A5055046778- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Methane Hydrates and Related Phenomena
- Eosinophilic Esophagitis
- Marine and coastal ecosystems
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Traditional and Medicinal Uses of Annonaceae
- Genomics and Chromatin Dynamics
- Membrane Separation Technologies
- Chemical synthesis and alkaloids
- Herbal Medicine Research Studies
- Whipple's Disease and Interleukins
- Phytochemistry and biological activities of Ficus species
- Inflammatory Bowel Disease
- Pharmaceutical and Antibiotic Environmental Impacts
- Electrochemical sensors and biosensors
- DNA Repair Mechanisms
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Gut microbiota and health
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Medicinal Plants and Bioactive Compounds
Tsinghua University
2024-2025
BGI Group (China)
2021-2024
University of Chinese Academy of Sciences
2022-2024
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Qingdao University
2015
Jilin University
2015
Cordyceps militaris has been used extensively as a crude drug and folk tonic food in East Asia due to its various pharmacological activities. Our study aims investigate the effect of fruit body extract (CM) on antifatigue mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test running test. Compared nontreated mouse, increased ATP levels antioxidative enzymes activity reduced lactic acid, dehydrogenase,...
Mitochondrial supercomplexes are observed in mammalian tissues with high energy demand and may influence metabolism redox signaling. Nevertheless, the mechanisms that regulate supercomplex abundance remain unclear. In this study, we examined composition of derived from murine cardiac mitochondria determined how their changes substrate provision or by genetically induced to glucose-fatty acid cycle. Protein complexes digitonin-solubilized were resolved blue-native polyacrylamide gel...
•Intraepithelial lymphocytes (IELs) rapidly infiltrate into the crypt region upon chemotherapeutic drug 5-fluorouracil (5-FU)-induced intestinal damage.•IELs promote proliferation of transit-amplifying cells and epithelial regeneration.•CD160 from IELs mediates damage repair.•Engagement herpes virus entry mediator with CD160 is essential for regeneration. Chemotherapy radiotherapy frequently lead to damage. The mechanisms governing repair or regeneration are still not fully elucidated....
The ocean’s twilight zone is a critical where more than 70% of the sinking particulate organic carbon (POC) are remineralized. Therefore, determines size biological storage in ocean and regulates global climate.
The ethanol extract of the Ficus carica L. leaves was tested to show strong nematicidal activity against pine wood nematode (PWN), Bursaphelenchus xylophilus, causing 90.93% corrected mortality within 72 h at 1.0 mg/mL. From ethyl acetate soluble fraction F. extract, main constituents were obtained by bioassay-guided isolation and identified as linear furocoumarins bergapten (1) psoralen (2) mass NMR spectral data analysis. Bergapten had significant PWN with LC50 values 97.08 aKSnd 115.03 μ...
Temperature is a critical environmental factor that affects the cell growth of dinoflagellates and bloom formation. To date, molecular mechanisms underlying physiological responses to temperature variations are poorly understood. Here, we applied quantitative proteomic untargeted metabolomic approaches investigate protein metabolite expression profiles bloom-forming dinoflagellate
Background Previous studies have shown a coexistence phenomenon between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), but the causal relationship them is still unclear. Therefore, we conducted two-sample Mendelian randomization (MR) analysis using publicly available summary statistics data to evaluate whether there was two diseases. Methods Summary for SLE IBD were downloaded from Open Genome-Wide Association Study International Inflammatory Bowel Disease Genetics...
Understanding the mechanisms, structuring microbial communities in oligotrophic ocean surface waters remains a major ecological endeavor. Functional redundancy and metabolic tuning are two mechanisms that have been proposed to shape response environmental forcing. However, little is known about their roles due less integrative characterization of community taxonomy function. Here, we applied an integrated meta-omics-based approach, from genes proteins, investigate northern Indian Ocean....
Solubilized particulate organic matter (POM) rather than dissolved (DOM) has been speculated to be the major carbon and energy sources for heterotrophic prokaryotes in ocean. However, direct evidence is still lack. Here we characterized microbial transport proteins of POM collected from both euphotic (75 m, deep chlorophyll maximum DCM, 100 m) upper-twilight (200 m 500 zones three contrasting environments northwest Pacific Ocean using a metaproteomic approach. The proportion was relatively...
Abstract Intestinal lavage fluid (IVF) containing the mucosa‐associated microbiota instead of fecal samples was used to study gut using different omics approaches. Focusing on 63 IVF collected from healthy and hepatitis B virus‐liver disease (HBV‐LD), a question is prompted whether features could be extracted distinguish these samples. The IVF‐related derived data classified into two enterotype sets, whereas genomics‐based enterotypes were poorly overlapped with proteomics‐based one in...
Meiotic prophase I (MPI) is the most important event in mammalian meiosis. The status of chromosome-binding proteins (CBPs) and corresponding complexes their functions MPI have not yet been well scrutinized. Quantitative proteomics focused on MPI-related CBPs was accomplished, which mouse primary spermatocytes four different subphases were collected, chromosome-enriched extracted quantitatively identified. According to a stringent criterion, 1136 quantified. Looking at dynamic patterns CBP...