A5100357648- Plant-based Medicinal Research
- Andrographolide Research and Applications
- Inflammasome and immune disorders
- Immune cells in cancer
- Sphingolipid Metabolism and Signaling
- Genomics, phytochemicals, and oxidative stress
- Bioactive Natural Diterpenoids Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Endometrial and Cervical Cancer Treatments
- Insect Utilization and Effects
- Liver Disease and Transplantation
- Ion Channels and Receptors
- Traumatic Brain Injury and Neurovascular Disturbances
- Berberine and alkaloids research
- Plant Stress Responses and Tolerance
- Traditional Chinese Medicine Analysis
- Phagocytosis and Immune Regulation
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Tryptophan and brain disorders
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
Zunyi Medical University
2022-2025
Shenyang Pharmaceutical University
2025
Minzu University of China
2025
First Affiliated Hospital of Gannan Medical University
2024-2025
Gannan Medical University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Sun Yat-sen University
2023-2024
Key Laboratory of Guangdong Province
2023
Changzhou No.2 People's Hospital
2022
Nanjing Medical University
2022
Cerebral ischemia/reperfusion causes exacerbated neuronal damage involving excessive neuroinflammation and oxidative stress. ROS is considered a signal molecule to activate NLRP3; thus, the ROS/NLRP3/pyroptosis axis plays vital role in pathogenesis of cerebral injury (CIRI). Therefore, targeting inhibition may be promising therapeutic tactic for CIRI.
To investigate the phenotypic heterogeneity of tissue-resident synovial fibroblasts and their role in inflammatory response rheumatoid arthritis (RA). We used single-cell spatial transcriptomics to profile cells gene expressions tissues identify changes patients with osteoarthritis, RA sustained remission active state. Immunohistology, multiplex immunofluorescence flow cytometry were subsets. Deconvolution methods further validated our findings two cohorts (PEAC R4RA) treatment response....
Introduction: Myocardial infarction (MI), the most prevalent ischemic heart disease, constitutes a primary cause of global cardiovascular disease with incidence and mortality. The pathogenesis MI is exceedingly intricate, PANoptosis playing pivotal role in its pathological process. Xian Ling Gu Bao capsule (XLGB) contains various active components, including flavonoids, terpenes, phenylpropanoids, exhibits wide range pharmacological activities. However, it remains unclear whether XLGB can...
Abstract Current treatments for ulcerative colitis (UC) remain limited, highlighting the need novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti‐inflammatory properties. In this study, dextran sulfate sodium (DSS)‐induced animal model is used to investigate effects of TLB on UC. It found significantly alleviates DSS‐induced UC in mice, as evidenced by reduction disease activity index, an increase colon length, improvement...
Oxidative stress and damage to macromolecules due free radicals such as reactive oxygen species (ROS) are commonly considered factors that can impair health. This study investigated the potential antioxidant properties of two subunit proteins associated with pigment-protein complex phycocyanin derived from Nostoc sphaeroides (Gexianmi). Bacterial expression vectors were separately constructed induce engineering proteins, Ns-α Ns-β. These then examined for their enhance antioxidative capacity...
Neural stem cells (NSCs) transplantation has been considered as a potential strategy to reconnect the neural circuit after spinal cord injury (SCI) but therapeutic effect was still unsatisfied because of poor inflammatory micro-environment SCI. Previous study reported that neuroprotection and immunomodulation were be most important mechanism NSCs transplantation. In addition, Wnt4 neurogenesis anti-inflammatory so it would an essential assistant agent for Our single sequence indicates...
Background Monocyte/macrophage (Mo/Mp) is a critical cell population involved in immune modulation of rheumatoid synovitis (RA) across different pathotypes. This study aims to investigate the contribution Mo/Mp clusters RA activity, and biological function particular subtypes remission. Methods We integrated single-cell RNA sequencing datasets from 4 published 1 in-house studies using Liger selected by comparison. estimated abundance bulk RNA-seq data 81 patients Pathobiology Early Arthritis...
To construction the telmisartan/collagen/polycaprolactone (PCL) nerve conduit and assess its effect on repairing sciatic defect in rats.The 60% collagen/hexafluoroisopropanol (HFIP) solution 40% PCL/HFIP were prepared mixed (collagen/PCL solution). Then 0, 5, 10, 20 mg of telmisartan with 10 mL collagen/PCL solution, respectively. Telmisartan/collagen/PCL conduits fabricated via high voltage electrospinning technology. The structure before after crosslinking was observed by using scanning...
Objective: To analyze the application of deep inspiration breath hold technique in radiotherapy after breast-conserving surgery for left breast cancer and improvement cardiac dose. Methods: A total 45 patients with treated our hospital were selected, selection time was set from January 2020 to August 2022. All received radiotherapy. The right breast, heart, lung volumes, dose parameters lungs, anterior descending coronary artery compared under free breathing (FB) (DIBH) technical modes....
Background: The adenomatous polyposis coli (APC) has been reported as a key tumor suppressor gene in hepatocellular carcinoma (HCC). However, the clinical significance of APC promoter methylation HCC remains unclear. This meta-analysis was conducted to assess relationship between and clinicopathological characteristics patients with HCC.Methods: Eligible publications were identified by online electronic databases (PubMed, Embase, EBSCO Cochrane Library). combined odds ratios (ORs) their...
Abstract Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents Strychnos nux-vomica L., which exerts multiple pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic effect. However, its potential effects limited clinical application, especially central nervous system toxicity. The present study was designed to investigate neurotoxicity mechanism brucine. Our results showed that brucine significantly induced Neuro-2a cells primary...
Abstract Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents Strychnos nux-vomica L., which exerts multiple pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic effect. However, its potential effects limited clinical application, especially central nervous system toxicity. The present study was designed to investigate neurotoxicity mechanism brucine. Our results showed that brucine significantly induced Neuro-2a cells primary...