A5100730345- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Effects of Radiation Exposure
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Gastric Cancer Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Radiation Detection and Scintillator Technologies
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Esophageal Cancer Research and Treatment
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Rabies epidemiology and control
- Radiomics and Machine Learning in Medical Imaging
Ministry of Agriculture and Rural Affairs
2022-2024
Lanzhou University
2010-2024
Northeastern University
2024
He Eye Hospital
2024
Chinese Academy of Sciences
2020-2024
Guangdong Academy of Agricultural Sciences
2012-2024
University of Chinese Academy of Sciences
2021-2024
Institute of Modern Physics
2020-2024
University of Wisconsin Carbone Cancer Center
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector lineages and stability vivo, we developed analyzed new Bcl6 reporter mouse alone or together lineage systems. Assisted genome-wide transcriptome analysis, show substantial plasticity of differentiation the early phase immune response. At this stage, CXCR5 appears to be expressed Bcl6-independent...
Schisandra chinensis, as a Chinese functional food, is rich in unsaturated fatty acids, minerals, vitamins, and proteins. Hence, this study was intended to elucidate the effects biological mechanism of Schisandrin A from chinensis DN. C57BL/6 mice were fed with high-fat diet then injected streptozotocin (STZ). Human renal glomerular endothelial cells stimulated 20 mmol/L d-glucose for DN model. presented acute kidney injury reduced oxidative stress inflammation model high glucose-induced...
The deubiquitinase USP25 prevents excessive proinflammatory signaling by Toll-like receptor 4.
T helper 17 (TH17) cells and interleukin-17A (IL-17A) produced by them are critical in autoinflammatory diseases, such as psoriasis. IL-17A has been shown to signal through IL-17 receptor A/IL-17 C (IL-17RA/IL-17RC) complex drive inflammatory responses. However, a psoriasis model, we found that Il17rc deficiency did not completely ameliorate the disease, suggesting another receptor. In search for IL-17A-interacting receptor, IL-17RD directly bound but IL-17F or IL-17A/F heterodimer formed...
Resveratrol (RSV) is known to play a role of anti-TNF-α in number cell types. However, whether RSV modulates the effects TNF-α on human nucleus pulposus (NP) cells unknown. The purpose this study investigate regulates TNF-α-induced matrix metalloproteinase-3 (MMP-3) expression. Via quantitative real-time polymerase chain reaction (qRT-PCR) analysis, we found that MMP-3 expression induced by was inhibited treatment. Depending Western blot and qRT-PCR assay, autophagy NP cells, whereas...
Ulcerative colitis (UC) is a chronic inflammatory disease with increasing incidence and prevalence in many countries. The purpose of this study to explore the function Schisandrin B its underlying molecular mechanisms colitis. In study, mice were induced by giving 2.0% dextran sulfate sodium (DSS, MP) drinking water for seven days. Furthermore, TCMSP server GEO DataSets used analyze mechanism It was found that presented model. At same time, not only reduced inflammation vivo vitro model...
Abstract Background The Arc two-component system is a global regulator controlling many genes involved in aerobic/anaerobic respiration and fermentative metabolism Escherichia coli . Shewanella oneidensis MR-1 contains gene encoding putative ArcA homolog with ~81% amino acid sequence identity to the E. protein but not full-length arcB gene. Results To understand role of S. , an arcA deletion strain was constructed subjected both physiological characterization microarray analysis. Compared...
Transforming growth factor–β (TGF-β) regulates reciprocal regulatory T cell (T reg) and helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator TGF-β signaling associates with Smad2, proinflammatory function Th17 cells. Trim33 deficiency in cells ameliorated an autoimmune disease vivo. was required for induction vitro Th17, but reg Moreover, Smad4 play contrasting roles regulation...
Abstract Epigenetic regulation is important for T-cell fate decision. Although STAT3 known to initiate Th17 differentiation program, the downstream mechanism unclear. Here we show that Tripartite motif containing 28 ( Trim28 ) expression in cells required Th17-mediated cytokine production and experimental autoimmune diseases. Genome-wide occupancy analysis reveals TRIM28-bound regions overlap with almost all Th17-specific super-enhancers (SE), those SEs are impaired by deficiency of or...
Canine distemper virus (CDV) is a highly contagious that causes multi-systemic, sub-clinical to fatal diseases in wide range of carnivore species. Based on the sequences haemagglutinin (H) gene, CDV strains have been classified into 18 major genetic lineages. In this study, we characterized genomes isolated from lungs two dead red pandas China. Histopathological and immunohistochemical analyses revealed damage due viral infection these lungs. The showed deep distance other recognized...
MoS 2 /CoS hetero-nanostructures with an abundant 1T-MoS phase are grown on a cobalt-MOF, and they show high HER activity in both alkaline acidic media. Only 1.53 V is required to drive overall water splitting