A5039925585- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Retinal Development and Disorders
- Immune cells in cancer
Sun Yat-sen University
2020-2024
Sun Yat-sen University Cancer Center
2020-2024
State Key Laboratory of Oncology in South China
2020-2024
Colorectal Surgical Associates
2022
Huazhong University of Science and Technology
2018-2021
Tongji Hospital
2018-2021
Clinical and experimental evidence has shown that tumor-associated macrophages promote cancer initiation progression. However, the macrophage-derived molecular determinants regulate colorectal metastasis have not been fully characterized. Here, we demonstrate M2 macrophage-regulated cells' migration invasion is dependent upon exosomes (MDE). MDE displayed a high expression level of miR-21-5p miR-155-5p, MDE-mediated depended on these two miRNAs. Mechanistically, miR-155-5p were transferred...
Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia tumors response to it determining efficacy antiangiogenic therapy while connection between them remains unclear. Here, we found that lactate accumulated tumor environment CRC acted as substrates histone lactylation, this process was further induced by cellular enhanced glycolysis hypoxia. We determined patients resistant bevacizumab presented with...
Inflammation is a common medical complication in colorectal cancer (CRC) patients, which plays significant roles tumor progression and immunosuppression. However, the influence of inflammatory conditions on response to immune checkpoint inhibitors (ICI) incompletely understood. Here we show that patient with high microsatellite instability (MSI-H) CRC local condition, primary progresses but its liver metastasis regresses upon Pembrolizumab treatment. In silico investigation prompted by this...
Cellular senescence is a state of irreversible cell growth arrest and cells permanently lose proliferation potential. Induction cellular might be novel therapy for cancer cells. TRIB2 has been reported to participate in regulating drug resistance various However, the role colorectal (CRC) its molecular mechanism remains unclear. The expression tissues adjacent was detected by immunohistochemistry RT-PCR. growth, cycle distribution were evaluated Cell Counting Kit-8 (CCK8) assay, flow...
Abstract BECN1 is a critical regulator of autophagy, which plays important roles in tumor formation and metastasis. However, the autophagy-independent role clinical prediction value still need to be explored. Here, we observed significantly lower expression colorectal cancers (CRCs) compared with adjacent normal colon tissue, downregulation was positively related poor prognosis CRC patients. In addition, found that knockdown markedly promoted cell motility invasion. Bioinformatics gene set...
Abstract Resistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Here, we identified TRIM25 as an epigenetic regulator oxaliplatin (OXA) resistance CRC. The level OXA-resistant who experienced recurrence during follow-up period was significantly higher than those had no recurrence. Patients high expression a rate and worse disease-free survival low expression. Downregulation dramatically inhibited, while overexpression increased, CRC...
β2-microglobulin (B2M) and Janus kinases 1 2 (JAK1/2) mutations have been suggested as genetic mechanisms of immune evasion for anti-programmed cell death protein (PD-1) therapy. Whether B2M JAK1/2 lose-of-function mutation can cause primary resistance to anti-PD-1 therapy in colorectal carcinoma (CRC) patients remains controversial. Here, we sought compare the efficacy DNA mismatch repair deficient/microsatellite instability-high CRC with or without mutations. Thirty-Five who received were...
Angiogenesis plays important roles in solid tumors progression. Growth factors such as vascular endothelial growth (VEGFs) can induce angiogenesis and hypoxia promotes the expression of VEGFs through activating hypoxia-inducible factor 1 (HIF-1α). However, regulation HIF-1α still not been fully understood. Here, we demonstrate that Sine Oculis Homeobox Homolog 4 (SIX4) is up-regulated colorectal cancer (CRC) high SIX4 predicts a poor prognosis. Overexpression enhances tumor vitro vivo, while...
Phosphoinositide-3-kinase regulatory subunit 3(PIK3R3) is overexpressed in different types of human cancer. We previously reported the important role PIK3R3 colorectal cancer (CRC). However, prognosis effect CRC still remaining unclear. In this study, we explored online clinical databases to analyze differences between higher and lower expression patients. Interestingly, found that better disease-free survival (DFS) were occurred patients with PIK3R3, but there no significant difference...
The log odds of positive lymph nodes (LODDS) was considered a superior staging system to N stage in colon cancer, yet its value determining the optimal duration adjuvant chemotherapy for III cancer patients has not been evaluated. This study aims assess prognostic model that combines LODDS with clinicopathological information and stratify these using model, identifying individuals who could benefit from varying durations chemotherapy. A total 663 consecutive diagnosed underwent tumor...
Abstract Background For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim this study was to evaluate prognostic value factors and effect oxaliplatin-based among dMMR stageIIcolon cancers. Methods Patients with stage II cancers diagnosed between June 2011 May 2018 were enrolled in study. Clinicopathological characteristics, treatment, follow-up data retrospectively collected. group defined as having one...
Abstract Background The number of colorectal cancer liver metastases (CRLMs) is usually considered a contradictory indicator to surgical resection. However, some patients with initially unresectable CRLMs can receive radical local treatment after conversion therapy. This study aimed evaluate the effect therapy and prognosis more than 10 CRLMs. Methods Data for total 229 were retrospectively reviewed between December 2012 January 2020. Among these patients, 107 had ≥10 CRLMs, 122 <10...
Abstract This study investigates advanced colorectal cancer (CRC), focusing on its tendency for distant metastasis and chemotherapy resistance. It highlights the importance of PANoptosis, a cell death pathway, role Receptor-interacting serine/threonine-protein kinase (RIPK) family in tumor progression. RIPK4’s tissue-specific functions behavior are emphasized, including influence invasion, migration, oxidative stress The reveals critical balance reactive oxygen species (ROS) cells, linked to...
TPS3637 Background: Approximately 12% of stage III colon cancer are deficient mismatch repair (dMMR), leading to high levels microsatellite instability (MSI-H). In the KEYNOTE-177 study, anti–PD-1 inhibitor Pembrolizumab alone significantly improved progression free survival (PFS) versus chemotherapy as first-line therapy for metastatic colorectal (mCRC) patients with MSI-H/dMMR. We conducting a phase randomised trial determine whether anti-PD-1 Sintilimab monotherapy can improve disease...
Abstract Background Resistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). TRIM25, an E3-ubiquitin ligase, has been reported play a vital role tumorigenesis. This project aims explore function and mechanism TRIM25 regulating oxaliplatin resistance cancer. Methods The expression tissues were examined by publicly available dataset, Immunohistochemistry western blot. Further survival analysis was conducted using Kaplan-Meier method....
Objective: To assess the oncologic outcomes of radical nephroureterectomy (RUN) combined with adjuvant chemotherapy (ACT) in patients high risk upper tract urothelial carcinoma (UTUC). Methods: One-hundred-thirty-four individuals high-risk UTUC who underwent RUN or without ACT were evaluated. Cox proportional hazard model and Kaplan-Meier analysis used to determine overall cancer specific survival cohort. Results: The median follow-up duration was 24 months (range: 6-36) group (n=61) 18...
Objective: To investigate the factors affecting success of conversion therapy in patients with initially unresectable colorectal cancer liver metastases (CRLM) order to provide evidence-based medical evidence for formulating individualized treatment strategies patients. Methods: A retrospective case-control study was used this study. Clinical data 232 CRLM receiving first-line systemic Sun Yat-sen University Cancer Center from January 2013 2020 were collected, including 98 successful and 134...
Abstract Background Resistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Tripartite motif containing 25 (TRIM25), an E3-ubiquitin ligase, has been reported play a vital role tumorigenesis. The present study aimed explore function and mechanism TRIM25 regulating oxaliplatin resistance cancer. Methods expression tissues was examined using publicly available datasets, immunohistochemistry, western blotting. Further survival analysis...