A5011117741- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Botulinum Toxin and Related Neurological Disorders
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Sleep and related disorders
- Nerve injury and regeneration
- Cerebral Palsy and Movement Disorders
- Pain Mechanisms and Treatments
- Retinal Development and Disorders
- Obstructive Sleep Apnea Research
- Advanced Neuroimaging Techniques and Applications
- Olfactory and Sensory Function Studies
- Retinal Diseases and Treatments
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- RNA regulation and disease
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Neurological diseases and metabolism
- Vestibular and auditory disorders
Soochow University
2016-2025
Second Affiliated Hospital of Soochow University
2016-2025
Duke University
2021-2025
South China Normal University
2022-2024
Soochow University
2023
University of Electronic Science and Technology of China
2023
Douglas Mental Health University Institute
2023
McGill University
2023
Zhejiang Lab
2023
Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, role in microglia polarization neuroinflammation is poorly understood. TNF-α, which highly toxic dopaminergic neurons, implicated a major mediator PD. In this study, we found that TNF-α resulted an impairment autophagic flux microglia. Concomitantly, increase M1 marker (iNOS/NO, IL-1β, IL-6) expression reduction M2 (Arginase1, Ym1/2, IL-10) were...
Abstract Inflammation is one of the pathogenic processes in Parkinson’s disease (PD). Dopamine receptor agonist pramipexole (PPX) extensively used for PD treatment clinics. A number studies show that PPX exerts neuroprotection on dopaminergic (DA) neurons, but molecular mechanisms underlying protective effects DA neurons are not fully elucidated. In present study, we investigated whether modulated PD-related neuroinflammation and mechanisms. model was established mice by bilateral striatum...
It is urgently needed to find reliable biofluid biomarkers for early diagnosis of Parkinson's disease in order achieve better treatment. Promising can be found disease-related glycoproteins as aberrant protein glycosylation plays an important role progression. However, current information on serum N-glycoproteomic changes still limited. Here, we used glycoproteomics methods, which combine the solid-phase chemoenzymatic method, lectin affinity chromatography, and hydrophilic interaction...
Metal-halide perovskites (MHPs) are attracting considerable interest for optoelectronic applications, with <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline" overflow="scroll"><a:msub><a:mi>Cs</a:mi><a:mn>2</a:mn></a:msub><a:msub><a:mrow><a:mi>Ag</a:mi><a:mi>Bi</a:mi><a:mi>Br</a:mi></a:mrow><a:mn>6</a:mn></a:msub></a:math> one of the main contenders among lead-free systems. <d:math xmlns:d="http://www.w3.org/1998/Math/MathML"...
Rapid eye movement (REM) sleep behavior disorder (RBD) may be a risk factor for cognitive impairment in patients with Parkinson's disease (PD). However, little is known regarding the relation between severity of RBD and different domains impairment. The aim this study was: (1) to investigate PD RBD, (2) explore factors PD-mild (PD-MCI) relationship PD.The participants were grouped as follows: without (PD-RBD; n = 42), (PD + RBD; 32), idiopathic (iRBD; 15), healthy controls (HCs; 36). All...
Spin and lattice are two fundamental degrees of freedom in a solid, their fluctuations about the equilibrium values magnetic ordered crystalline form quasiparticles termed magnons (spin waves) phonons (lattice waves), respectively. In most materials with strong spin-lattice coupling (SLC), interaction spin induces energy gaps wave dispersion at nominal intersections magnon phonon modes. Here we use neutron scattering to show that two-dimensional (2D) van der Waals honeycomb ferromagnetic CrGeTe
Background Abnormal interhemispheric functional connectivity is frequently reported in Parkinson’s disease (PD), but its structural basis remains unclear. This study aimed to investigate changes functional, structural, and callosal connectivity, as well their interrelationships, PD patients. Methods The included 57 patients 50 healthy controls (HCs). Interhemispheric was evaluated using voxel mirrored homotopic (VMHC) derived from resting-state MRI, while measured through cortical thickness...
Background Chronic pain is a common non-motor symptom of Parkinson’s disease (PD) that significantly impacts patients’ quality life, but its neural mechanisms remain poorly understood. This study investigated changes in spontaneous neuronal activity and functional connectivity (FC) associated with chronic PD patients. Methods The included 41 patients (PDP), without (nPDP), 29 healthy controls. Pain severity was assessed using the visual analog scale (VAS). Resting-state fMRI images were used...
Urine is thought to provide earlier and more sensitive molecular changes for biomarker discovery than blood. Numerous glycoproteins, peptides, free glycans are present in urine through glomerular filtration of plasma, cell shedding, apoptosis, proteolytic cleavage, exosome secretion. biomarkers have enormous diagnostic potential, the use these a long-standing practice. The non-urological disease from also gaining attention due its non-invasive sample collection ease analysis. Abnormal...
Pathologic progression across the cortex is a key feature of Parkinson disease (PD). Cortical gyrification morphologic human cerebral that tightly linked to integrity underlying axonal connectivity. Monitoring cortical reductions may provide sensitive marker through structural connectivity, preceding progressive stages PD pathology. We aimed examine and their associations with overlying thickness, white matter (WM) integrity, striatum dopamine availability, serum neurofilament light (NfL)...
Background Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD), inducing and accelerating dopaminergic (DA) neuron loss. Autophagy, a critical mechanism for clearing misfolded or aggregated proteins such as α-synuclein (α-SYN), may affect DA survival midbrain. However, whether autophagy contributes to neuroinflammation-induced toxicity neurons remains unknown. Results Intraperitoneal injection lipopolysaccharide (LPS, 5 mg/kg) into young (3-month-old)...