme biosynthetic pathway. Cell culture system that fluctuation 17β-estradiol (E2) progesterone (PG) was developed. Two...
Photodynamic therapy (PDT) is a novel therapeutic approach for combating various cancers. PDT involves the administration of photosensitizer which generates singlet oxygen after light activation. FosPeg Ⓡ liposomal formulation mTHPC. In this in vitro study, photodynamic efficacy on human colon cancer cell line (HT29) was investigated via studying cellular uptake , mediated photocytotoxicity and death mechanism were triggered. demonstrated its antitumor effect drug dose-dependent manner HT-29...
Background: MRI magnetization-prepared rapid acquisition (MPRAGE) is an easily available imaging modality for dementia diagnosis. Previous studies suggested that volumetric analysis plays a crucial role in various stages of classification. In this study, volumetry, radiomics and demographics were integrated as inputs to develop artificial intelligence model stages, including Alzheimer’s disease (AD), mild cognitive decline (MCI) normal (CN) classifications. Method: The Disease Neuroimaging...
There are seldom studies on the determination of cancer treatment efficacy related to normal hormonal tumor microenvironment triple negative breast (TNBC). This study aimed determine Hexyl-ALA-PDT TNBC in a simulated microenvironment. The 3D spheroids cells (MDA-MB-231) were generated supplemented accumulation PpIX, phototoxicity, ROS level and p-ULK1 expression mediated by determined confocal microscopy, MTT assay flow cytometry. A lower Hexyl-ALA concentration was required achieve same...
Recently, there is an increase in PDT studies using 3D spheroids. However, limited information demonstrating the effect of spheroid size on study. This study aims to provide NPC/CNE2 PpIX accumulation and efficacy. spheroids were generated with different initial cell densities (5,000-60,000 cells/well). Spheroids' diameter morphological characteristics recorded for 5 days post-PDT 24-72 hours. The intracellular was measured by Incucyte S3 live-cell analysis system. Spheroid increased density...