A5100393482- Immune Cell Function and Interaction
- Trauma Management and Diagnosis
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Spinal Fractures and Fixation Techniques
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pelvic and Acetabular Injuries
- Research in Cotton Cultivation
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Trauma and Emergency Care Studies
- Lung Cancer Research Studies
- Cardiac Arrest and Resuscitation
- Transgenic Plants and Applications
- Salivary Gland Disorders and Functions
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
- Shoulder and Clavicle Injuries
- Gut microbiota and health
- Renal and related cancers
Shanghai Sixth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Shanghai Chest Hospital
2014-2025
Beijing Tian Tan Hospital
2023-2025
Capital Medical University
2023-2025
Beijing University of Chemical Technology
2025
XinHua Hospital
2025
First Affiliated Hospital of Soochow University
2025
Zhengzhou University
2023-2025
Sun Yat-sen University
2013-2024
Gut microbiome affecting the responses to immune checkpoint inhibitors against advanced NSCLC has been investigated in Western population. However, considering pre-existing genetic and gut microbiota variation, relevance remains unknown East-Asian This study is designed explore relationship between clinical outcomes Chinese patients with who have received treatment using an anti-programmed death 1 (PD-1) blockade.Thirty-seven receiving nivolumab were enrolled CheckMate 078 (NCT02613507) 870...
Tumor metastasis involves a series of biological steps during which the tumor cells acquire ability to invade surrounding tissues and survive outside original site. During early stages, cancer undergo an epithelial-mesenchymal transition (EMT). Wnt/β-catenin signaling is known drive EMT metastasis. Here we report that hyperactivated in metastatic breast express microRNA 374a (miR-374a). In cell lines, ectopic overexpression miR-374a promoted both vitro vivo. Furthermore, directly targeted...
Abstract AKT signaling is constitutively activated in various cancers, due large part to loss-of-function the PTEN and PHLPP phosphatases that act as tumor suppressor genes. However, widely non–small cell lung cancers (NSCLC) where genetic alterations or genes are rare, suggesting an undefined mechanism(s) for their suppression. In this study, we report upregulation of oncomir microRNA (miR)-205 multiple subtypes NSCLC, which directly represses PHLPP2 expression activates both AKT/FOXO3a...
Branched-chain amino acids (BCAAs) provide nutrient signals for cell survival and growth. How BCAAs affect CD8+ T functions remains unexplored. Herein, we report that accumulation of in cells due to the impairment BCAA degradation 2C-type serine/threonine protein phosphatase (PP2Cm)-deficient mice leads hyper-activity enhanced anti-tumor immunity. from PP2Cm−/− upregulate glucose transporter Glut1 expression a FoxO1-dependent manner with more uptake, as well increased glycolysis oxidative...
Large-scale skin injuries are usually accompanied by impaired wound healing, resulting in scar formation, or significant morbidity and mortality. The aim of this study is to explore the vivo application 3D-printed tissue-engineered substitute using innovative biomaterial loaded with human adipose-derived stem cells (hADSCs) healing. Adipose tissue was decellularized, extracellular matrix components were lyophilized solubilized obtain adipose decellularized (dECM) pre-gel. newly designed...
Abstract The aim was to evaluate the effects of traditional Chinese medicine (TCM) as a combination medication with adjuvant chemotherapy on postoperative early stage non-small cell lung cancer (NSCLC) patients. 314 patients completely resected IB, II or IIIA cancers were assigned into vinorelbine plus cisplatin/carboplatin (NP/NC) (control, n = 158) and NP/NC additional TCM (intervention, 156) groups. primary endpoint QOL scores; secondary endpoints toxicity safety regimens. regimen caused...
Abstract Idiopathic pulmonary fibrosis (IPF) poses significant challenges due to limited treatment options despite its complex pathogenesis involving cellular and molecular mechanisms. This study investigated the role of transient receptor potential ankyrin 1 (TRPA1) channels in regulating M2 macrophage polarization IPF progression, potentially offering novel therapeutic targets. Using a bleomycin-induced model C57BL/6J mice, we assessed TRPA1 inhibitor HC-030031. upregulation was observed...
This study aim to evaluate surgical procedures for titanium plate internal fixation of sternal fractures with displacement or nonunion.From January 2010 December 2014, 64 patients were treated in the thoracic surgery department Shanghai Sixth People's Hospital. Pain severity scale scores analyzed preoperatively and postoperatively. All had a 2-month follow-up treatment evaluation.The mean hospital length stay was 16.89 days. Forty-five underwent combined injuries. A statistically significant...
Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering feasibility of sample collection, whether peripheral cell signatures are associated with ICI therapy remains unclear. Herein, we defined advanced non-small lung (NSCLC) patients receiving anti-PD-1 monotherapy investigated their associations clinical efficacy. It was found that percentages before treatment...
Early treatment and prevention are the keys to reducing mortality of VTE in patients with thoracic trauma. This study aimed develop validate an automatic prediction model based on machine learning for risk screening In this national multicenter retrospective study, clinical data chest trauma hospitalized 33 hospitals China from October 2020 September 2021 were collected training testing. The at Shanghai Sixth People's Hospital 2022 included further verification. performance was measured...
ABSTRACT The development and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in children are closely related to alterations gut microbiota. This study aims investigate changes the microbiota signature microbial metabolites with MASLD. We collected fecal samples from adolescents aged 6–16 years, presence MASLD was diagnosed by ultrasound. performed 16S ribosomal DNA sequencing targeted metabolomics 36 25 subjects, consisting healthy controls, obesity, α-diversity...
Abstract Background Tumor immune evasion extends beyond T cells, affecting innate elements like natural killer cells (NK) and macrophages within the tumor-immune microenvironment (TIME). Nevertheless, translational strategies to trigger collaboration of NK initiate sufficient anti-tumor cytoxicity remain scarce are urgently needed. Methods In this study, TCGA datasets was used confirm prognosis value expression level NLR family pyrin domain containing 4 (NLRP4) in NSCLC tumor tissues...
Paravertebral block (PVB) is commonly used for analgesia postoperatively while rarely as anesthesia during surgical stabilization rib fractures. This study aimed to explore the feasibility and safety of PVB alone patients with multiple fractures (MRF) under conscious state. prospective single-arm pilot was conducted in MRF who schedule using Shanghai Sixth People's Hospital Affiliated Jiao Tong University School Medicine between September 2019 2020. The outcomes were vital signs,...
Patients with Parkinson's disease (PD) exhibit an increased risk of melanoma, implying shared yet incompletely understood molecular mechanisms. This study aimed to delineate these common and distinct pathways by analyzing gene expression profiles from the Gene Expression Omnibus. A total 90 differentially expressed genes (DEGs) were commonly regulated, while 173 DEGs exhibited divergent regulation between PD melanoma. Protein-protein interaction analysis identified SNCA as a central node...
Abstract Relapse and disease progression are the primary causes of treatment failure subsequent mortality in children with B‐cell acute lymphocytic leukemia (B‐ALL). At diagnosis during treatment, dyslipidemia bone marrow adipose microenvironment commonly observed pediatric leukemia. However, intricate connection between these factors remains largely unexplored. We found that abnormal triglyceride accumulation increased risk death. Further investigation into adipogenic potential BM‐MSCs...
Transforming growth factor beta-inducing 1 (TGIF1) was reported to be dysregulated in several types of cancer. However, its expression pattern and functions nonsmall cell lung cancer (NSCLC) remained unknown. In the present study, TGIF1 found elevated clinical NSCLC tissues. promoted migration cells, while knocking down inhibited cells. Moreover, downregulation impaired metastasis study for molecular mechanisms, it that positively regulated beta-catenin/TCF signaling. summary, our...
Background: Primary Sjögren's syndrome (pSS) is a progressive inflammatory autoimmune disease. Immune cell infiltration into glandular lobules and ducts destruction are the pathophysiological hallmarks of pSS. Macrophages one most important cells involved in induction regulation an microenvironment. Although studies have reported that abnormal tissue microenvironment alters metabolic reprogramming polarisation status macrophages, mechanisms driving macrophage pSS remain unclear. Methods:...
This study aimed to determine the incidence and influencing factors of venous thromboembolism (VTE) in patients with traumatic rib fractures.