A5031295186- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Digestive system and related health
- Cell Adhesion Molecules Research
- Developmental Biology and Gene Regulation
- Genetic factors in colorectal cancer
- Congenital heart defects research
- Renal and related cancers
- Autophagy in Disease and Therapy
- 3D Printing in Biomedical Research
- Pancreatic and Hepatic Oncology Research
- Connective Tissue Growth Factor Research
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Bioinformatics and Genomic Networks
- Liver physiology and pathology
- Cellular transport and secretion
- Bone Metabolism and Diseases
- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
Tsinghua University
2016-2025
Center for Life Sciences
2016-2025
Nanchang University
2022-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
King Center
2018-2024
Guangzhou Experimental Station
2022-2024
Peking University
2005-2024
Sanya University
2022-2024
Hainan Provincial Academy of Agricultural Sciences
2022-2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2019-2021
The intestine plays an important role in nutrient digestion and absorption, microbe defense, hormone secretion. Although major cell types have been identified the mouse intestinal epithelium, type–specific markers functional assignments are largely unavailable for human intestine. Here, our single-cell RNA-seq analyses of 14,537 epithelial cells from ileum, colon, rectum reveal different absorption preferences small large intestine, suggest existence Paneth-like identify potential new marker...
Abstract The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5 + stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of epithelium, but exact mechanism remains elusive. Here we demonstrate epithelial BMP plays an indispensable role in restricting cell expansion to maintain homeostasis and prevent premalignant on damage. Mechanistically, inhibits stemness...
Signal transduction by the TGF-β family involves sets of receptor serine/threonine kinases, Smad proteins that act as substrates, and Smad-associated transcription factors target specific genes. We have identified discrete structural elements dictate selective interactions between receptors Smads in BMP pathways. A cluster four residues L45 loop type I kinase domain, a matching set two L3 carboxy-terminal domain establish specificity receptor–Smad interactions. highly exposed α-helix 2...
The Smad proteins mediate transforming growth factor–β (TGFβ) signaling from the transmembrane serine-threonine receptor kinases to nucleus. anchor for activation (SARA) recruits Smad2 TGFβ receptors phosphorylation. crystal structure of a MH2 domain in complex with Smad-binding (SBD) SARA has been determined at 2.2 angstrom resolution. SBD, an extended conformation comprising rigid coil, α helix, and β strand, interacts sheet three-helix bundle Smad2. Recognition between coil is essential...
Smad7 plays an essential role in the negative-feedback regulation of transforming growth factor beta (TGF-beta) signaling by inhibiting TGF-beta at receptor level. It can interfere with binding to type I receptors and thus activation receptor-regulated Smads or recruit E3 ubiquitin ligase Smurf target them for degradation. Here, we report that is predominantly localized nucleus Hep3B cells. The targeted expression conferred superior inhibitory activity on signaling, as determined reporter...
Lung morphogenesis is a well orchestrated, tightly regulated process through several molecular pathways, including TGF-β/bone morphogenetic protein (BMP) signaling. Alteration of these signaling pathways leads to lung malformation. We investigated the role Follistatin-like 1 (Fstl1), secreted follistatin-module–containing glycoprotein, in development. Deletion Fstl1 mice led postnatal lethality as result respiratory failure. Analysis mutant phenotype showed that essential for tracheal...
TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer tissue fibrosis. is tightly regulated at different levels along the pathway, modulation receptor activity a critical step for regulation. This review focuses on our recent understanding regulation activity.
Severe acute respiratory syndrome (SARS) is an infectious disease with significant mortality. A typical clinical feature associated SARS pulmonary fibrosis and the lung failure. However, underlying mechanism remains elusive. In this study, we demonstrate that SARS-associated coronavirus (SARS-CoV) nucleocapsid (N) protein potentiates transforming growth factor-β (TGF-β)-induced expression of plasminogen activator inhibitor-1 but attenuates Smad3/Smad4-mediated apoptosis human peripheral...