A5102710154- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Parkinson's Disease Mechanisms and Treatments
- Flavonoids in Medical Research
- Autophagy in Disease and Therapy
- Otitis Media and Relapsing Polychondritis
- RNA regulation and disease
- Airway Management and Intubation Techniques
- Nerve injury and regeneration
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Milk Quality and Mastitis in Dairy Cows
- Neurological Disease Mechanisms and Treatments
Jiangsu University
2012-2025
Affiliated Hospital of Jiangsu University
2019-2025
Qilu Hospital of Shandong University
2013-2024
Affiliated Hospital of Hebei University
2023
Rice Research Institute
2023
Guangdong Academy of Agricultural Sciences
2023
Intensive Care Society
2023
Zhongkai University of Agriculture and Engineering
2023
Central People's Hospital of Zhanjiang
2013-2021
Northwest A&F University
2017-2019
Allergic rhinitis (AR) is an important risk factor for the development of asthma. The "unified airway" theory considers upper and lower airways as a morphological functional whole. However, studies exploring biomarkers linking in allergic disease are lacking, which may provide insight into mechanisms underlying AR comorbid asthma.To integrate bioinformatics techniques to explore airway diseases, molecular etiology profile preventing asthma patients.Biomarkers were screened by identifying key...
Background The intranasal endoscopic prelacrimal recess approach (PLRA) access to all aspects of the maxillary sinus while preserving inferior turbinate and nasolacrimal duct its use have been reported in treatment many lateral skull base diseases. Objective To retrospectively assess effectiveness a 10-year multicenter follow-up for resection inverted papilloma (IPMS) via PLRA. Methods A total 71 patients were admitted underwent IPMS excision an PLRA from 2003 2013. All high-resolution...
Parkinson's disease (PD) is a limb movement disorder caused by the degeneration of brain neurons and seriously affects quality life elderly. However, current drugs are symptomatic treatments that cannot prevent or delay development disease. Targeted therapy for pathogenesis may be direction in future. Oxidative stress inflammatory response involved PD. Edaravone scutellarin have been studied antioxidant anti-inflammatory reactions. The focus this study whether there synergy between two its...
Background Vitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives present study were to evaluate association between dietary vitamin intake cognitive function in elderly adults explore potential impact serum neurofilament light chain (NfL) concentration. Methods Data from 468 individuals, including information on consumption 10 vitamins, used. Cognitive performance was assessed according a composite Z-score Animal Fluency Test...
Seasonal allergic rhinitis (SAR) places a significant socioeconomic burden, particularly on individuals with poorly managed recurrent and severe symptoms despite standard-of-care treatment. Stapokibart, humanized monoclonal antibody that targets the interleukin (IL)-4 receptor subunit alpha, inhibits its interaction both IL-4 IL-13 in type 2 inflammation. Here we aim to assess efficacy safety of stapokibart as an add-on therapy adults moderate-to-severe SAR. The study was phase 3...
In order to investigate the mechanisms and therapeutic effects of valproate combined with lithium carbonate on mouse model Parkinson's disease (PD), male C57BL/6 mice were injected into intraperitoneal (20 μg/ml) (10 for 7 days following 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) (30 mg/kg) administration, motor function analyzed. Immunohistochemistry Western blotting used detect alterations in expression PD biomarkers, including tyrosine hydroxylase (TH), level autophagy was...
Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal pulmonary fibrosis. However, the role bovine mastitis mastitis-caused is still unclear. In our study, was characterized as a novel regulator EMT induced by transforming growth factor-β1 (TGF-β1) mammary alveolar cell-T (MAC-T) cell line. We found that highly expressed tissues MAC-T cells virulence factors...
We evaluated the diagnostic value of long non-coding RNA growth arrest-specific transcript 5 (GAS5) and its relationship with hippocampal volume in Alzheimer's disease (AD). One hundred eight patients AD 83 healthy controls were included, demographic data, biochemical parameters, GAS5 levels, recorded. Chi-squared tests or independent sample t-tests used to compare baseline characteristics, relative expression GAS5, volume. Correlations between variables determined using Spearman's rank...
Allergic rhinitis (AR) is one of the common disorders in airway allergic inflammation. The pathogenesis AR unclear. It accepted that immune deregulation associated with AR. Recent reports suggest a large number micro RNAs (miR) can regulate functions. This study aims to investigate role miR-146a an enforcing immunotherapy In this study, mouse model was created. levels nasal mucosa were assessed by real time RT-PCR. A specific performed mice. results showed mice had AR-like inflammation...
Patients with chronic rhinosinusitis nasal polyps (CRSwNP) and asthma comorbidity (ACRSwNP) present severe symptoms are more likely to relapse. However, the pathogenesis of ACRSwNP is not fully understood. The aim this study was explore underlying using bioinformatics approaches. ACRSwNP-related differentially expressed genes (DEGs) were identified by analysis GSE23552 dataset. clusterProfiler R package used carry out functional pathway enrichment analysis. A protein–protein interaction...
Chronic rhinosinusitis (CRS) is characterized by poor prognosis and propensity for recurrence even after surgery. Identification of those CRS patients with high risk relapse preoperatively will contribute to personalized treatment recommendations. In this paper, we proposed a multi-task deep learning network sinus segmentation prediction simultaneously develop validate radiomics-based nomogram predicting in who needed surgical treatment. 265 paranasal sinuses computed tomography (CT) images...
What is the central question of this study? mechanism DNA methylation in allergic rhinitis? main finding and its importance? A miR-199-3p-Dnmt3a-STAT3 signalling pathway involved ovalbumin-induced rhinitis, miR-199-3p antagomir can relieve symptoms mouse model.Recent research has pointed out involvement epigenetic modifications rhinitis (AR), especially methylation. However, detailed remained largely uncovered. We used ovalbumin (OVA) to induce AR mouse, behaviour scores were confirm...
Notch1 expression has been reported to be associated with chemotherapy resistance and poor prognosis, but the role of in head neck squamous cell carcinoma (HNSCC) sensitivity anticancer drugs remains unclear. The aim this study was evaluate HNSCC paclitaxel cisplatin vitro chemotherapeutic response these two vivo.We used immunohistochemistry assess fresh samples treated by PF (cisplatin+5- fluorouracil) TPF (paclitaxel + cisplatin+5- fluorouracil). We also assessed lines inhibitor...
Alzheimer's disease (AD) is an intractable and progressive neurodegenerative disorder that can lead to severe cognitive decline, impaired speech, short-term memory loss, finally inability function in daily life. For patients, their families, even all of society, AD impart great emotional pressure economic costs. Therefore, this study aimed investigate potential diagnostic biomarkers AD. Using the Gene Expression Omnibus (GEO) database, expression profiles genes were extracted from GSE5281,...
High-salinity and blast disease are two major stresses that cause dramatic yield loss in rice production. GF14 (14-3-3) genes have been reported to play important role biotic abiotic plants. However, the roles of OsGF14C remain unknown. To understand functions regulatory mechanisms regulating salinity tolerance resistance rice, we conducted OsGF14C-overexpressing transgenic experiments present study. Our results showed overexpression enhanced but reduced rice. The is related reduction...
This study compares clinical characteristics and survival between patients with without laryngeal function (LF) preservation during surgical treatment for hypopharyngeal carcinoma. We retrospectively reviewed 485 cases of carcinoma treated at a single institution analysis. There were 337 148 LF after surgery. Preservation was complete in 237 partial 100 patients. significant statistical differences the group T-stage (P < 0.001), overall staging tumor sites 0.001) except N-stage = 0.240). The...
ABSTRACT Purpose To explore the diagnostic value of serum apolipoprotein B100 (Apo B100) combined with hippocampal volume in Alzheimer's disease (AD). Methods A total 59 AD patients and healthy subjects were selected. The Mini‐Mental State Examination (MMSE) was used for neuropsychological assessment. Blood glucose lipid levels detected by biochemical analyzer. Polymerase chain reaction (PCR) to detect E E) ε3/ε4 genotypes plasma. Hippocampal calculated using Slicer software....
Hundreds of miRNAs have been reported to be dysregulated in Parkinson's disease (PD), providing valuable assistance improving its diagnosis. The purpose this study was analyze the expression and diagnostic value miR-19b-3p PD patients, as well relationship with inflammatory factors.