A5076526923- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Cell Adhesion Molecules Research
- Cell Image Analysis Techniques
- Immunodeficiency and Autoimmune Disorders
- Research on Leishmaniasis Studies
- Immune responses and vaccinations
- Advanced Fluorescence Microscopy Techniques
- CRISPR and Genetic Engineering
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Advanced biosensing and bioanalysis techniques
- COVID-19 Impact on Reproduction
- Diabetes and associated disorders
- Receptor Mechanisms and Signaling
- Phagocytosis and Immune Regulation
- Trypanosoma species research and implications
- Nicotinic Acetylcholine Receptors Study
Tsinghua University
2016-2025
Shanxi Medical University
2024-2025
Center for Life Sciences
2016-2025
China Rural Technology Development Center
2025
Peking University
2025
King Center
2022
Indiana University School of Medicine
2015
National Institute of Allergy and Infectious Diseases
2004-2011
National Institutes of Health
2004-2010
Shaanxi Normal University
2007
In contrast to naïve T cells that recognize short antigen-derived peptides displayed by specialized antigen-presenting cells, immunoglobulin receptors of B lymphocytes primarily intact proteins. How and where within a lymph node such unprocessed antigens become available for cell recognition is not clear. We used two-photon intravital imaging show that, after exiting high-endothelial venules before entry into follicles, survey locally concentrated dendritic cells. Engagement the receptor...
Follicular T helper (Tfh) cells highly express the programmed cell death-1 (PD-1) molecule. Whereas inhibition of receptor (TCR) signaling and CD28 co-stimulation is thought to be primary mode PD-1 functions, whether how regulates Tfh development function unclear. Here we showed that, when engaged by ensemble bystander B constitutively expressing ligand 1 (PD-L1), inhibited recruitment into follicle. This involved suppression PI3K activities downstream follicle-guidance CXCR5, was...
Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in deep tissue across multiple spatial and temporal scales to link diverse transient subcellular behaviors with long-term physiogenesis. Despite broad applications two-photon microscopy (TPM), there remains an inevitable tradeoff among spatiotemporal resolution, volumes, durations due the point-scanning scheme, accumulated phototoxicity, optical aberrations. Here, we harnessed concept synthetic aperture...
Inflammatory diseases are often chronic and recurrent, current treatments do not typically remove underlying disease drivers1. T cells participate in a wide range of inflammatory such as psoriasis2, Crohn's disease3, oesophagitis4 multiple sclerosis5,6, clonally expanded antigen-specific may contribute to chronicity recurrence, part by forming persistent pathogenic memory. Chronic rhinosinusitis asthma airway that present comorbidities7. affects more than 10% the general population8. Among...
Natural killer (NK) cells promote dendritic cell (DC) maturation and influence T differentiation in vitro. To better understand the nature of putative interactions among these vivo during early phases an adaptive immune response, we have used immunohistochemical analysis dynamic intravital imaging to study NK localization behavior lymph nodes (LNs) steady state shortly after infection with Leishmania major. In LNs naive mice, reside medulla paracortex, where they closely associate DCs....
In antibody responses, mutated germinal center B (B GC ) cells are positively selected for reentry or differentiation. As the products from GCs, memory and antibody-secreting (ASCs) support high-affinity long-lasting immunity. Positive selection of is controlled by signals received through cell receptor (BCR) follicular helper T (T FH cell–derived signals, in particular costimulation CD40. Here, we demonstrate that effector cytokine interleukin-21 (IL-21) joins BCR CD40 supporting reveal...
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and "anatomical escape" characteristics threaten the effectiveness current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand immunological mechanism broad-spectrum tract protection guide broader vaccines development. Here we investigate immune responses induced by NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides against SARS-CoV-2...