A5019386123- Genetic factors in colorectal cancer
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Nutritional Studies and Diet
- Autophagy in Disease and Therapy
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Mesenchymal stem cell research
- Systemic Sclerosis and Related Diseases
- Ocular Surface and Contact Lens
- Multiple Myeloma Research and Treatments
- Cancer-related Molecular Pathways
- Skin Protection and Aging
Tongji University
2015-2025
Sun Yat-sen University
2017-2025
Sun Yat-sen University Cancer Center
2017-2025
Tongji Hospital
2022-2025
Stomatology Hospital
2024
Hospital of Stomatology, Sun Yat-sen University
2024
State Key Laboratory of Oncology in South China
2017-2023
Shanghai Tenth People's Hospital
2018-2022
Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia tumors response to it determining efficacy antiangiogenic therapy while connection between them remains unclear. Here, we found that lactate accumulated tumor environment CRC acted as substrates histone lactylation, this process was further induced by cellular enhanced glycolysis hypoxia. We determined patients resistant bevacizumab presented with...
Diabetic retinopathy (DR) is one of the leading causes blindness in world, and timely prevention treatment are very important. Previously, we found that a neurodegenerative factor, Glia maturation factor-β (GMFB), was upregulated vitreous at early stage diabetes, which may play an important role pathogenesis. Here, high glucose environment, large amounts GMFB protein can be secreted vitreous, translocates ATPase ATP6V1A from lysosome, preventing its assembly alkalinizing lysosome retinal...
Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the response to programmed cell death protein (PD-1) blockade in colorectal cancers (CRCs) deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified.
Abstract Resistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Here, we identified TRIM25 as an epigenetic regulator oxaliplatin (OXA) resistance CRC. The level OXA-resistant who experienced recurrence during follow-up period was significantly higher than those had no recurrence. Patients high expression a rate and worse disease-free survival low expression. Downregulation dramatically inhibited, while overexpression increased, CRC...
Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential cell-based tools for treatment SSc.BMSCs were isolated from bone mice identified with surface markers according to multilineage differentiation. EVs BMSC culture medium by ultracentrifugation Nanosight NS300 particle size analyzer, transmission electron microscopy (TEM), western blot. The...
To study the biological functions and applications of human amniotic epithelial cell-derived extracellular vesicles (hAEC-EVs), cargos hAEC-EVs were analyzed using miRNA sequencing proteomics analysis. The hAECs in this had specific characteristics. Multi-omics analyses showed that matrix (ECM) reorganization, inhibition excessive myofibroblasts, promotion target cell adhesion to ECM their primary functions. We evaluated application for corneal alkali burn healing rabbits elucidated...
The DNA methylation of CYP24A1 can regulate its gene expression and may play a role in the occurrence progression colorectal cancer (CRC). However, association between prognosis CRC patients has not yet been reported. In this study, differential analysis was conducted both blood tissue cohorts, performed cohort with vitro validation. GO KEGG enrichment analyses were on CYP24A1-related genes. A correlation promoter explored. Kaplan-Meier survival Cox regression to investigate impact patients....
Purpose: The purpose of this study was to investigate the activated core kinases involved in DNA damage responses (DDR) during ferroptosis retinal pigment epithelial (RPE) cells vitro and their regulatory effects on ferroptosis. Methods: Ferroptosis induced by erastin RPE (iRPE) derived from human umbilical cord mesenchymal stem (hUCMSCs), hUCMSCs, pluripotent cell-derived (iPSC-RPE) cells. CCK8 employed measure cell viability. Calcein/PI staining used detect ferroptotic γ-H2AX, 8-oxoG,...
The oxidative balance score (OBS) measures stress from diet and lifestyle, but research linking it to colorectal cancer (CRC) risk is scarce varies in calculation methods. We conducted a case-control study Guangzhou, China, involving 2799 CRC cases an equal number of sex- age-matched controls. adopted compared four different methods for calculating the OBSs. odds ratio (OR) 95% confidence interval (95%CI) relationship between OBS were determined using unconditional logistic regression model....
<title>Abstract</title> The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is one the significant pathogenic mechanisms for formation subretinal fibrosis in age-related macular degeneration (AMD). Multiple signaling pathways that promote EMT have been well described, yet endogenous inhibit within RPE remain largely elusive. In this study, we confirmed expression CRX human and embryonic stem cell-derived (ESC-RPE) cells. By employing sub-culture to disrupt...
The prevalence of Lynch syndrome (LS) varies significantly in different populations, suggesting that ethnic features might play an important role. We enrolled 3330 consecutive Chinese patients who had surgical resection for newly diagnosed colorectal cancer. Universal screening LS was implemented, including immunohistochemistry mismatch repair (MMR) proteins, BRAFV600E mutation test and germline sequencing. Among the 3250 eligible patients, MMR protein deficiency (dMMR) detected 330 (10.2%)...
Systemic inflammation was recognized as an essential factor contributing to the development of malignancies. This study aimed investigate prognostic value pre-operative lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte (PLR) in patients with colorectal liver-only metastases (CLOM) undergoing hepatectomy. We retrospectively enrolled 150 consecutive CLOM between 2000 2012. The optimal cutoff values continuous LMR, NLR, PLR were determined using...
Purpose: This study aimed to explore the role of protein kinase A (PKA) pathway in proliferative vitreoretinopathy (PVR) and effect PKA inhibitor H89 on experimental PVR. Methods: Epiretinal membranes (ERMs) were acquired from PVR patients analyzed by frozen-section immunofluorescence. An vivo model was developed intravitreal injecting rat eyes with ARPE-19 cells platelet-rich plasma, changes eye structures vision function observed. vitro epithelial-mesenchymal transition (EMT) cell...
Voltage-gated sodium channel 1.5 (Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, prognostic significance Nav1.5 expression remains undetermined. The present study aimed to explore associations with clinical outcomes estrogen receptor-β (ER-β) in non-metastatic patients receiving radical resection.A total 269 consecutive pathologically confirmed stages I-III who underwent resection were selected. ER-β was detected by using...
Adipose-derived stem cells (ASCs) have shown a strong protective effect on retinal degenerative diseases (RDD) after being transplanted into the subretinal space in an animal model. Recently, several clinical trials been conducted to treat RDD with intravitreal transplantation of cells, including ASCs. However, outcomes were not satisfactory. To investigate if site alters outcome cell-based therapy for RDD, we isolated rat ASCs (rASCs) and labeled them green fluorescent protein. Autologous...
Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a key pathological event in proliferative diseases such as vitreoretinopathy (PVR). This study aimed to explore new method reverse EMT RPE develop an improved therapy for diseases.In vitro, human embryonic stem cell-derived were passaged and cultured at low density extended period time establish model. At different stages after treatment with known molecules or combinations molecules, the morphology was...
Plant-based diets are associated with a lower risk of colorectal cancer, but the might differ by quality plant-based diets. This study aimed to investigate association between different types dietary patterns and cancer in Chinese population. We conducted case-control 2799 eligible cases sex- age-matched controls Guangzhou, China. A validated food frequency questionnaire was used collect data, from which we derived diet indices, including index (PDI), healthy PDI (hPDI), unhealthy (uPDI)....
Background Systemic sclerosis (SSc) is a rare autoimmune disease characterized by extensive skin fibrosis. There are no effective treatments due to the severity, multiorgan presentation, and variable outcomes of disease. Here, integrated bioinformatics was employed discover tissue-specific expressed hub genes associated with SSc, determine potential competing endogenous RNAs (ceRNA) regulatory networks, identify targeted drugs. Methods In this study, four datasets SSc were acquired. To...
The association between circulating saturated fatty acids (SFAs) including very long-chain SFAs (VLCSFAs) and colorectal cancer (CRC) risk has not been clearly established. To investigate the serum CRC in Chinese population, 680 cases sex age-matched (5-year interval) controls were recruited our study. Serum levels of detected by gas chromatography. Unconditional logistic regression models used to estimate odds ratios (ORs) 95% confidence intervals (CIs) for risk. Results showed that total...
: Background: A comprehensive investigation into immune cell infiltration provides more accurate and reliable prognostic information for patients with colorectal liver oligometastases (CLO) after metastasectomy.Simultaneous detection of the constituents CD3+, CD8+, Foxp3+ T, α-SMA+ cells in oligometastasis 133 was conducted using a four-colour immunohistochemical multiplex technique. Immune were quantified, tumour-infiltrating lymphocyte (TIL) ratios subsequently calculated. Correlation...
The aim of this study was to assess the prognostic value CD8+ tumor infiltrating lymphocytes (TIL) combined with programmed cell death-ligand 1 (PD-L1) expression for patients solitary colorectal cancer liver metastasis (SCLM) undergoing R0 resection.Patients curative hepatectomy SCLM were reviewed. Immunohistochemical multiplex technique used quantifying TIL, and immunohistochemical staining assessing PD-L1 expression. immune microenvironment (TIME) classified as strong high TIL low PD-L1,...