A5100761584- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Oral microbiology and periodontitis research
- Medical Education and Admissions
- Wound Healing and Treatments
- Urticaria and Related Conditions
- Drug Transport and Resistance Mechanisms
- Periodontal Regeneration and Treatments
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Biochemical Acid Research Studies
- dental development and anomalies
- Bone and Joint Diseases
- Whipple's Disease and Interleukins
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
Jeonbuk National University
2013-2025
Chungbuk National University
2012-2024
The University of Texas MD Anderson Cancer Center
2012-2018
Korea University
2015
Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt+ Treg the gut regulate intestinal inflammation by inhibiting effector T cell function. In current study, we report were also found lymph nodes following immunization. Not only distinct from transcriptomes, peripheral derived Foxp3+ thymic an antigen-specific manner. Development of these cells, coined regulatory 17 (Tr17) depended on IL-6/Stat3 signaling....
Abstract IL-9 is a proallergic cytokine produced by newly proposed Th cell subset, Th9. Th9 cells can be generated treatment of naive T with TGF-β and IL-4 in vitro. However, it still not clear how signaling regulates differentiation. In this study, we demonstrate that Smad2 Smad4, two transcriptional factors activated signaling, are required for differentiation Deficiency or Smad4 resulted impaired expression, which was coincident enrichment repressive chromatin modification histone H3 K27...
Abstract The periodontal ligament (PDL) is a connective tissue, and PDL cells have potential to differentiate into cementoblasts, osteoblasts, gingival fibroblasts. This study investigated whether transcription factor c‐Myb could induce differentiation of for regeneration. were isolated from extracted teeth cultured. was transfected using replication‐deficient adenoviral vector. Differentiation the analyzed by immunoblot, alkaline phosphatase activity, Alizarin red stain, immunofluorescence...
Abstract Objective This study evaluated whether hypoglycemic drug metformin enhances the anti-cancer effects of cisplatin in YD-9 cells. Methodology cells, derived from oral mucosal squamous cell carcinoma mucosa, were used to assess combined and by means MTT assay, live dead staining, colony formation assays evaluate viability proliferation. Reactive oxygen species level was measured using a Muse analyzer. Apoptosis, epithelial-mesenchymal transition, related molecular pathways analyzed...
Thermal burn injury induces inflammatory cell infiltrates in the dermis and thickening of epidermis. Following a injury, various mediators, including reactive oxygen species (ROS), are produced macrophages neutrophils, exposing all tissues to oxidative injury. The anti-oxidant activities flavonoids have been widely exploited scavenge ROS. In this study, we observed that several flavonoids-kaempferol, quercetin, fisetin, chrysin-inhibit LPS-induced IL-8 promoter activation RAW 264.7 cells....
Phenomenon: Medical ethics and professionalism are fundamental competencies for all physicians, resident physicians have to develop these during their training. Although Korea has a reputation having the highest quality medical practice in East Asia, improvements technological aspects of care outpaced developments institutional systems education needed fulfill social responsibility. Enhancing postgraduate training requires thorough exposition this situation. Approach: Twenty residents from...
CpG-DNA activates the host immune system to resist bacterial infections. In this study, we examined protective effect of in mice against Escherichia coli (E. coli) K1 infection. Administration increased survival after E. infection, which reduces numbers bacteria organs. Pre-injection with before infection levels complement C3 but not C3a and C3b. The was significantly decreased when were pre-injected cobra venom factor (CVF) removing compared non-CVF-treated group. It suggests that has roles...
Paxlovid is the first approved oral treatment for coronavirus disease 2019 and includes nirmatrelvir, a protease inhibitor targeting main (M
The ubiquitin-proteasome system is a major proteolytic for nonlysosomal degradation of cellular proteins. Here, we investigated the response mouse embryonic stem (ES) cells under proteotoxic stress. Proteasome inhibitors induced expression heat shock protein 70 (HSP70) in concentration- and time-dependent manner, also apoptosis ES cells. Importantly, more apoptotic were observed compared with other somatic To understand this phenomenon, further HSP70 pluripotent cell markers. was...
Various Invariant NKT (iNKT) cell ligands have been shown as potent adjuvants in boosting T reactivates to antigens on professional APC. Non-professional APC, such cells, also co-expressing MHC class I and CD1d, unattractive vaccine carriers due their poor immunogenicity. Here, we report that cells well lymphoma can efficiently generate antigen-specific cytotoxic lymphocytes (CTL) responses mice vivo, when formulated present iNKT ligand α-galactosylceramide (αGC) surface CD1d. Vaccination...
The objective of this study was to investigate whether phelligridin D could reduce glucose-induced oxidative stress, attenuate the resulting inflammatory response, and restore function human periodontal ligament cells (HPDLCs). Primary HPDLCs were isolated from healthy teeth cultured. To effect on treated with D, various concentrations glucose, glucose oxidase. Glucose-induced molecules, osteoblast differentiation, mineralization measured by hydrogen peroxide (H₂O₂) generation, cellular...