A5100359539- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Silymarin and Mushroom Poisoning
- Biosensors and Analytical Detection
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 detection and testing
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Molecular Biology Techniques and Applications
Tianjin University of Science and Technology
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022-2025
Shanghai University of Traditional Chinese Medicine
2021-2025
Southern Medical University
2021-2025
The First People's Hospital of Shunde
2024-2025
State Key Laboratory of Digital Medical Engineering
2019-2024
Second Affiliated Hospital of Zhejiang University
2016-2024
Chinese Academy of Agricultural Sciences
2019-2024
Cangzhou Central Hospital
2013-2024
Chengdu University of Traditional Chinese Medicine
2024
Abstract Since the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2), public health worldwide has been greatly threatened. The development an effective treatment for this infection is crucial and urgent but hampered incomplete understanding viral mechanism lack specific antiviral agents. We previously reported that teicoplanin, a glycopeptide antibiotic commonly used in clinic to treat bacterial infection, significantly restrained cell...
Although inhibition of SGK1 has been shown to delay cancer progression, the underlying mechanisms have not yet elucidated. We investigated cellular responses GSK650394 treatment and silencing (or overexpression) in human prostate (PCa) cell lines PC3 xenografts by flow cytometry, western blotting, immunofluorescence, transmission electron microscopy immunohistochemistry. In present study, we demonstrated that inhibition, mediated either or shRNA, induced G2/M arrest, apoptosis autophagy....
Cardiac stem cells (CSCs) have emerged as one of the most promising for cardiac protection. Recently, exosomes from bone marrow-derived mesenchymal (BMSCs) been found to facilitate cell proliferation and survival by transporting various bioactive molecules, including microRNAs (miRs). In this study, we that BMSC-derived (BMSC-exos) significantly decreased apoptosis rates reactive oxygen species (ROS) production in CSCs after oxidative stress injury. Moreover, a stronger effect was induced...
Studies show that high expression of non-SMC condensin I complex subunit G (NCAPG) is associated with many tumors. In this study, we explore the mechanism by which NCAPG promotes proliferation in hepatocellular carcinoma (HCC). Liver cancer and paracancerous tissue specimens 90 HCC patients were collected, levels these tissues cell lines evaluated Western blotting immunohistochemistry. cells transfected siRNAs plasmids, pathway activators or inhibitors added. The 5-ethynyl-2'-deoxyuridine...
Herein, by directly limiting the reaction space, an ingenious three-dimensional (3D) DNA walker (IDW) with high walking efficiency is developed for rapid and sensitive detection of miRNA. Compared traditional walker, IDW immobilized tetrahedral nanostructure (DTN) brings stronger kinetic thermodynamic favorability resulting from its improved local concentration space confinement effect, accompanied a quite faster speed much better efficiency. Once traces target miRNA-21 react prelocked IDW,...
M2 macrophage-mediated tissue repair plays an important role in acute myocardial infarction (AMI).Additionally, VSIG4, which is mainly expressed on tissue-resident and macrophages, crucial for the regulation of immune homeostasis; however, its effects AMI remain unknown.In this study, we aimed to investigate functional significance VSIG4 using knockout adoptive bone marrow transfer chimeric models.We also determined function cardiac fibroblasts (CFs) through gain-or loss-of-function...
The profiling of multiple glycans on a single cell is important for elucidating glycosylation mechanisms and accurately identifying disease states. Herein, we developed closed bipolar electrode (BPE) array chip live single-cell trapping in situ galactose sialic acid detection with the electrochemiluminescence (ECL) method. Methylene blue-DNA (MB-DNA) as well biotin-DNA (Bio-DNA) codecorated AuNPs were prepared nanoprobes, which selectively labeled surface through chemoselective labeling...
S100 family genes encode low molecular weight, acidic-Ca2+ binding proteins implicating in a wide spectrum of biological processes. contains at least 20 members, most which are frequently dysregulated human malignancies including breast cancer. However, the prognostic roles each individual S100, especially mRNA level, cancer patients remain elusive. In current study, we used "The Kaplan-Meier plotter" (KM plotter) database to investigate values expression Our results indicated that high...
Despite SGK1 has been identified and characterized as a tumor-promoting gene, the functions underlying mechanisms of involved in metastasis regulation have not yet investigated cancer. We cellular responses to GSK650394 treatment silencing (or overexpression) human prostate cancer (PCa) cell lines PC3 xenografts by wound healing assay, migration invasion western blotting, immunofluorescence immunohistochemistry. In present study, we found that expression positively correlates with...
Significance Although many efforts have been devoted to localize and monitor cancer progression, it is still difficult precisely evaluate the development of cancers for efficient targeted treatments. Herein, we demonstrate a straightforward strategy using in situ self-assembly gold nanocluster–DNA complexes. In combination with tumor suppressor gene-phosphatase tensin homolog (PTEN), nanocluster-PTEN complexes could realize bioimaging identification simultaneously inhibit effect relevant...
Lactate has emerged as a key player in regulating neural functions and cognitive processes. Beyond its function an energy substrate signal molecule, recent research revealed lactate to serve epigenetic regulator the brain. However, molecular mechanisms by which regulates spatial memory role prevention of disorders remain unclear. Herein, we injected L-lactate (10 μmol/kg/d for 6 d) into mouse’s hippocampus, followed Morris water maze (MWM) test analyses. Improved performances were observed...
Background. Diabetes is a major risk factor for the development of kidney disease. We aimed to determine prevalence albuminuria and chronic disease (CKD) in Chinese subjects with diabetes pre-diabetes factors
The estrogen receptor alpha (ERα) has been proven to be one of the most important therapeutic targets in breast cancer over last 30 years. Previous studies pointed out that a natural flavonoid, silibinin, induced apoptosis human MCF-7 cells. In present study we report exposure cells silibinin led cell death through down-regulation ERα expression. Silibinin-induced up-regulation caspase 6 due signalling repression was further boosted by antagonist. Moreover, autophagy accounted for apoptotic...
Increasing evidence has suggested that long noncoding RNAs (lncRNAs) play critical roles in cancer development. Nasopharyngeal carcinoma (NPC) is a disease with high incidence. Although remarkable progress been made understanding the molecular mechanism and therapy strategies NPC, potential involvement of lncRNAs NPC remains largely unknown. In this study, we identified lncRNA susceptibility candidate 9 (CASC9) highly expressed tissues, which facilitates cell growth correlated poor prognosis...
Abstract Sirt1 is an NAD + ‐dependent deacetylase that protects against premature aging and cell senescence. Aging accompanied by oxidative stress leads to a decrease in levels activity, but the regulatory mechanism connects these events remains unclear. Here, we reported Nur77, which shares similar biological pathways with Sirt1, was also decreased age multiple organs. Our vivo vitro results revealed Nur77 during stress‐induced Deletion of Nr4a1 shortened lifespan accelerated process mouse...