A5102736024- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Herpesvirus Infections and Treatments
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Melanoma and MAPK Pathways
Guiyang Medical University
2017-2025
Affiliated Hospital of Guizhou Medical University
2017-2025
Zunyi Medical University
2019-2025
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Soochow University
2022-2023
First People’s Hospital of Zunyi
2022-2023
Guizhou Provincial People's Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
Guizhou Cancer Hospital
2017-2018
Abstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies revealed ncRNA-derived micropeptides exhibit regulatory functions in the development many tumours. Although some these inhibit tumour growth, others promote it. Understanding role ncRNA-encoded cancer poses new challenges for research, but also...
Tumor infiltrating lymphocyte therapy (TIL therapy) is one of the effective treatments for solid tumors. However, certain periods or sites tumors are not amenable to surgical resection. Meanwhile, abundant and dense extracellular matrix (ECM) regulatory cells (e.g., T (Tregs), myeloid-derived suppressor (MDSC)) in when infused back into treatment will prevent cell infiltration proliferation, thus inhibiting efficacy this approach. In study, a novel preparation was successfully developed by...
The exploration of the next-generation small diameter vascular grafts (SDVGs) will never stop until they possess high biocompatibility and patency comparable to autologous native blood vessels. Integrating biocompatible electrospinning (ES) matrices with highly bioactive stem cells (SCs) provides a rational promising solution. ES is simple, fast, flexible universal technology prepare extracellular matrix-like fibrous scaffolds in large scale, while SCs are valuable, multifunctional favorable...
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson's disease (PD). However, CNS delivery GDNF clinical trials has proven challenging due to blood-brain barrier (BBB) impermeability, poor diffusion within brain tissue, large size. We report that using non-toxic mobilization-enabled preconditioning, hematopoietic stem cell (HSC) transplantation-based macrophage-mediated gene may provide solution overcome these...
Erythroleukemia is a malignant disease in the blood system. Quinones consists of class antitumor agents. Calothrixin B carbazole-1,4-quinone alkaloid isolated from Calothrix cyanobacteria with unique indolo[3,2-j] phenanthridine framework. This study aimed to investigate anti-leukemic effect new derivative, L20, and dig up underlying mechanisms. Cytotoxicity analysis L20 has revealed that it shows significant IC50 concentrations HEL cells at low doses (1.10 ± 0.05 µM) than K562, KG-1a (5.46...
Endogenous circular RNAs (circRNAs) and microRNAs (miRNAs) have been shown to regulate the pathogenesis of acute myeloid leukemia (AML). The current study aimed identify role circRNA 0040823 (circ_0040823) in AML. Microarray datasets were analyzed differentially expressed circRNAs AML patients. Peripheral blood samples obtained from healthy volunteers patients for measurement circ_0040823 miR-516b levels. overexpression or knockdown a target gene cells was achieved by transfection with...
Abstract Background Acute lung injury (ALI) is a serious disease with highly morbidity and mortality that causes health problems worldwide. Atypical mitogen activated protein kinases (MAPKs) play critical roles in the development of tissues have been proposed as promising therapeutic targets for various diseases. However, potential role atypical MAPKs ALI remains elusive. In this study, we investigated family member MAPK4 using LPS-induced murine model. Results We found deficiency mice...
Acute myeloid leukemia (AML) is one of the most common hematological malignancies and accounts for about 20% childhood leukemias. Currently, immunotherapy recommended treatment schemes recurrent AML patients to improve their survival rates. Nonetheless, low remission high mortality rates are observed in challenge prognosis patients. To address this problem, we aimed establish verify a reliable prognostic risk model using immune-related genes evaluation recommendation personalized...
The outbreak of coronavirus disease 2019 (COVID‑19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has spread worldwide and become a public health emergency, principally due to the inflammatory response cytokine storm, as well deficiency specific vaccines antiviral drugs. Despite fact that mesenchymal stem cells (MSCs) are acknowledged possess unique immunomodulatory capabilities have promising prospects in regenerative medicine, efficacy use MSCs on...