A5102975206- Gastroesophageal reflux and treatments
- Pregnancy and preeclampsia studies
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Pediatric health and respiratory diseases
- Eicosanoids and Hypertension Pharmacology
- Kruppel-like factors research
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Bacterial Genetics and Biotechnology
- T-cell and B-cell Immunology
- Dysphagia Assessment and Management
- Heavy Metal Exposure and Toxicity
- Matrix Theory and Algorithms
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Preterm Birth and Chorioamnionitis
- Mathematical functions and polynomials
Zhuzhou Central Hospital
2022-2025
Central South University
2023-2025
Kunming University of Science and Technology
2020-2024
First People's Hospital of Yunnan Province
2015-2024
Taihe Hospital
2022-2024
Third Hospital of Nanchang
2024
Hubei University of Medicine
2022-2024
Third Xiangya Hospital
2023-2024
Affiliated Hospital of Southwest Medical University
2017-2023
Third Affiliated Hospital of Zhengzhou University
2022-2023
Abstract Background Ovarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) secreted glycoprotein functions as regulator of cell metabolism and angiogenesis plays critical role in tumorigenesis. However, the precise ANGPTL4 OC microenvironment, particularly its involvement angiogenesis, has not been fully elucidated. Methods The expression was confirmed by bioinformatics IHC OC. potential molecular mechanism measured RNA-sequence. We...
Aloperine (ALO) is a quinolizidine alkaloid extracted from the leaves of Sophora alopecuroides (S. alopecuroides) and possesses anti-inflammatory, anti-allergenic, antitumor, antiviral effects. In this study, when compared with seven other types alkaloids S. alopecuroides, ALO treatment produced most potent effects against HCT116 colon cancer cell types. inhibited proliferation induced apoptosis in cells dose- time-dependent manner as detected by MTT, clonogenic survival, flow cytometric...
ABSTRACT Background and objective Statins have been widely used in inflammatory diseases including asthma, because of their anti‐inflammatory immunomodulatory properties. It has shown that simvastatin induces autophagy cell death some circumstances. However, the possible cross‐talk between autophagic processes lung disease is largely unknown. Thus, we investigated impact on airway inflammation remodelling relationship these to a simvastatin‐induced pathway mouse models asthma. Methods...
Hepatitis B virus (HBV) infection is a global public health problem that closely related to liver cirrhosis and hepatocellular carcinoma (HCC). The prevalence of acute chronic HBV infection, cirrhosis, HCC has significantly decreased as result the introduction universal vaccination programs. first hepatitis vaccine approved was developed by purifying surface antigen (HBsAg) from plasma asymptomatic HBsAg carriers. Subsequently, recombinant DNA technology led development vaccine. Although...
In neonatal intensive care unit infants referred for home-tube feeding methods, we evaluated the effect of an innovative diagnostic and management approach on outcomes at discharge 1 year, by comparing data from historical controls; hypothesized that clinical aerodigestive motility characteristics evaluation were predictive discharge; assessed economic impact outcomes.Patients (N = 100) who development long-term strategy 46.4 ± 13.1 weeks' postmenstrual age compared with 50 controls received...
Ovarian cancer (OC) is one of the most common types gynecologic tumor over world. The Glutathione S-transferase Mu (GSTM) has five members, including GSTM1-5. These GSTMs involved in cell metabolism and detoxification, but their role OC remains unknown.Data from multiple public databases associated with were collected. Expression, prognosis, function enrichment, immune infiltration, stemness index, drug sensitivity analysis was utilized to identify roles progression. RT-qPCR confirmed effect...
Abstract Context Insulin resistance is a feature of type 2 diabetes mellitus (T2DM). The estimated glucose disposal rate (eGDR), validated marker for insulin resistance, associated with complications diabetes, but few studies have explored the relationship between eGDR and renal outcomes in T2DM. Objective This study investigated value predicting progression Methods A total 956 T2DM patients baseline glomerular filtration (eGFR) ≥ 60 mL/min/1.73 m2 5 years follow-up were enrolled. Primary...
Preeclampsia (PE) is a severe pregnancy complication characterized by significant alterations in coagulation function. This study aims to analyze the correlation between function, platelet parameters, and outcomes PE patients. Clinical data, along with blood urine samples, were collected from 168 patients 128 healthy pregnant women. General demographic laboratory testing data recorded, maternal fetal followed up. Data analyzed using Kaplan-Meier logistic regression analyses. In mild...
To explore the clinical significance of 26 circulating tumor DNA (ctDNA) associated with multiple myeloma (MM) in peripheral blood new diagnosed patients. We conducted a study to detect ctDNA mutations 31 newly (NDMM) Among NDMM patients, detection rate was 93.55%, significantly higher than that FISH and chromosome screening methods. The most frequently mutated genes were ACTG1 GNAS. Notably, exclusive furthermore, resulted from missense mutation exon 4. gene co-mutated others. All patients...
Abstract Background: The relationship between oocyte morphology and developmental potential has been a hot research topic in assisted reproductive technology (ART). Whether inclusions the perivitelline space (PVS) affect ART outcomes remains controversial. Case Presentation: We present case report of 34-year-old G3P1A2 woman who sought treatment because sequelae pelvic disease. As her husband had severe oligospermia due to stress on day retrieval, intracytoplasmic sperm injection (ICSI) was...
We defined the sensory-motor characteristics of lower esophageal sphincter relaxation (LESR) (stimulus threshold volume, response onset, and period, magnitude, nadir) during maturation in human neonates. hypothesized that LESR kinetics differs with peristaltic reflex type. Basal adaptive motility testing was performed (N = 20 premature neonates) at 34.7 39.1 wk (time 1 time 2). Effects midesophageal provocation graded stimuli 1,267 stimuli, air liquids) on esophagodeglutition (EDR) secondary...
BACKGROUND: The gut microbiota plays an important role in human health. It is essential to understand how the composition of neonates established. OBJECTIVES: To investigate nature microbial community first feces newborn infants compared with mothers’ placentae and vaginas. METHODS: One infant who was delivered via Cesarean section vaginally. Bar‐coded pyro‐sequencing 16S ribosomal RNA genes used bacterial structure each site. RESULTS: Neonatal both had similar communities, they were...
The aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family, has recently been demonstrated to regulate T cell differentiation. Whether AhR activation participates in allergic airway inflammation remains unknown. In current study, using non-eosinophilic asthma model, we demonstrate that 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin (TCDD), potent ligand, reduced infiltration neutrophils, hyperresponsiveness and Th17 cytokine expression. Furthermore, stimulation with TCDD...