A5068827839- Sulfur-Based Synthesis Techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Corneal Surgery and Treatments
- Radical Photochemical Reactions
- Extracellular vesicles in disease
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Surface and Contact Lens
- Systemic Sclerosis and Related Diseases
- Skin Protection and Aging
- Advanced Drug Delivery Systems
- Catalytic C–H Functionalization Methods
- Pancreatic and Hepatic Oncology Research
- Nanocluster Synthesis and Applications
- Metal complexes synthesis and properties
- Ferroptosis and cancer prognosis
- Graphene and Nanomaterials Applications
- Electromagnetic wave absorption materials
- Industrial Gas Emission Control
- Magnetic Properties and Synthesis of Ferrites
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
Tianjin University of Traditional Chinese Medicine
2020-2025
Shanghai University of Medicine and Health Sciences
2024-2025
Zhejiang Sci-Tech University
2022-2024
Tongji University
2021-2024
Tongji Hospital
2021-2024
Wenzhou Medical University
2015-2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Baoji City Central Hospital
2024
First Hospital of China Medical University
2023-2024
China Medical University
2024
UVB exposure is one of the primary factors responsible for development photoaging, and aim this study was to investigate mechanism involved in photoprotective properties resveratrol (RES) UVB-induced photoaging. Photoaging models Hacat cells ICR mice were established by irradiation. The effect RES on cell viability then assessed using MTT assay. reactive oxygen species (ROS) production detected through a fluorescent probe oxidized glutathione (GSSH) content, superoxide dismutase (SOD)...
Abstract In this study, we newly designed and synthesized a small library of ten structurally related C,N‐cyclometalated ruthenium(II) complexes containing various pyridine‐functionalized NHC ligand chelating bipyridyl ligands (e.g., 2,2′‐bipyridine, 5,5′‐dimethyl‐2,2′‐bipyridine, 1,10‐phenanthroline (phen)). The were well characterized by NMR, electrospray ionization‐mass spectrometry, single‐crystal X‐ray structure analyses. Among the new derivatives, identified that complex Ru8 bearing...
Introduction: Benzalkonium chloride (BAC) is widely employed as a preservative in eye drops, which will cause the death of corneal epithelial cells due to ROS production, DNA strand breakage, and mitochondrial dysfunction, resulting dry disease (DED)-like changes ocular surface tissues. In this study, Melatonin (MT) liposomes (TAT-MT-LIPs) designed by loading MT into TAT-modified have been developed, characterized, used for inhibiting BAC-induced DED (BAC-DED). Methods: The TAT was...
Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential cell-based tools for treatment SSc.BMSCs were isolated from bone mice identified with surface markers according to multilineage differentiation. EVs BMSC culture medium by ultracentrifugation Nanosight NS300 particle size analyzer, transmission electron microscopy (TEM), western blot. The...
To study the biological functions and applications of human amniotic epithelial cell-derived extracellular vesicles (hAEC-EVs), cargos hAEC-EVs were analyzed using miRNA sequencing proteomics analysis. The hAECs in this had specific characteristics. Multi-omics analyses showed that matrix (ECM) reorganization, inhibition excessive myofibroblasts, promotion target cell adhesion to ECM their primary functions. We evaluated application for corneal alkali burn healing rabbits elucidated...
In this study, we conducted an in-depth exploration of Alzheimer's Disease (AD) by integrating state-of-the-art methodologies, including single-cell RNA sequencing (scRNA-seq), weighted gene co-expression network analysis (WGCNA), and a convolutional neural (CNN) model. Focusing on the pivotal role microglia in AD pathology, our revealed 11 distinct microglial subclusters, with 4 exhibiting obviously alterations HC groups. The investigation cell–cell communication networks unveiled intricate...
Fever in children is one of the most common clinical symptoms and a chief complaint main reason that caregivers took to outpatient service or admitted hospital. Studies have found majority parents surveyed at hospital pediatric clinic held unrealistic unwarranted concerns about fevers, first termed as 'fever phobia' by Schmitt 1980. In present study, we explore whether exists Chinese investigate such phobia alleviated when after propaganda fever related knowledge doctors nurses. A...
Abstract: Sepsis, which is caused by severe infection, an important cause of mortality, but effective clinical treatment against sepsis extremely limited. As the main component outer membrane Gram-negative bacteria, lipopolysaccharide (LPS) plays a major role in inflammatory responses. Studies have shown beneficial pharmacological effects for Folium isatidis. The present study further illuminated n -butanol extract from isatidis LPS-induced septic shock and identified active chemical...
Background Systemic sclerosis (SSc) is a rare autoimmune disease characterized by extensive skin fibrosis. There are no effective treatments due to the severity, multiorgan presentation, and variable outcomes of disease. Here, integrated bioinformatics was employed discover tissue-specific expressed hub genes associated with SSc, determine potential competing endogenous RNAs (ceRNA) regulatory networks, identify targeted drugs. Methods In this study, four datasets SSc were acquired. To...
Rationale: Prodrug strategies that render the drug temporarily inactive through a cleavable linkage are able to modulate physicochemical properties of drugs for adaptive nanoparticle (NP) formulation. Here we used cabazitaxel as model compound test validity our "balancing NP stability and specific activation" strategy. Methods: Cabazitaxel is conjugated hydrophobic polylactide fragments with varying chain lengths via self-immolation linkage, yielding polymeric prodrugs can be reactivated by...
An efficient approach for 1,2-difunctionalization of aromatic olefins and the synthesis functionalized 1,4-diols monoethers has been established via a photoinduced three-component reaction an α-alkoxycarboxylic acid, olefin, aldehyde. The proceeds by oxidative decarboxylation carboxylic acid followed addition α-alkoxyalkyl radical to one-electron reduction radical, nucleophilic attack resulting carbanion Besides convenient one-pot protocol reaction, this method offers several other...
Nanoparticles self-assembled by amphiphilic copolymers for loading hydrophobic molecules are intensively investigated. However, their molecule-loading capacity is low due to the limitation of groups in these copolymers. In this regard, new lysine oligomer-based multi-hydrophobic side chain polymers (MHCPs) synthesized polymerization γ-benzyl-l glutamate N-carboxy anhydride initiated side-chain primary amino oligomer. Each MHCPs can be interaction form multi-hydrophobic-core nanoparticles...
Abstract The prevalence of hypertension has increased rapidly in recent years. Currently, increasing attention been paid to the relationship between and platelet abnormalities. As a simple available parameter, distribution width (PDW) can reflect abnormalities further risk thrombotic diseases. However, views on PDW are controversial at present studies. Hence, we aimed find associations subtypes study. A total 73,469 participants (44,665 males 28,804 females) were enrolled. We found that was...
Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle-wasting disease caused by a mutation in the DMD gene. The aim of this study was to identify de novo gene family 9-month-old Chinese male patient, as well describe phenotypic characteristics patient. patient suspected suffer from according physical examination, biochemical analyses, and electromyogram. We identified duplication exons 4–42 with targeted exome sequencing multiplex ligation-dependent probe amplification (MLPA). In...
Neutrophils, immune cells crucial for protecting against invading pathogens, are important in sepsis. Neutrophil migration is regulated by chemokine receptors and their cognate ligands. Our previous study investigated the effect of n‑butanol extract from Folium isatidis on lipopolysaccharide (LPS)‑induced septic shock. The present stimulated neutrophils with LPS to explore influence cell. Neutrophils were then pretreated followed examine this neutrophil chemotaxis. results showed that...