A5032467698- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Chemotherapy-induced organ toxicity mitigation
- Data Stream Mining Techniques
- Cancer, Lipids, and Metabolism
- Anorectal Disease Treatments and Outcomes
- Renal and related cancers
- Gout, Hyperuricemia, Uric Acid
- Vasculitis and related conditions
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
Sir Run Run Shaw Hospital
2018-2024
Zhejiang University
2018-2024
Fuzhou University
2023
Institute of Food Science and Technology
2023
Changzhou No.2 People's Hospital
2021-2023
Nanjing Medical University
2021-2023
Northeastern University
2021
Second Affiliated Hospital of Fujian Medical University
2021
Fujian Medical University
2021
Johns Hopkins University
2020
Colitis-associated colorectal cancer (CAC) develops from chronic intestinal inflammation. Dihydroartemisinin (DHA) is an antimalarial drug exhibiting anti-inflammatory and anti-tumor effects. Nonetheless, the therapeutic effects of DHA on CAC remain unestablished. Methods: Mice were challenged with azoxymethane (AOM) dextran sulfate sodium (DSS) to establish models. was administered via oral gavage in different stages Colon tumor tissues obtained AOM/DSS models investigate inflammatory...
Abstract Right-sided colon cancer (RCC) and left-sided (LCC) differ in their clinical molecular features. An investigation of differentially expressed genes (DEGs) between RCC LCC could contribute to targeted therapy for cancer, especially RCC, which has a poor prognosis. Here, we identified HOXB13, was significantly less than associated with prognosis by using 5 datasets from the Gene Expression Omnibus (GEO). Tissue sample analysis showed that HOXB13 normal only tumor tissues. inhibited...
Abstract Background Cancer metastasis is still a life threat to patients with colorectal cancer (CRC). Brain and muscle ARNT‐like protein 1 (BMAL1) an important biological proteins that can regulate the behavior of cells their response chemotherapy. However, role BMAL1 in tumorigenic phenotype CRC remains unclear. Here, we aim investigate functional mechanisms CRC. Methods The mRNA expression was studied using Genome Atlas (TCGA) databases. level clinical tissues confirmed by...
Background/Aim: In earlier research, we demonstrated that pyrvinium pamoate (PP) can effectively inhibit the proliferation and migration of colorectal cancer (CRC) cells. current study, further explore possibility PP, as a potential therapeutic drug in treatment CRC. Materials Methods: Hoechst 33258 staining, immunofluorescence, western blotting were used to investigate connection between PP CRC cell apoptosis autophagy. Results: We found promoted autophagy At protein level, expression...
Abstract Posttranslational modifications (PTMs) of proteins, particularly acetylation, phosphorylation, and ubiquitination, play critical roles in the host innate immune response. PTMs’ dynamic changes crosstalk among them are complicated. To build a comprehensive network inflammation-related we integrated data from whole-cell proteome (WCP), acetylome, phosphoproteome, ubiquitinome human mouse macrophages. Our datasets ubiquitination sites helped identify PTM within across proteins involved...
Head and neck squamous cell carcinoma (HNSCC) is one of the most malignant cancers with poor prognosis worldwide. Emerging evidence indicates that competing endogenous RNAs (ceRNAs) are involved in various diseases, however, regulatory mechanisms ceRNAs underlying HNSCC remain unclear. In this study, we retrieved differentially expressed long non-coding (DElncRNAs), messenger (DEmRNAs) microRANs (DEmiRNAs) from The Cancer Genome Atlas database constructed a ceRNA-based risk model by...
Cancer-associated fibroblasts (CAFs) are notably involved in colorectal cancer (CRC) tumorigenesis, progression, and treatment failure. In this article, we report the silico development of a CAF-related prognostic signature for CRC.We separately downloaded CRC transcription data from The Cancer Genome Atlas Gene Expression Omnibus database. Deconvolution algorithms, including Estimating Proportions Immune Cells Microenvironment Cell Population-counter, were used to calculate CAF abundance,...
Clear cell renal carcinoma (ccRCC) is a major histological subtype of and can be clinically divided into four stages according to the TNM criteria. Identifying clinical stage-related genes beneficial for improving early diagnosis prognosis ccRCC. By using bioinformatics analysis, we aim identify stage-relevant that are significantly associated with development First, analyzed gene expression microarray data sets: GSE53757 GSE73731. We these five groups by staging information—normal tissue...
In the current era of precision medicine, there is a general consensus that anatomical site an important factor in management colorectal cancer (CRC). To investigate underlying molecular mechanisms between proximal and distal CRC to identify responsible genes, we analyzed gene expression patterns tumors from two microarray datasets, GSE39582 GSE14333, on NCBI Gene Expression Omnibus RNA‑seq data TCGA. Weighted coexpression network analysis (WGCNA) was applied construct network. The red...
Background: Conventional neoadjuvant chemoradiotherapy (nCRT) yields a pathologic complete response (pCR) rate of 15%–30% for locally advanced rectal cancer (LARC). This study ventures to shift this paradigm by incorporating short-course nCRT with immunotherapy, specifically Envafolimab, achieve improved treatment efficacy and possibly redefine the standard care LARC. Materials methods: The PRECAM is prospective, single-arm, phase 2 clinical trial LARC in patients microsatellite stable (MSS)...
Peritoneal metastasis from colorectal cancer (CRC) is related to poor prognosis. Intraperitoneal chemotherapy an efficient method treat peritoneal (PM); however, the outcomes remain unsatisfactory. The present study aimed investigate antitumor activity of lobaplatin and its role in intraperitoneal chemotherapy. findings showed that proliferation CRC was inhibited a dose-dependent manner when DLD1 HCT116 cells were treated with various concentrations (0, 6.3, 12.5, 25, 50, 100 μg/mL,...
In our previous study, it was reported that 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol (2,3-DCPE) induces apoptosis and cell cycle arrest. The current study aimed to investigate the molecular mechanism involved in 2,3-DCPE-induced S phase results demonstrated 2,3-DCPE upregulated phosphorylated (p-)H2A histone family member X, a biomarker of DNA damage, DLD-1 colon cancer line. Western blotting revealed increased checkpoint kinase (Chk)1 (Ser317 Ser345) level decreased expression M-phase...
Abstract The use of the anthelmintic drug pyrvinium pamoate (PP) in cancer therapy has been extensively investigated last decade. PP shown to have an inhibitory effect colorectal (CRC), but underlying mechanism remains elusive. We aimed investigate antitumor activity and mechanisms CRC. In present study, we used CCK-8 assays, colony formation western blotting reveal that effectively suppressed CRC cell proliferation AKT-dependent signaling pathway a concentration-dependent time-dependent...
Background: Henoch-Schonlein purpura (HSP) is a common capillary allergic bleeding disease. To explore the variation of pyroptosis-related inflammatory factors level in peripheral blood patients with HSP.
Carcinoembryonic antigen (CEA) is a cancer biomarker used in colorectal (CRC) for tumor screening and outcome prediction. However it still lack of sensitivity specificity general population. The present study aimed to investigate the clinical significance CEA patients with normal preoperative levels.Ninety-four were included who received surgery developed an elevated level postoperatively. They divided into group A1 A2 according peak (whether more than 10 ng/mL); B1 B2 variation reached at...
Vonoprazan (VPZ)-based regimens are an effective first-line therapy for Helicobacter pylori (H. pylori) infection. However, their value as a rescue needs to be explored.To assess VPZ-based regimen H. therapy.This prospective, single-center, clinical trial was conducted between January and August 2022. Patients with history of treatment failure were administered 20 mg VPZ twice daily, 750 amoxicillin 3 times 250 Saccharomyces boulardii (S. boulardii) daily 14 d (14-d VAS regimen). S. taken...
3614 Background: Conventional neoadjuvant chemoradiotherapy (nCRT) yields a pathologic complete response (pCR) rate of about 15%–- 30% for locally advanced rectal cancer (LARC). This PRECAM study aimed to investigate the efficacy and safety short-course radiotherapy combined with CAPEOX plus Envafolimab in Patients Microsatellite Stable (MSS) LARC, redefining standard care (SOC) LARC. Methods: The is an open-label, prospective, single-arm, phase II clinical . Eligible patients MSS LARC were...
To analyze whether the European Organisation for Treatment and Research of Cancer (EORTC) Quality Life Questionnaires (QLQ-C30 QLQ-CR29) complement low anterior resection rectum syndrome (LARS) score in evaluating quality life patients who underwent laparoscopic or robotic rectal cancer surgery. Initially, 335 surgery were randomly selected at Sir Run Shaw Hospital, Zhejiang University School Medicine from June 2013 to September 2020. All took questionnaires LARS score, QLQ-C30 QLQ-CR29....
Rectal leiomyosarcoma is a rare neoplasm, and no standard therapeutic strategy has been established, other than surgical resection. The prognosis of advanced in the rectum poor. We describe case 47-year-old man with locally rectal who presented anal bleeding lower abdominal pain. After discussions by multidisciplinary team (MDT), patient received preoperative pelvic short-course radiotherapy followed laparoscopic-assisted abdominoperineal Adjuvant chemotherapy doxorubicin ifosfamide was...
Abstract The posttranslational modification (PTM) of proteins, particularly acetylation, phosphorylation and ubiquitination, plays a critical role in the host innate immune response. PTMs’ dynamic changes crosstalk among them are complicated. To build comprehensive network inflammation related we integrated data from whole cell proteome (WCP), acetylome, phosphoproteome ubiquitinome human mouse macrophages. Our datasets ubiquitination sites helped identify PTM within across proteins involved...