A5101641178- Ubiquitin and proteasome pathways
- interferon and immune responses
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Inflammatory Bowel Disease
- Ginger and Zingiberaceae research
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Bioactive natural compounds
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2020-2021
Zhejiang University
2020-2021
Nanjing University of Chinese Medicine
2020
National Clinical Research
2020
Huazhong University of Science and Technology
2017-2019
Abstract Posttranslational modifications (PTMs) of proteins, particularly acetylation, phosphorylation, and ubiquitination, play critical roles in the host innate immune response. PTMs’ dynamic changes crosstalk among them are complicated. To build a comprehensive network inflammation-related we integrated data from whole-cell proteome (WCP), acetylome, phosphoproteome, ubiquitinome human mouse macrophages. Our datasets ubiquitination sites helped identify PTM within across proteins involved...
Two new N-acetyldopamine tetrapolymers, cicadamide A (1) and B (2), were isolated from Periostracum Cicadae, their structures elucidated as 3-acetylamino-7-(3″-acetylamino-7″-(N-acetyl-2‴-aminoethyl)-1″,4″-benzodioxan-2″-yl)-2-(2′-(3″″,4″″-dihydroxyphenyl)-3′-acetylamino-1′,4′-benzodioxan-7′-yl)-1,4-benzodioxane 3-acetylamino-7-(3″-acetylamino-6″-(N-acetyl-2‴-aminoethyl)-1″,4″-benzodioxan-2″-yl)-2-(2′-(3″″,4″″-dihydroxyphenyl)-3′-acetylamino-1′,4′-benzodioxan-7′-yl)-1,4-benzodioxane by the...
Primary hepatocytes (PHCs) are widely used in various fields, but the progressive deterioration of liver-specific features vitro significantly limits their application. While transcriptional regulation and whole cell proteome (WCP) PHCs have been extensively studied, only a small number studies addressed role posttranslational modifications this process. To elucidate underlying mechanisms that induce dedifferentiation, we carried out parallel quantifications transcriptome, WCP, ubiquitinome,...
Abstract The posttranslational modification (PTM) of proteins, particularly acetylation, phosphorylation and ubiquitination, plays a critical role in the host innate immune response. PTMs’ dynamic changes crosstalk among them are complicated. To build comprehensive network inflammation related we integrated data from whole cell proteome (WCP), acetylome, phosphoproteome ubiquitinome human mouse macrophages. Our datasets ubiquitination sites helped identify PTM within across proteins involved...
Abstract Background: Drug resistance has become the main reason for failure of tumor chemotherapy. In our previous study, ophiopogonin B (OP-B) been verified to inhibit cell proliferation in numerous non-small lung cancer (NSCLC) cells. However, it is still unknown whether can improve drug Herein, we compared inhibition effects OP-B on NCI-H460, A549, A549/DDP and A549/PTX cells, tried find out most sensible line underlying reasons. Methods: The sensitivity A549/DDP, cells was determined by...