Organometallic ruthenium(II) arene anticancer complexes of the type [(η6-arene)Ru(II)(en)Cl][PF6] (en = ethylenediamine) specifically target guanine bases DNA oligomers and form monofunctional adducts (Morris, R., et al. J. Med. Chem. 2001). We have determined structures "piano-stool" [(η6-Bip)Ru(II)(en)Cl][PF6] (1, Bip biphenyl), [(η6-THA)Ru(II)(en)Cl][PF6] (2, THA 5,8,9,10-tetrahydroanthracene), [(η6-DHA)Ru(II)(en)Cl][PF6] (3, DHA 9,10-dihydroanthracene) with derivatives, in solid state by...

Abstract The aqua adducts of the anticancer complexes [(η 6 ‐X)Ru(en)Cl][PF ] (X=biphenyl (Bip) 1, X=5,8,9,10‐tetrahydroanthracene (THA) 2, X=9,10‐dihydroanthracene (DHA) 3; en=ethylenediamime) were separated by HPLC and characterised mass spectrometry as products hydrolysis in water. X‐ray structures ‐X)Ru(en)Y][PF n , X=Bip, Y=0.5 H 2 O/0.5 OH, =1.5 ( 4 ), X=THA, 5 A Y=H O, =2 B X=DHA, are reported. In complex there is a large propeller twist 45° pendant phenyl ring with respect to...

Advances in cancer therapy have increased the rate of survival young patients; however, female lymphoma patients frequently face a temporary or permanent loss fertility when treated with traditional cytotoxic agents. The potential is an important concern that can influence treatment decisions for many premenopausal patients. negative effect chemotherapeutic agents and protocols to patients' fertility–referred as fertotoxicity–are thus increasingly survivorship issue. We developed novel...

Organometallic chemistry offers novel concepts in structural diversity and molecular recognition that can be used drug design. Here, we consider DNA by η 6 -arene Ru(II) anticancer complexes an induced-fit mechanism. The stereochemistry of the dinuclear complex [((η -biphenyl)RuCl(en)) 2 -(CH ) ] + (3, en = ethylenediamine) was elucidated studies half unit [(η -biphenyl)RuCl(Et-en)] (2, where Et-en is Et(H)NCH CH NH ). structures separated \documentclass[12pt]{minimal} \usepackage{amsmath}...

Fuzi, the processed lateral roots of Aconitum carmichaelii Debx., is a traditional herbal medicine that well known for its excellent pharmacological effects and acute toxicity. Aconitine one diester-diterpene alkaloids well-known arrhythmogenic effects. However, aconitine in zebrafish have rarely been studied. Therefore, we investigated on embryos H9c2 cells. Zebrafish at 48 hours postfertilization were exposed to aconitine, then, cardiac function apoptosis measured. Through transcriptomic...

In oncology, clinical decision-making relies on a multitude of data modalities, including histopathological, radiological, and factors. Despite the emergence computer-aided multimodal systems for predicting hepatocellular carcinoma (HCC) recurrence post-hepatectomy, existing models often employ simplistic feature-level concatenation, leading to redundancy suboptimal performance. Moreover, these frequently lack effective integration with clinically relevant encounter challenges in integrating...

To explore the clinical significance of 26 circulating tumor DNA (ctDNA) associated with multiple myeloma (MM) in peripheral blood new diagnosed patients. We conducted a study to detect ctDNA mutations 31 newly (NDMM) Among NDMM patients, detection rate was 93.55%, significantly higher than that FISH and chromosome screening methods. The most frequently mutated genes were ACTG1 GNAS. Notably, exclusive furthermore, resulted from missense mutation exon 4. gene co-mutated others. All patients...

The collagen density is not detected in the patellar tendon (PT), posterior cruciate ligament (PCL), and anterior (ACL) clinic. We assess technical feasibility of three-dimension multiecho fat saturated ultrashort echo time cones (3D FS-UTE-Cones) acquisitions for single- bicomponent T2⁎ analysis bound free water pools PT, PCL, ACL knees five healthy volunteers six knee joint samples from cadavers were scanned via 3D FS-UTE-Cones on a clinical scanner. Single-component fitting T2⁎M short...

The 5 G/5 G genotype of PAI-1 polymorphism is linked to decreased plasminogen activator inhibitor-1 (PAI-1) levels and it has been suggested that lower may provide protective effects on inflammation, local microcirculatory disturbance, fibrotic changes, which are likely associated with development sudden sensorineural hearing loss (SSNHL).The association the 4 clinical outcome SSNHL evaluated via a case control study. 103 patients 113 age sex-matched controls were enrolled at University...

Objective. To develop and externally validate a CT-based radiomics nomogram for pretreatment prediction of relapse in osteosarcoma patients within one year. Materials Methods. In this multicenter retrospective study, total 80 (training cohort: 63 from three hospitals; validation 17 other hospitals) with osteosarcoma, undergoing CT between August 2010 December 2018, were identified databases. Radiomics features extracted selected tumor regions on image, then, the signature was constructed....

Percutaneous coronary intervention (PCI) has become one of the effective methods for treatment heart disease (CHD). However, it is easy to have in-stent restenosis (ISR), even cardiovascular events after PCI, which affects therapeutic effects. The incidence ISR in diabetes mellitus (DM) patients increased by 2 4 times. Early identification risk factors DM PCI may help clinical staff prevent and intervene as soon possible, so very important improve outcomes patients. Although scholars at home...

<h3>Background</h3> Identifying at-risk nonalcoholic steatohepatitis (defined as NASH and ≥ stage 2 fibrosis) in patients with NAFLD is critical. The steatosis-associated fibrosis estimator (SAFE) a novel non-invasive test designed to significant (F ≥2) the MR-MASH score an image biomarker proposed for predicting NASH. We aim evaluate 2-step approach combining SAFE scores <h3>Methods</h3> retrospectively analyzed 286 undergoing contemporaneous laboratory tests, MRI liver biopsy. SAFE, FIB-4,...

In this study,transcriptomics technique was used to investigate the mechanism of action Aconiti Lateralis Radix Praeparata on acute heart failure rats induced by propafenone hydrochloride.First,rats were randomly divided into normal group,model group and administration group(1.25,2.5,5 g·kg-1).A rat with constructed intravenous femoral proparone hydrochloride.The changes rate,+dp/dtmaxand-dp/dtmaxat 5,10,20,30 60 min recorded.Then another given same drug delivery method.In animals,serum...

Background: To develop and externally validate an MR-based radiomics nomogram from retrospective multicenter datasets for pretreatment prediction of early relapse (≤1 year) in osteosarcoma after surgical resection.Methods: This study retrospectively enrolled 93 patients (training cohort: 62 four hospitals; validation 31 two hospitals) with clinicopathologically confirmed who received neoadjuvant chemotherapy resection at six hospitals between January 2009 October 2017. Radiomics feature was...

To investigate the genetic results of whole exome sequencing bone marrow from new onset multiple myeloma (MM) patients to analyze process clonal evolution in MM patients.Genomic DNA was extracted samples 15 and exomes performed using next generation technology. Using own buccal cells as germline controls, combinated with clinical information, mutation profile genes high-risk asymptomatic symptomatic were analyzed, that may be associated efficacy side effects bortezomib screened.Except for...

Abstract Breast cancer (BC) is a heterogeneous disease comprising different clinical, histopathological, and molecular subtypes. Triple negative breast (TNBC) among the most aggressive clinical manifestations of (BC), represents significant challenge to effective treatment early metastatic treatment-refractory because its poor outcomes. Therefore, there exists need develop pre-clinical models that retain characteristics original TNBC tumor—e.g., PDX tumor models—to better understand...

With the development of e-commerce industry and improvement rural economic level, Internet consumption is booming. However, "last mile" distribution logistics facing problems imperfect infrastructure equipment construction, high cost, low efficiency. The problem has become biggest obstacle to logistics. idea drone truck cooperating in undoubtedly provides a new way solve In this paper, mathematical model established for vehicle routing which cooperate with each other areas. takes minimizing...

To compare the effects of direct fluorescence in situ hybridization (D-FISH) detection without sorting and CD138 immunomagnetic bead technology combined with FISH (MACS-FISH) on cytogenetic analysis patients multiple myeloma (MM).FISH test results 229 initial MM were retrospectively analyzed. The divided into two groups, 140 tested D-FISH 89 MACS-FISH. combination probe was designed as P53, D13S319, RB1, 1q21, IgH. Cytogenetic compared between groups.The total rate abnormalities group 52.9%,...

To study the expression and significance of PD-1, PD-L1 CTLA-4 tumor-associated antigens in multiple myeloma.Bone marrow specimens from 122 patients with myeloma were collected divided into new-onset group (NDMM), complete remission (CRMM) relapsed refractory (RRMM) according to disease progression stage. The proportion CD4+ T lymphocytes, CD8+ Treg cells plasma expressions detected by multi-parameter flow cytometry.There was no significant difference CD8+T among three groups (P>0.05), while...