A5100345898- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Endoplasmic Reticulum Stress and Disease
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cellular Mechanics and Interactions
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
Guangxi Medical University
2015-2025
First Affiliated Hospital of GuangXi Medical University
2015-2025
Jilin University
2024-2025
Hunan University of Traditional Chinese Medicine
2021-2025
Nanyang Medical College
2025
Fudan University
2014-2024
Wuhan Children's Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Hunan University of Technology
2024
Ningbo University
2024
Agonist-induced phosphorylation of G-protein-coupled receptors has been shown to facilitate the desensitization processes, such as receptor internalization, decreased efficiency coupling G-proteins, or ligand affinity. The lowered affinity may be an intrinsic property phosphorylated it result altered interactions between modified and downstream components G-proteins arrestins. To address this issue, we purified cAR1, major chemoattractant Dictyostelium discoideum by a strategy that is...
The SPOP E3 ubiquitin ligase gene is frequently mutated in human prostate cancers. Here, we demonstrate that recognizes a Ser/Thr-rich degron the hinge domain of androgen receptor (AR) and induces degradation full-length AR inhibition AR-mediated transcription cancer cell growth. splicing variants, most which lack domain, escape SPOP-mediated degradation. Prostate-cancer-associated mutants cannot bind to promote destruction. Furthermore, androgens antagonize AR, whereas antiandrogens this...
Iron excess is closely associated with tumorigenesis in multiple types of human cancers, underlying mechanisms yet unclear. Recently, iron deprivation has emerged as a major strategy for chemotherapy, but it exerts tumor suppression only on select malignancies. Here, we report that the suppressor protein p53 downregulated during excess. Strikingly, polyporphyrin heme binds to protein, interferes p53-DNA interactions, and triggers both nuclear export cytosolic degradation p53. Moreover,...
Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia tumors response to it determining efficacy antiangiogenic therapy while connection between them remains unclear. Here, we found that lactate accumulated tumor environment CRC acted as substrates histone lactylation, this process was further induced by cellular enhanced glycolysis hypoxia. We determined patients resistant bevacizumab presented with...
Gradients of chemoattractants elicit signaling events at the leading edge a cell even though chemoattractant receptors are uniformly distributed on surface. In highly polarized Dictyostelium discoideum amoebas, membrane-associated betagamma subunits heterotrimeric guanine nucleotide-binding proteins (G proteins) were localized in shallow anterior-posterior gradient. A applied generated binding sites for pleckstrin homology (PH) domains inner surface membrane pattern similar to that...
The molecular machinery required for autophagy is highly conserved in all eukaryotes as seen by the high degree of conservation proteins involved formation autophagosome membranes. Recently, both yeast Apg8p and its rat homologue Map1lc3 were identified essential constituents membrane a processed form. In addition, human exist two modified forms produced series post-translational modifications including critical C-terminal cleavage after Gly residue, smaller form associated with Herein, we...
The purpose of this study was to investigate invasion- and metastasis-related genes in gastric cancer. To end, we used the transwell system select a highly invasive subcell line from minimally parent cells compared gene expression paired cell lines with high- low-invasive potentials. Lysyl oxidase-like 2 (LOXL2) overexpressed line. Immunohistochemical analysis revealed that LOXL2 markedly increased carcinoma relative normal epithelia, overexpression primary tumor significantly associated...
The molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the cell cycle regulation during emergence. In this study, we conducted comprehensive evolutionary analysis CDK cyclin proteins metazoans their unicellular relatives. Our divided family into eight subfamilies. Seven subfamilies (CDK1/2/3, CDK5, CDK7, 20, CDK8/19, CDK9, CDK10/11) are conserved fungi, with remaining subfamily, CDK4/6, found only eumetazoans....
In chemotactic cells, G protein–coupled receptors activate Ras proteins, but it is unclear how Ras-associated pathways link extracellular signaling to cell migration. We show that, in Dictyostelium discoideum, activated forms of RasC prolong the time course TORC2 (target rapamycin [Tor] complex 2)-mediated activation a myristoylated protein kinase B (PKB; PKBR1) and phosphorylation PKB substrates, independently phosphatidylinositol-(3,4,5)-trisphosphate. Paralleling these changes, kinetics...
Cellular protrusions are typically considered as distinct structures associated with specific regulators. However, we found that these regulators coordinately localize propagating cortical waves, suggesting a common underlying mechanism. These molecular events fell into two excitable networks, the signal transduction network STEN and cytoskeletal CEN different wave substructures. Computational studies using coupled-network model reproduced features showed morphology kinetics of waves...
Abstract Recent studies have demonstrated that gastric cancer stem cells (CSCs) are a rare sub-group of (GC) and an important role in promoting the tumor growth progression GC. In present study, we glycolytic enzyme Enolase 1 (ENO1) was involved regulation cell-like characteristics GC cells, as compared to parental cell lines PAMC-82 SNU16, expression ENO1 spheroids markedly increased. We then observed could enhance characteristics, including self-renewal capacity, invasion migration,...
Bispecific T cell engagers (BiTEs) are bispecific antibodies that redirect cells to target antigen-expressing tumors. We hypothesized BiTE-secreting could be a valuable therapy in solid tumors, with distinct properties mono- or multi-valent strategies incorporating chimeric antigen receptor (CAR) cells. Glioblastomas represent good model for tumor heterogeneity, representing significant therapeutic challenge. detected expression of tumor-associated epidermal growth factor (EGFR), EGFR...
Despite the Yangtze River Basin (YRB)’s abundant land and forestry resources, there is still a dearth of research on forecasting habitat quality changes resulting from various geographic environmental factors that drive landscape transformations. Hence, this study concentrates YRB as focal area, with aim utilizing Patch Landscape Upscaling Simulation model (PLUS) to scrutinize spatial distribution patterns evolution HQ under four scenarios: natural development scenario (NDS), farmland...
Much recent attention has been focused on Aurora C, the third member of mammalian kinases family that plays significant roles in mitosis. We report here using sensitive RT‐PCR to amplify C‐terminal, we found C is not only expressed highly testis, but also among 16 other human tissues a broad‐spectrum way. as chromosomal passenger protein, co‐localized with B and Survivin mitotic cells. can be associated vivo directly binds vitro . Over‐expression catalytically inactive mutant impaired...
Septins, a conserved family of cytoskeletal GTP‐binding proteins, were presented in diverse eukaryotes. Here, comprehensive phylogenetic and evolutionary analysis for septin proteins metazoan was carried out. First, we demonstrated that all could be clustered into four subgroups, the representative homologue every subgroup non‐vertebrate chordate Ciona intestinalis , indicating emergence subgroups should have occurred prior to divergence vertebrates invertebrates, expansion gene number...
The Prolyl hydroxylase 1 (EGLN2) is known to affect tumorigenesis by regulating the degradation of hypoxia-inducible factor. Polymorphisms in EGLN2 may facilitate cancer cell survival under hypoxic conditions and directly associate with susceptibility. Here, we examined contribution a 4-bp insertion/deletion polymorphism (rs10680577) within distal promoter risk hepatocelluar carcinoma (HCC) Chinese populations. rs10680577 HCC was investigated 623 cases 1,242 controls replicated an...
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B pathogenic mutations. The symptoms WD can be effectively prevented if the affected individuals are identified and intervened early. However, clinical utility this molecular analysis challenging due to hundreds variants with various effects in gene. Here, we aim describe spectrum assess their Han Chinese population.The gene was directly sequenced 632 unrelated patients 503 healthy individuals. were...