A5069720473- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cytokine Signaling Pathways and Interactions
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Pelvic floor disorders treatments
- Acute Myocardial Infarction Research
- Nutrition and Health in Aging
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Esophageal Cancer Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Diet, Metabolism, and Disease
- Studies on Chitinases and Chitosanases
- Venous Thromboembolism Diagnosis and Management
- Bone health and osteoporosis research
- Nausea and vomiting management
- Invertebrate Immune Response Mechanisms
Sir Run Run Shaw Hospital
2019-2024
Zhejiang University
2015-2024
Blood Center of Zhejiang Province
2019-2022
Purpose5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in for patients with advanced colorectal cancer, but many still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed the important role of chemokine (C-X-C motif) ligand 13 (CXCL-13) tumor microenvironment and its relationship prognosis cancer. This study designed reveal CXCL-13 causing cancer resistance 5-Fu.Materials MethodsCXCL-13 levels patient's serum or cell culture supernatants...
Anastomotic stenosis is a common complication of colorectal cancer surgery with anastomosis. Transanal minimally invasive novel approach to the treatment anastomotic stenosis.This study aimed evaluate efficacy and safety transanal for treatment.This was retrospective study.This conducted at comprehensive center.This included patients rectal who after undergoing were admitted Sir Run Shaw Hospital between September 2017 June 2019.The primary outcome operative success rate. The secondary...
Background: Conventional neoadjuvant chemoradiotherapy (nCRT) yields a pathologic complete response (pCR) rate of 15%–30% for locally advanced rectal cancer (LARC). This study ventures to shift this paradigm by incorporating short-course nCRT with immunotherapy, specifically Envafolimab, achieve improved treatment efficacy and possibly redefine the standard care LARC. Materials methods: The PRECAM is prospective, single-arm, phase 2 clinical trial LARC in patients microsatellite stable (MSS)...
134 Background: Chemoradiation is the standard neoadjuvant treatment for locally advanced rectal cancer. Microsatellite stable (MSS)/ mismatch repair proficient (pMMR) cancer rarely responds to immune checkpoint inhibitor monotherapy, but combination with chemoradiation may improve sensitivity of MSS/pMMR tumors by inducing immune-stimulatory effects. Therefore, we aimed investigate efficacy and safety patients treated preoperative short-course radiation followed envafolimab plus CAPEOX...
This study aimed to evaluate the value of chitinase activity in prognosticating occurrence metastasis and prognosis patients with colorectal cancer (CRC).The four different groups, namely 335 CRC without distant at their first visit (Group 1), 51 having synchronous liver 2), 100 healthy age-matched controls 3) 40 4), were assayed using an enzyme-linked immunosorbent assay. The Cox proportional hazards ratio model Kaplan-Meier curve used identify association between clinical outcome training...
The role of palliative primary tumor resection (PPTR) in improving survival patients with synchronous unresectable metastatic colorectal cancer (mCRC) is controversial. In this study, we aimed to evaluate whether our novel scoring system could predict benefits PPTR mCRC patients.In retrospective cohort study consecutive and metastases admitted Sir Run Shaw Hospital between January 2005 December 2013 were identified. A was established by the serum levels carcinoembryonic antigen (CEA), 19-9...
Introduction: Primary colorectal angiosarcoma is a highly rare malignant tumor. There no standard treatment method for this disease. No of rectal with apatinib has been reported so far. Case Presentation: In the current study, an 87-year-old male presented symptoms frequent defecation more than one month in Hangzhou, China, 2018. The patient was initially diagnosed stromal underwent ultrasound-guided transrectal mass puncture next treatment. However, immunohistochemical examinations...
Abstract Background Low anterior resection syndrome (LARS) is a distressing condition that affects approximately 25–80% of patients following surgery for rectal cancer. LARS characterized by debilitating bowel dysfunction symptoms, including fecal incontinence, urgent movements, and increased frequency movements. Although biofeedback therapy has demonstrated effectiveness in improving postoperative control, the research results have not fulfilled expectations. Recent highlighted stimulating...
Robotic-assisted surgery (RAS) is increasingly used for treating low rectal cancer. Its comparative effectiveness against laparoscopic (LAS) in enhancing long-term anal function remains uncertain.
Background Anastomotic stricture (AS) is a common complication following rectal cancer surgery with anastomosis, but its diagnosis and management pose significant challenges due to the lack of standardized diagnostic criteria. We present case highlighting complexities encountered in diagnosing managing occult AS post-rectal surgery. Case presentation A 51-year-old male patient presented symptoms suggestive robot-assisted laparoscopic low anterior resection for adenocarcinoma. Despite...
Objective This study aims to explore the association between risk stratification and total occlusion (TO) of culprit artery multivessel disease (MVD) in patients with non-ST-segment-elevation myocardial infarction (NSTEMI) obtain more data on clinical decision-making addition stratification. Methods We retrospectively collected from 835 NSTEMI admitted our hospital 1 January 2016 August 2022. All underwent percutaneous coronary intervention (PCI) within 72 h admission. excluded a history...
An association between the methylenetetrahydrofolate reductase (MTHFR) C667T genotype and risk of colorectal cancer, as well a link MTHFR gene polymorphism thrombosis, have been revealed. However, connection thrombosis in patients with cancer has remained to be fully elucidated. The present study investigated basic clinical data, postoperative D-dimer (DDi), thromboelastogram 591 who underwent surgery for cancer. Postoperative DDi, were not significantly different among genotypes. While...
Colonoscopic polypectomy is extremely effective in protecting against colorectal cancers, and recognition of adenomas by colonoscopy paramount importance preventing cancer (CRC) CRC-associated mortality. Incomplete polyp resection (IPR) occurs routinely medical practice following polypectomy. We conducted a comprehensive literature search to identify studies that reported on the potential risk factors for IPR using MEDLINE, EMBASE, PubMed. Publication time was limited between January 2004...