A5102912080- Nanoparticle-Based Drug Delivery
- Cancer Treatment and Pharmacology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Metal complexes synthesis and properties
- Ocular Surface and Contact Lens
- Advanced Drug Delivery Systems
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- Nanoplatforms for cancer theranostics
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Circular RNAs in diseases
- Adsorption and biosorption for pollutant removal
- Metabolism, Diabetes, and Cancer
- Polymer Surface Interaction Studies
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Cancer Mechanisms and Therapy
- Heavy metals in environment
- Cancer Immunotherapy and Biomarkers
Zhejiang University
2016-2024
Sir Run Run Shaw Hospital
2016-2024
Guangxi Medical University
2019-2023
Dalian Medical University
2021-2023
Chongqing Medical University
2021-2023
Second Affiliated Hospital of Chongqing Medical University
2021-2023
Jinan University
2021-2022
Blood Center of Zhejiang Province
2021
National Health and Family Planning Commission
2021
First Affiliated Hospital Zhejiang University
2021
Purpose: Colitis-associated colorectal cancer (CAC) poses substantial challenges for effective treatment.Currently, there is a considerable need the development of orally bioavailable dosage forms that enable safe and delivery therapeutic drugs to local diseased lesions in gastrointestinal tract.Experimental Design: In this study, we developed deliverable nanotherapeutics synergistic treatment inflammatory bowel diseases (IBDs) CAC.Water-insoluble curcumin (CUR)...
The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand strategies treat various diseases. Numerous synthetic nanoparticles have been developed pharmaceutical delivery cancer treatment. However, only a limited number nanotherapies enter clinical trials or are clinically approved. Systemically administered likely be sequestered by host...
Colitis-associated colorectal cancer (CAC) develops from chronic intestinal inflammation. Dihydroartemisinin (DHA) is an antimalarial drug exhibiting anti-inflammatory and anti-tumor effects. Nonetheless, the therapeutic effects of DHA on CAC remain unestablished. Methods: Mice were challenged with azoxymethane (AOM) dextran sulfate sodium (DSS) to establish models. was administered via oral gavage in different stages Colon tumor tissues obtained AOM/DSS models investigate inflammatory...
The simultaneous presence of heavy metals and organic acids in nature wastewaters their competition for adsorption sites determine the migration, transformation fate pollutants environment. A Cd2+-ion-imprinted polymer (Cd2+-IIP) with a thiol-functional group was hydrothermally synthesized by surface imprinting technique combined ultrasonic heating selective Cd2+ from wastewaters. adsorbent characterized SEM, EDS, XPS, BET FT-IR measurements. experimental results concerning single-, binary-,...
Taxane-based chemotherapeutics are clinically available as frontline treatment regimens for cervical cancer. However, drug resistance and life-threatening toxicity impair the clinical efficacy of taxanes, so more effective less toxic therapeutic modalities urgently needed. Cabazitaxel has attracted increasing interest due to its potential circumvent by taxanes. We previously showed that tethering docosahexaenoic acid (DHA) cabazitaxel enabled prodrug self-assemble into nanoparticles in...
Background Many existing studies indicated that patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s (CD), tend to have the risk of low total body bone mineral density (BMD), are more likely osteoporosis (OS). To determine causal relationship between IBD metabolic disorders, we herein performed a two-sample Mendelian randomization analysis (TSMR) using publicly available summary statistics. Methods Summary statistics BMD, OS were downloaded from Open...
Polymer scaffolds intended to provide a substrate for cell attachment and proliferation benefit if the geometric architecture, mechanical properties, surface chemistry are controllable within range applicable target tissue. Such may be made bioinductive through inclusion of proteins release growth factors. Furthermore, polymer support formed biodegradable polymers use as tissue-engineering scaffolds. In this study, new scaffold-fabrication technique based on direct writing...
Biofouling is of great concern in numerous applications ranging from ophthalmological implants to catheters, and bioseparation biosensors. In this report, a general facile strategy combat surface fouling developed by grafting amino acids onto polymer substrates form zwitterionic structure through groups induced epoxy ring opening click reaction. First all, library poly(2-hydroxyethyl methacrylate-co-glycidyl methacrylate) hydrogels with surfaces were prepared, resulting the formation pairs...
Abstract Right-sided colon cancer (RCC) and left-sided (LCC) differ in their clinical molecular features. An investigation of differentially expressed genes (DEGs) between RCC LCC could contribute to targeted therapy for cancer, especially RCC, which has a poor prognosis. Here, we identified HOXB13, was significantly less than associated with prognosis by using 5 datasets from the Gene Expression Omnibus (GEO). Tissue sample analysis showed that HOXB13 normal only tumor tissues. inhibited...
In this study, we designed and synthesized four novel multi-nuclear silver complexes (1-4) coordinated with pyrazole- or pyridine-functionalized N-heterocyclic carbene (NHC) ligands. The crystal structures of the silver-NHC were confirmed by X-ray diffraction analysis. vitro assays showed that effectively killed a broad range cancer cells after short-term drug exposure, serving as fast-acting cytotoxic agents. Of note, in cisplatin-resistant A549 cells, not cross-resistant clinically used...