A5064146611- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Environmental Toxicology and Ecotoxicology
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Cardiac Arrest and Resuscitation
- Mechanisms of cancer metastasis
- Cardiac, Anesthesia and Surgical Outcomes
- Mercury impact and mitigation studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture Nutrition and Growth
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Renal and related cancers
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Marine Biology and Environmental Chemistry
- Immune Cell Function and Interaction
Guangdong Academy of Medical Sciences
2010-2025
Guangdong Provincial People's Hospital
2008-2025
Fudan University
2016-2025
Zhangzhou Municipal Hospital of Fujian Province
2019-2025
Shandong University
2021-2025
Fujian Medical University
2019-2025
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
State Key Laboratory of Genetic Engineering
2012-2024
Southern Medical University
2022-2024
Soochow University
2024
Abstract Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss function. POI heterogeneous condition, and its molecular etiology unclear. To identify genetic variants associated with POI, here we performed whole-exome sequencing in cohort 1,030 patients POI. We detected 195 pathogenic/likely pathogenic 59 known POI-causative genes, accounting for 193 (18.7%) cases. Association analyses comparing the control 5,000 individuals without identified 20...
Cytosolic delivery of small interfering RNA (siRNA) remains challenging, and a profound understanding the cellular uptake intracellular processing siRNA systems could greatly improve development siRNA-based therapeutics. Here, we show that caveolae-mediated endocytosis (CvME) accounts for robust mannose-modified trimethyl chitosan-cysteine/tripolyphosphate nanoparticles (MTC/TPP NPs) to macrophages by circumventing lysosomes. We Golgi complex ER are key organelles required efficient in which...
Xylooligosaccharides ameliorate insulin resistance by increasing Akk. muciniphila and intestinal barrier function in gestational diabetes mellitus (GDM) mice.
Much recent attention has been focused on Aurora C, the third member of mammalian kinases family that plays significant roles in mitosis. We report here using sensitive RT‐PCR to amplify C‐terminal, we found C is not only expressed highly testis, but also among 16 other human tissues a broad‐spectrum way. as chromosomal passenger protein, co‐localized with B and Survivin mitotic cells. can be associated vivo directly binds vitro . Over‐expression catalytically inactive mutant impaired...
Recent studies have revealed that alternatively activated macrophages (AAMs) are involved in tumor progression. However, the effect of AAMs on metastasis prostate cancer is poorly understood. In present study, tissues 42 patients with adenocarcinoma (PCa) were used analysis associated (TAMs) and by immunofluorescence. The followed up for 5 years. associations TAMs clinicopathological features outcome these cases evaluated. Immunofluorescent indicated mean number (CD68-positive cells) PCa...
Determination of the cause malignant pleural effusions is important for treatment and management, especially in cases unknown primaries. There are limited biomarkers available prediction effusion clinical practice. Hence, we evaluated levels five tumor (CEA, AFP, CA125, CA153 CA199) predicting a retrospective study. Kruskal-Wallis or Mann-Whitney U tests were carried out to compare markers among different forms neoplasia - lung squamous cell carcinoma, adenocarcinoma, small mesothelioma,...
Abstract Premature ovarian insufficiency (POI) is a major cause of reduced female fertility and affects approximately 1% women under 40 years age. Recent advances emphasize the genetic heterogeneity POI. Fanconi anemia (FA) genes, traditionally known for their essential roles in DNA repair cytogenetic instability, have been demonstrated to be involved meiosis germ cell development. Here, we conducted whole-exome sequencing (WES) 50 Han Chinese patients with Rare missense variants were...
Renal tubular epithelial cell apoptosis is an important pathological mechanism of septic acute kidney injury (AKI). Endotoxin, also known as lipopolysaccharide (LPS), has a key role in AKI and can directly induce apoptosis. The upregulation receptor‑interacting protein kinase 3 (RIPK3) cells been reported AKI, with RIPK3 mediating several types. In the present study, effect on endotoxin‑induced was investigated mouse vitro vivo. It found that expression markedly increased AKI....
Abstract Purpose: This study evaluates the proapoptotic function of integrin β3 in human hepatocellular carcinoma (HCC). Experimental Design: The expression 67 HCC specimens paired with corresponding neighboring nontumorous tissue was studied by quantitative real-time PCR and Western blot. SMMC-7721 hepatoma cells overexpressing ITGB3 (gene coding β3) determined through colony formation, serum starvation, anoikis assay. Results: Compared pathologically normal liver tissue, ∼60% showed a...
Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and suppresses several steps required for metastasis. However, the role hepatocellular carcinoma (HCC) remains elusive. In this study, we found that level significantly down-regulated HCC tissues. Expression SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized to apoptosis induced by serum...