A5100652142- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Acute Ischemic Stroke Management
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Pesticide Exposure and Toxicity
- Pancreatic and Hepatic Oncology Research
- Photodynamic Therapy Research Studies
- Poisoning and overdose treatments
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Microtubule and mitosis dynamics
- Diabetic Foot Ulcer Assessment and Management
- Advanced Breast Cancer Therapies
- Spinal Hematomas and Complications
- DNA Repair Mechanisms
- HER2/EGFR in Cancer Research
- Folate and B Vitamins Research
- Immunotoxicology and immune responses
Jinan Central Hospital
2024
Shandong University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Soochow University
2020-2022
Second Affiliated Hospital of Soochow University
2022
Affiliated Hospital of Nantong University
2009-2022
Nantong University
2009-2022
Second Affiliated Hospital of Nantong University
2009-2022
Weatherford College
2021
Zhejiang University
2021
Statement of RetractionWe, the Editors and Publisher journal Cell Cycle, have retracted following articleChao Liu, Zhiping Feng, Ting Chen, Juan Lv, Pengjie Li Jia, Jialun Zhu, Fukun Chuanzhou Yang, Zhiyong Deng. Downregulation NEAT1 reverses radioactive iodine resistance papillary thyroid carcinoma cell via miR-101-3p/FN1/PI3K-AKT signaling pathway. Cycle. 2018;18(2):167–203. doi: 10.1080/15384101.2018.1560203.Since publication, concerns been raised about integrity data in article. When...
Aim The aim was too study the correlations between blood lipid, serum cystatin C (Cys C) and homocysteine (Hcy) levels in patients with Parkinson's disease (PD). Methods A total of 322 PD 214 healthy subjects were selected as case control groups, respectively. risk factors explored by logistic regression analysis. group subtyped according to main motor symptoms age onset. significantly different indices age, duration disease, equivalent dose levodopa studied Spearman's correlation Receiver...
Abstract Background Recently, long non-coding RNAs (lncRNAs) have been reported to be involved in regulating chemo-resistance of NSCLC, however, the role lncRNA SNHG14 DDP-resistance NSCLC remains unexplored. Methods Relative expression SNHG14, HOXB13 and miR-133a DDP-resistant A549 (A549/DDP) cell its parental were measured using qRT-PCR. Cell proliferation viability indicated A549/DDP was estimated via CCK-8 colony formation experiments. cycle apoptosis analyzed through flow cytometry....
Despite the considerable knowledge on involvement of microRNA-101 (miR-101) in evolution oral squamous cell carcinoma (OSCC), underlying mechanisms remain obscure. In this study, miR-101 expression was markedly downregulated OSCC lines and tissues. Cell counting kit-8 (CCK-8), ethynyl deoxyuridine (EdU), colony formation assays showed that inhibited proliferation cells. Flow cytometry caspase 3 activity indicated induced apoptosis. Transwell demonstrated miRNA also repressed migration...
Head and neck squamous cell carcinoma (HNSCC) is one of the most malignant cancers with poor prognosis worldwide. Emerging evidence indicates that competing endogenous RNAs (ceRNAs) are involved in various diseases, however, regulatory mechanisms ceRNAs underlying HNSCC remain unclear. In this study, we retrieved differentially expressed long non-coding (DElncRNAs), messenger (DEmRNAs) microRANs (DEmiRNAs) from The Cancer Genome Atlas database constructed a ceRNA-based risk model by...
Abstract Pancreatic ductal adenocarcinoma (PDAC), a common malignancy originated from the digestive system worldwide, has poor clinical outcome. SPOCK1 is widely investigated member of Ca 2+ ‐binding proteoglycan family and functions as an essential driver in several cancers. However, complex regulatory role PDAC unclear. Bioinformatics analysis predicted interrelationship between increased expression characteristics patients with PDAC. The levels fresh tissue samples were confirmed, was...
Introduction: Increasing evidence has indicated that LINC00680 represents an oncogenic factor in cancer; however, the mechanism by which contributes to breast cancer (BC) remains unknown. Methods: A dual-luciferase reporter assay was used explore relationship between LINC00680, miR-320b, and cyclin-dependent kinase 5 (CDKL5). CCK-8 transwell were utilized evaluate proliferation invasion docetaxel-resistant BC cells, respectively. Results: CDKL5 protein levels both upregulated when induced...
Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, and disulfidptosis a newly discovered mechanism programmed cell death. However, effects disulfidptosis‑related lncRNAs (DR‑lncRNAs) in LUAD have yet to be fully elucidated. The aim present study was identify validate novel lncRNA‑based prognostic marker that associated with disulfidptosis. RNA‑sequencing clinical data were obtained from Cancer Genome Atlas database. Univariate Cox regression lasso algorithm...
Long non-coding RNAs (lncRNAs) play an important role in various biological processes of lung adenocarcinoma (LUAD), such as immune response regulation, tumor microenvironment remodeling and genomic alteration.Nevertheless, immune-related lncRNAs their alterations characteristics LUAD samples still remain unreported.Here, using public databases, statistic software tools, we constructed two lncRNA clusters with different characteristics.Notably, cluster 1 had a stronger immunosuppressive...
To the Editor: Parkinson's disease (PD) is second most common neurodegenerative disorder, and sleep disturbance a major disabling non-motor symptom.[1] Excessive daytime sleepiness (EDS) defined as inappropriate undesirable during waking hours, which may occur activities such talking or driving. In PD patients, EDS increased risk of accidents resulted in poor quality life.[2] Selegiline selective, irreversible monoamine oxidase type B (MAO-B) inhibitor, improves motor symptoms posture gait...
To studied epidemiological characteristics of 493 cases acute poisoning in Nantong city, Jiangsu province.Based on the analysis platform treatment, adopted single center and prospective investigation method, analyzed data patients from May 2015 to December 2018 second affiliated hospital University.Among with poisoning, men 227 (46.04%), women 266 (53.96%). Age ranged 12 89 years old, average age 41.6 years. In occupational distribution, farmers were 30.02%; 351 (71.20%) visited within 6...
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Abstract BackgroundThe purpose of this study was to explore regulatory mechanism the long non-coding RNA LINC00680 underlying breast cancer chemoresistance via miR-205/CDKL5 axis. MethodsBioinformatics methods were applied screen lncRNAs, miRNAs and mRNAs for construction a competing endogenous network. Dual-luciferase reporter assay used relationship between LINC00680, miR-320b CDKL5. CCK-8 Transwell utilized evaluate proliferation, migration invasion in docetaxel-resistant...
Objective To explore the expression of miR-518b in invasive ductal breast cancer and analyze its impact on proliferation,cell cycle,apoptosis invasion MCF-7 cell line.Methods Twenty pairs normal tissue specimens were chosen after confirmation carcinoma.We conducted reverse transcription-polymerase chain reaction (RT-PCR) to quantify miR-518b,and correlation with clinical data was analyzed by using SPSS software 13.0.To characterize effect cells,functional assays respectively...
Objective To investigate the effects of hyperbaric oxygen （HBO） therapy on serum matrix metalloproteinase-9 （MMP-9） and intercellular adhesion molecule-1 （ICAM-1） levels, brain edema in patients with intracerebral hemorrhage. Methods Seventy-six subjects hemorrhage were divided into a routine treatment group （40 cases） a.HBO （36 cases）. 30 healthy persons served as control group. Serum MMP-9 ICAM-1 levels measured before after treatment. MRI images subjects＇ brains prepared at 5 -7 th 25th...
Objective To study the effects of hyperbaric oxygen (HBO) therapy on contents serum high sensitivity C-reactive protein ( hs-CRP ) and blood glucose BG in patients with intracerebral hemorrhage. Methods One hundred twelve were selected as subjects, divided into routine treatment group (57 cases) HBO (55 cases), 50 healthy subjects chosen control.Then, observations made before after therapy.The therapeutic efficacy was evaluated by scores neurologic impairment (NIHSS) activities daily life...
Abstract Background: Prostate cancer (PCa) is the most commonly diagnosed for men in United States. Most of PSA screening-detected PCa are slow-growing and not life-threatening. However, majority PSA-detected receive aggressive treatment, which often associated with significant morbidity. Clinical variables, such as Gleason Score (GS), level, tumor stage, sufficient to distinguish from indolent diseases at diagnosis. Biomarkers urgently needed more accurate prediction individual behavior...
To develop a pirarubicin (THP) and vinorelbine (VRL) codelivery nano-micellar system (T+V-CS micelles) of by using chondroitin sulfate-cholesterol polymers (CS-Chol) DSPE-mPEG 2000 to evaluate the therapeutic efficacy nano-micelles in breast cancer treatment.T+V-CS micelles were prepared ultrasonic-dialysis method, physicochemical characterization evaluated multiple technological means. The anti-tumor T+V-CS vitro was MTT assay cell cycle arrest analysis. Evaluation effect vivo carried out...