A5068420671- Cholangiocarcinoma and Gallbladder Cancer Studies
- Retinal Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Muscle metabolism and nutrition
- Glaucoma and retinal disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Retinal Development and Disorders
- Coffee research and impacts
- Exercise and Physiological Responses
- Acute Myocardial Infarction Research
- Adenosine and Purinergic Signaling
- Tea Polyphenols and Effects
- Peptidase Inhibition and Analysis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Photoacoustic and Ultrasonic Imaging
- Neurosurgical Procedures and Complications
- Cancer Mechanisms and Therapy
- Hedgehog Signaling Pathway Studies
- Eicosanoids and Hypertension Pharmacology
- Antimicrobial Peptides and Activities
- Renin-Angiotensin System Studies
Shanghai University of Sport
2024
Hubei University
2024
Xiangya Hospital Central South University
2023
Central South University
2023
Affiliated Hospital of Southwest Medical University
2017-2022
Jackson Laboratory
2014-2022
University of Taipei
2022
Capital Medical University
2016-2019
University of California, Los Angeles
2017
Huazhong Agricultural University
2013
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and activation its signal pathway plays an important role in regulating growth synthesis as well cell proliferation survival. In the present study, we examined contribution mTOR downstream products to brain injuries induced by intracerebral hemorrhage (ICH) rats.Western Blot analysis was employed examine expression Caspase-3. ELISA used measure pro-inflammatory cytokines (PICs) vascular endothelial factor (VEGF)....
Objective: Obesity/metabolic syndrome and hyperuricemia are clinically associated; however, the association of obesity/metabolic syndrome-related genetic variants with is not clear. Therefore, we assessed this in Chinese men diagnosed comparison to a non-hyperuricemia group. Methods: We genotyped 47 single nucleotide polymorphisms (SNPs) previously identified be associated obesity or metabolic 474 adult males (aged ≥ 18 years) using multiplex polymerase chain reaction. Multivariate logistic...
The conventional chemotherapy agent, doxorubicin, is of limited clinical use because its systemic toxicity toward normal healthy tissue. A new doxorubicin conjugate with α-linolenic acid showed good anti-tumor activity lower than free and exhibited an active tumor-targeting profile due to the introduction which might be effective moiety for modification chemotherapeutics.
Caffeinated energy drinks are commonly taken to improve exercise performance, but there few studies on the influence of different doses an athlete's performance. We conducted a double-blind, randomized, counter-balanced, and crossover research study examine effects low caffeinated drink (Low ED) or high (High supplement haematological response, oxidative stress in triathletes. Twelve male participants underwent three testing sessions separated by weekly intervals, consisting sprint triathlon...
The study objective was to observe the treatment effect of farnesoid X receptor (FXR) agonist GW4064 in a rat model hilar cholangiocarcinoma explore new therapeutic target for gene therapy cholangiocarcinoma. Eighty male Wistar rats were randomly divided into four groups (treatment group, control group and sham operation 20 each group). fed standard diet. injected with suspension QBC939 cells bile duct microsyringe, normal saline, not anything. A modified tail test (TST) used evaluate...
Chediak–Higashi syndrome, caused by mutations in the Lys osome T rafficking Regulator ( Lyst ) gene, is a recessive hypopigmentation disorder characterized albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of lysosomes lysosome-related organelles. Although recent studies have suggested that impair regulation sizes lysosome organelle, underlying pathogenic mechanism syndrome still unclear. Here we show striking evidence deficiency LYST protein...
Develop a rat model of hilar cholangiocarcinoma for detecting bile salt export pump (Bsep) expression in tissues, order to provide new therapeutic target the gene therapy cholangiocarcinoma. Sixty male Wistar rats (body weight, 190 ± 8 g) were randomly divided into three groups (the experimental group, control group and sham operation n = 20 each) as follows: The fed standard diet, was injected by QBC939 cell suspension along duct bifurcation with microsyringe, normal saline, did not inject...
Background: The study aims to detect the expression of Na + /taurocholate cotransporter polypeptide in hilar cholangiocarcinoma rat model, provide a new therapeutic target for gene therapy cholangiocarcinoma. Methods: 60 male Wistar rats (weighing 190 ± 8 g) were randomly divided into 3 groups (experimental group, control and sham operation group; 20 each group). fed with standard diet. QBC939 cell suspension was injected bile duct experimental group micro syringe. normal saline, not any...
Introduction High-intensity interval training (HIIT) has been shown to improve chronic diseases. Probiotics have found similar effects. However, the additive effects of HIIT in combination with probiotics supplementation are unclear. The aim current study was investigate whether there were when implementing both and simultaneously.
The study objective was to detect the expression of farnesoid X receptor (FXR) in a rat model hilar cholangiocarcinoma provide new therapeutic target for gene therapy cholangiocarcinoma. Sixty male Wistar rats (weighing 190 ± 8 g) were randomly divided into three groups (experimental group, control group and sham operation 20 each group). fed standard diet. QBC939 cell suspension injected bile duct experimental with microsyringe. normal saline, not any drugs. A modified tail test (TST) used...
Preclinical studies have shown that the combination of quercetin (Q) and green tea (GT) extract enhanced anti‐carcinogenic activity in a prostate cancer xenograft model, increased bioavailability GT polyphenols (P) decreased P methylation compared to alone. In order test hypothesis humans Q with would enhance GTP consumption alone we enrolled 32 men diagnosed randomized them receive 2 capsules (240 mg) either 1 capsule (400 (GT+Q) or placebo (GT+PL) two times per day prior prostatectomy....
Congenital Disorders of Glycosylation (CDG) are a heterogenous group primarily autosomal recessive mendelian diseases caused by disruptions in the synthesis lipid linked oligosaccha-rides and their transfer to proteins. CDGs affect multiple organ systems vary presentation, even within families. Here we describe chemically induced mouse mutant, tvrm76, with early onset photoreceptor degeneration. The mutation was mapped Chromosome 9 as-sociated missense Dpagt1 gene encoding...
Objective To investigate the correlation between cardiac structure, function and high sensitivity troponin T (hs-cTnT) in elderly hospitalized patients. Methods In this cross-sectional study, 343 non- acute coronary syndrome (ACS) patients aged 65 years older were enrolled from May 2014 to 2015, including 251 males 92 females with a mean age of 82.1 ± 6.5 old.Blood hs-cTnT concentrations was tested echocardiography performed measure left ventricular end dilated diameter (LVEDD),...