A5112122402- Plant Pathogens and Fungal Diseases
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Liver Disease Diagnosis and Treatment
- Mycorrhizal Fungi and Plant Interactions
- Plant and Fungal Species Descriptions
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- Machine Learning in Bioinformatics
- Liver physiology and pathology
- Trace Elements in Health
- Hedgehog Signaling Pathway Studies
- Tryptophan and brain disorders
- Respiratory viral infections research
- Amino Acid Enzymes and Metabolism
- Yeasts and Rust Fungi Studies
- Plant Disease Resistance and Genetics
- Renin-Angiotensin System Studies
- Marine Sponges and Natural Products
- Influenza Virus Research Studies
- Higher Education and Teaching Methods
- Cancer-related molecular mechanisms research
- Plant-Microbe Interactions and Immunity
Zunyi Medical University
2024-2025
Macau University of Science and Technology
2025
First People's Hospital of Yunnan Province
2008-2024
Ningxia Medical University General Hospital
2024
Ningxia Medical University
2024
Kunming University of Science and Technology
2013-2024
Shandong Agricultural University
2015-2016
Cornell University
2016
Kunming Medical University
2009-2013
National Institute for Viral Disease Control and Prevention
2004-2006
Abstract Background Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed CAR-T therapy. However, our prior study revealed challenges CAR-NK targeting CD19 antigens, as they failed to eliminate + Raji NSG tumor-bearing mice, noting down-regulation or loss of expression some cells. In response, this aims enhance efficacy and mitigate the risk tumor recurrence due target escape by developing CD20...
Abstract Current treatments for ulcerative colitis (UC) remain limited, highlighting the need novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti‐inflammatory properties. In this study, dextran sulfate sodium (DSS)‐induced animal model is used to investigate effects of TLB on UC. It found significantly alleviates DSS‐induced UC in mice, as evidenced by reduction disease activity index, an increase colon length, improvement...
Abstract Background Epimedii Folium, first recorded in the Shennong’s Classic of Materia Medica ( Shen Nong Ben Cao Jing ), is a traditional Chinese medicine (TCM) known for its effects “benefiting Qi and strengthening heart.” Icariside II (ICS II) one main active components possessing cardiovascular protective anti-inflammatory properties. However, potential mechanisms ICS on myocardial ischemia (MI) remain unclear. Objective The aim study was to investigate preliminary molecular treating...
Abstract Background and Purpose Doxorubicin (DOX), an anthracycline chemotherapeutic agent, whose use is limited owing to its dose‐dependent cardiotoxicity. Mitochondrial oxidative stress plays a crucial role in the pathogenesis of DOX‐induced cardiotoxicity (DIC). Trilobatin (TLB), naturally occurring food additive, exhibits strong antioxidant properties, but cardioprotective effects DIC unclear. This study investigates effect TLB on DIC. Experimental Approach DOX was used generate vivo...
The G-protein-coupled receptor (GPR158), an orphan receptor, is highly expressed in the medial prefrontal cortex (mPFC) and identified as a novel therapeutic target for depression. Trilobatin naturally occurring food additive with potent neuroprotective properties. However, its pharmacological effects molecular mechanisms against depression remain unknown. Therefore, we explored whether trilobatin alleviates by targeting GPR158. Our results indicated that alleviated chronic unpredictable...
The anamorphic taxon Anacacumisporium appendiculatum gen. et sp. nov. is described and illustrated from fallen branches of decaying wood in Hainan, China. characterized by pigmented, transversely septate, appendaged conidia conidiophores that are brown, macronematous, mononematous bear one (or more ) integrated phialide at the tip. Complete sequences internal transcribed spacer (ITS) partial nuc 28S rDNA (28S) genes provided. new fungus compared with morphologically similar genera...
AIM:To determine whether HBV with the same characteristics causes dissimilar mutations in different hosts.METHODS: Full-length genome was amplified and linked pMD T18 vector.Positive clones were selected by double-restriction endonuclease digestion (Eco RⅠ Hin dⅢ) PCR.Twenty seven randomly from an asymptomatic mother [at two time points: 602 (1 d) 6022 (6 mo)] her son [602 (S)], phylogenetic mutational analysis performed using BioEditor, Clustal X MEGA software.Potential immune epitopes...
Hepatitis B virus (HBV) infection is highly prevalent in China. To identify the genotypes of HBV southern Yunnan Province China, full-length genomes were extracted from 1 Dai and 4 Hani carriers linked with pMD T-18 vector. For each patient, 3-10 clones sequenced directly a consensus sequence was created. Genotypic serotypic analysis revealed HBV/B (2 B2 adw2 2 new subgenotypes ayw1) HBV/C (C1 adrq+) genotypes. The divergences entire genome sequences subgenotype 0-0.9% 2.99-6.48% between...
Bardet-Biedl Syndrome (BBS) is a genetically heterogeneous autosomal recessive disorder with wide spectrum of clinical features. To date, mutations in 21 different genes (BBS1-21) have been identified as causing isolated or complex BBS phenotypes. In this report, we present three Chinese Miao ethnic patients who were diagnosed on the basis characteristic features and investigated exsome these patients.To evaluate disease genes, Agilent SureSelect system Illumina HiSeq 2000 platform for whole...
Sympodiosynnema gen. nov. is illustrated and described from dead stems of an unidentified plant in Hainan, southern China. The genus characterized by solitary dry naviculiform conidia, sympodially proliferating conidiogenous cells, synnematous conidiophores.
Atrosynnema digitosporum gen. & sp. nov., collected on dead branches in Hainan Province, China, is described and illustrated. It has black synnematous conidiomata, integrated unbranched conidiophores, monoblastic conidiogenous cells that produce brown, obclavate, dictyoseptate, rostrate conidia often with a mucilaginous cap around the apex.
A new species, Helicoma jianfenglingense, is described and illustrated from specimens collected on dead branches in Hainan Province. It differs conidial morphology the other known species. Descriptions illustrations are provided of two asexual fungi, Endophragmiella albiziae Cubasina albofusca , which recorded for first time China.
To assess the association of interferon gamma gene (IFNγ ) tag single nucleotide polymorphisms (Tag SNPs) with hepatitis B virus (HBV) infection in ethnic Dai and Hani minorities from Xishuangbanna, Yunnan.Peripheral blood samples were collected 300 minorities, each included 100 healthy controls 200 HBV infected individuals (including spontaneous recovery subjects chronic patients). Matrix-Assisted Laser Desorption/Ionization Time Flight Mass Spectrometry (MALDITOF-MS) was used to determine...
We aimed to determine the changes in frequency of respiratory pathogens and severe acute syndrome coronavirus 2 (SARS-CoV-2) during containment 2019 disease pandemic elucidate epidemiological interference that may have occurred after lifting measures.