A5036665467- Topic Modeling
- Systemic Lupus Erythematosus Research
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- Aortic Disease and Treatment Approaches
- RNA modifications and cancer
- Natural Language Processing Techniques
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Anesthesia and Pain Management
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Identification and Quantification in Food
- T-cell and B-cell Immunology
- Mental Health via Writing
- Glycosylation and Glycoproteins Research
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Acupuncture Treatment Research Studies
- Psoriasis: Treatment and Pathogenesis
- Medical Research and Treatments
Second Affiliated Hospital of Zhejiang University
2013-2025
Southern University of Science and Technology
2024-2025
North Sichuan Medical University
2024-2025
Affiliated Hospital of North Sichuan Medical College
2025
Guangxi University
2023-2025
Energy Foundation
2018-2025
Anyang Hospital of Traditional Chinese Medicine
2024
South China Agricultural University
2024
Putian University
2024
Shandong University
2019-2024
An increasing body of evidence indicates that miR-149 can both suppress and promote tumor growth depending on the type. However, role in progression gastric cancer (GC) remains unknown. Here we report is a suppressor human cancer. expression decreased GC cell lines clinical specimens comparison to normal epithelial tissues, respectively. The levels also correlate with differentiation degree cells tissues. Moreover, ectopic inhibits proliferation cycle by down-regulating ZBTB2, potent...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
LAMP2A is the key protein of chaperone-mediated autophagy (CMA), downregulation leads to CMA blockade. activation has been implicated in cancer growth, but exact mechanisms are unclear. Elevated expression was found 8 kinds tumors (n=747), suggesting that may have an important role progression. Unsurprisingly, knockdown gastric (GC) cells hindered proliferation, accompanied with altered cell cycle-related proteins and accumulation RND3/RhoE. Interactomic KEGG analysis revealed RND3 a...
Non-alcoholic fatty liver disease (NAFLD) is a potentially serious that affects 30 % of the global population and poses significant risk to human health. However, date, no safe, effective appropriate treatment modalities are available. In recent years, ferroptosis has emerged as mode cell death been found play key regulatory role in development NAFLD. this study, we arbutin (ARB), natural antioxidant derived from Arctostaphylos uva-ursi (L.), inhibits onset ameliorates high-fat diet-induced...
Micronutrient malnutrition, especially zinc (Zn) and iron (Fe) deficiency in diets, has aroused worldwide attention. Biofortification of food crops been considered as a promising approach for alleviating this deficiency. Quantitative trait locus (QTL) analysis was performed to dissect the genetic mechanism Zn Fe content maize grains using total 218 F2:3 families derived from cross between inbred lines 178 P53. Meta-analysis used integrate maps detect Meta-QTL (MQTL) across several...
Many intracellular proteins are reversibly modified by O-linked GlcNAc (O-GlcNAc), a post-translational modification that dynamically regulates fundamental cellular processes in response to diverse environmental cues. Accumulating evidence indicates both excess and deficiency of protein O-GlcNAcylation can have deleterious effects on the cell, suggesting maintenance O-GlcNAc homeostasis is essential for proper function. However, mechanisms through which maintained physiologic state altered...
MicroRNAs play essential roles in gene expression regulation during carcinogenesis. Here, we investigated the role of miR-7 and mechanism by which it is dysregulated gastric cancer (GC). We used genome-wide screenings identified RELA FOS as novel targets miR-7. Overexpression repressed prevented GC cell proliferation tumorigenesis. These effects were clinically relevant, low was correlated with high poor survival patients. Intriguingly, found that indirectly regulated activation targeting...
Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms renal tubular epithelial cell survival important for prevention of kidney failure associated with glucotoxicity. Autophagy cellular pathway involved in protein organelle degradation. It many types homeostasis human diseases. To date, little known association between high concentrations glucose autophagy cells. In present study, we investigated glucose-induced toxicity...
Abstract Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies addition anti-cardiolipin (aCL) and lupus anticoagulant (LAC), some individuals with clinical features of APS remain seronegative (seronegative or SNAPS) are at risk recurrent thrombosis pregnancy morbidities. Our aim was assess value “non-criteria” aPL detect these SNAPS patients. Methods One hundred ninety-two patients,...
O-GlcNAc transferase (OGT) is the only enzyme in mammals that catalyzes attachment of β-D-N-acetylglucosamine (GlcNAc) to serine or threonine residues target proteins. Hyper-O-GlcNAcylation becoming increasingly realized as a general feature cancer and contributes rapid proliferation cells. In this study, we demonstrated OGT levels were increased all six gastric (GC) cell lines compared with immortal epithelial Downregulation O-GlcNAcylation level by silencing inhibited viability growth rate...
An increase in interleukin (IL)-17A-producing cells, particularly at sites of tissue inflammation, is observed frequently, yet the mechanism not fully understood. This study aims to dissect role IL-17 autoimmunity-mediated neuroinflammation. The cytokine milieu containing elevated IL-17, which often appears active states autoimmunity, was mimicked vitro by a supernatant obtained from rat peripheral blood monocytes stimulated with phorbol mystistate acetate (PMA)/ionomycin. application such...
Lysine acetylation has recently emerged as an important post-translational modification in diverse organisms, but relatively little is known about its roles mammalian development and stem cells. Bromodomain- PHD finger-containing protein 1 (BRPF1) a multidomain histone binder master activator of three lysine acetyltransferases, MOZ, MORF HBO1, which are also KAT6A, KAT6B KAT7, respectively. While the MOZ genes rearranged leukemia, gene mutated prostate other cancers four genetic disorders...
MGd1, a monoclonal antibody raised against gastric cancer cells, possesses high degree of specificity for (GC). Here we identified that the antigen MGd1 is CEACAM5, and used to investigate expression CEACAM5 in non-GC GC tissues (N=643), as biomarker prewarning prognosis. The was detected by immunohistochemistry numerous tissues; its clinicopathological correlation statistically analyzed. increased progressively from normal mucosa chronic atrophic gastritis, intestinal metaplasia, dysplasia...
Natural drug research is one of the main directions for discovery and development new drugs. Underutilized vegetables with a rich source medicinal value have drawn much attention from scientists in synthesizing drugs finding pharmacological actions. Apigenin natural flavonoid effects including anti-inflammatory, anti-tumor, anti-oxidation, anti-radiation, antidepressant effect, cardiovascular protection, regulated glucose lipid metabolism, protecting kidneys, neuroprotection, antibacterial,...
Empathetic conversation is psychologically supposed to be the result of conscious alignment and interaction between cognition affection empathy. However, existing empathetic dialogue models usually consider only affective aspect or treat in isolation, which limits capability response generation. In this work, we propose CASE model for It first builds upon a commonsense graph an emotional concept then aligns user's at both coarse-grained fine-grained levels. Through automatic manual...