A5100408390- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Molecular Biology Techniques and Applications
- Prostate Cancer Treatment and Research
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Prenatal Screening and Diagnostics
- Immune cells in cancer
- interferon and immune responses
- FOXO transcription factor regulation
Peking University Shenzhen Hospital
2022-2025
First Affiliated Hospital Zhejiang University
2013-2025
University of South China
2025
University of Hong Kong - Shenzhen Hospital
2022-2024
Zunyi Medical University
2014-2024
Hong Kong University of Science and Technology
2022-2024
Stony Brook School
2024
Stony Brook University
2024
Nanjing Medical University
2017-2024
Union Hospital
2010-2024
Initiation, growth, recurrence, and metastasis of head neck squamous cell carcinomas (HNSCC) have been related to the behavior cancer stem cells (CSC) that can be identified by their aldehyde-dehydrogenase-isoform-1 (ALDH1) activity. We quantified enriched ALDH1+ within HNSCC lines subsequently characterized phenotypical functional properties like invasion capacity epithelial-mesenchymal transition (EMT). Spheroid culture CSC from five up 5-fold. In spheroid-derived (SDC) parental...
Inflammation is a common medical complication in colorectal cancer (CRC) patients, which plays significant roles tumor progression and immunosuppression. However, the influence of inflammatory conditions on response to immune checkpoint inhibitors (ICI) incompletely understood. Here we show that patient with high microsatellite instability (MSI-H) CRC local condition, primary progresses but its liver metastasis regresses upon Pembrolizumab treatment. In silico investigation prompted by this...
Neoantigens are ideal targets for dendritic cell (DC) vaccines. So far, only a few neoantigen-based DC vaccines have been investigated in clinical trials. Here, we reported case of patient with metastatic gastric cancer who received personalized neoantigen-loaded monocyte-derived (Neo-MoDC) followed by combination therapy the Neo-MoDC and immune checkpoint inhibitor (ICI). The developed T responses against neoantigens after receiving vaccine alone. following triggered stronger response...
Abstract Background Cancer‐associated fibroblasts (CAFs) are potential targets for cancer therapy. Due to the heterogeneity of CAFs, influence CAF subpopulations on progression lung is still unclear, which impedes translational advances in targeting CAFs. Methods We performed single‐cell RNA sequencing (scRNA‐seq) tumour, paired tumour‐adjacent, and normal samples from 16 non‐small cell (NSCLC) patients. were analyzed after integration with published NSCLC scRNA‐seq data. SpaTial enhanced...
Summary Despite the importance of host–microbe interactions in natural ecosystems, agriculture and medicine, impact long‐term (especially decades or longer) microbial colonization on dynamics host genomes is not well understood. The vegetable crop ‘Jiaobai’ with enlarged edible stems was domesticated from wild Zizania latifolia (Oryzeae) approximately 2000 years ago as a result persistent infection by fungal endophyte, Ustilago esculenta . Asexual propagation via infected rhizomes only means...
Background Glioma remains a diagnostic challenge because of its variable clinical presentation and lack reliable screening tools. Long noncoding RNAs (lncRNAs) regulate gene function in wide range pathophysiological processes are therefore emerging biomarkers for prostate cancer, hepatic other tumor diseases. However, the effective use lncRNAs as diagnosis glioma unproven. Methods This study included 42 patients 10 healthy controls. lncRNA mRNA microarray chips were used to identify...
Since there are few studies exploring genes associated with lymphatic metastasis of thyroid carcinoma (THCA), this study was conducted to explore THCA and investigate the relationship immune infiltration.Differentially expressed were analyzed based on The Cancer Genome Atlas Program (TCGA) database; a protein-protein interaction(PPI)network constructed screen for pivotal genes. Based identified hub genes, their expression in without determined. Functional enrichment analysis performed....
Abstract Background Accurate predictors of survival for patients with advanced gastric cancer treated neoadjuvant chemotherapy are currently lacking. In this study, we aimed to evaluate the prognostic significance neutrophil-lymphocyte ratio (NLR) in stage III-IV who received chemotherapy. Methods We enrolled 46 study. The NLR was divided into two groups: high (>2.5) and low (≤2.5). Univariate analysis on progression-free (PFS) overall survival(OS) performed using Kaplan-Meier log-rank...
Background: The leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5) is considered a cancer stem cell marker, and often overexpressed in tumors. interaction between Lgr5 the immune-related tumor microenvironment not completely understood. aim of this study was to examine role gastric (GC), explore possible immunological mechanisms influencing expression that are governed by regulatory T cells. Methods: examined 180 GC tumors immunohistochemistry, 80 pairs for analysis Th1/Th2...
Ferrets have become an indispensable tool in the understanding of influenza virus virulence and pathogenesis. Furthermore, ferrets are preferred preclinical model for vaccine therapeutic testing. Here we characterized infectome during different stages infectious process with without prior specific immunity to influenza. RNA from lung tissue lymph nodes infected naïve animals was subjected next-generation sequencing, followed by de novo data assembly annotation resulting sequences; this...
Targeted expression of gene technique is an important therapeutic strategy for lung cancer. MicroRNA-7 has been well documented as a promising tumor suppressor but never test in specific gene-promoter-targeted cancer therapy. Here, we first evaluated the efficacy miR-7 operated by promoter TTF-1, lineage-specific oncogene cancer, vitro using eukaryotic vector TTF-1-promoter-operated (termed p-T-miR-7). Interestingly, nude mice model, growth and metastasis human cells vivo were significantly...