A5101760866- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Healthcare Systems and Reforms
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Global Health Care Issues
- Autophagy in Disease and Therapy
- Healthcare Policy and Management
- Skin Protection and Aging
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Synthesis and biological activity
- Air Quality Monitoring and Forecasting
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Indoor Air Quality and Microbial Exposure
- Cancer-related Molecular Pathways
- Health, Environment, Cognitive Aging
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
Wuhan University
2017-2025
China Three Gorges Corporation (China)
2022-2025
Northwest A&F University
2021-2024
Ministry of Ecology and Environment
2024
Xuzhou Medical College
2016-2024
Second People’s Hospital of Huai’an
2016-2024
Huazhong University of Science and Technology
2012-2024
Fudan University
2022-2024
Anhui University of Traditional Chinese Medicine
2024
Army Medical University
2013-2023
Abstract Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Disease 2019 (COVID-19) and crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying SARS-CoV-2-induced cytokine critical for control. Here, we identify that SARS-CoV-2 ORF3a host hypoxia-inducible factor-1α (HIF-1α) play key roles virus infection pro-inflammatory responses. RNA sequencing shows HIF-1α signaling, immune response,...
Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical and related risks. For this study, we collected serum samples from 5696 healthy people patients, including those with 12 in China completed biomonitoring 267 chemicals via gas liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected were used for exposure characterization risk analysis. The results show...
Although inhibition of SGK1 has been shown to delay cancer progression, the underlying mechanisms have not yet elucidated. We investigated cellular responses GSK650394 treatment and silencing (or overexpression) in human prostate (PCa) cell lines PC3 xenografts by flow cytometry, western blotting, immunofluorescence, transmission electron microscopy immunohistochemistry. In present study, we demonstrated that inhibition, mediated either or shRNA, induced G2/M arrest, apoptosis autophagy....
BACKGROUND Although SDF-1/CXCR4 pathway is a potential mechanism of tumor proliferation and progression, the controlling CXCR4 expression not fully understood. This study was to confirm that miR-494-3p might be potentially post-transcriptional regulator over-expression miR-494 suppress prostate cancer progression metastasis. MATERIALS AND METHODS We firstly postulated regulation by through bioinformatics analysis, then it demonstrated could regulate mRNA post-transcriptionally binding...
Introduction Osteoporosis, a disease of reduced bone mass and microstructural deterioration leading to fragility fractures, is becoming more prevalent as aging progresses, significantly increasing the socioeconomic burden. In past studies, there has been growing awareness harmful effects heavy metals on bone, with cadmium being significant exposure factor. The purpose this study was look into association between adult mineral density(BMD) blood levels. Methods Based information from...
Abstract Background Since 2020, China has implemented an innovative payment method called Diagnosis-Intervention Packet (DIP) in 71 cities nationwide. This study aims to assess the impact of DIP on medical expenditure, efficiency, and quality for inpatients covered by Urban Employee Basic Medical Insurance (UEBMI) Rural Residents (URRBMI). It seeks explore whether there are differences these effects among two insurance types, thereby further understanding its implications health equity....
Health care workers are at the frontline in fight against infectious disease, and as a result high risk of infection. During 2014-2015 Ebola outbreak West Africa, many health contracted Ebola, some fatally. However, no members Chinese Anti-Ebola medical team, deployed to provide vital Liberia were infected. This study aims understand how this zero infection rate was achieved.Data collected through 15 in-depth interviews with participants from People's Liberation Army China team which...
Despite the clinical benefits of androgen deprivation therapy, most patients with advanced androgen-dependent prostate cancer (ADPC) eventually relapse and progress to lethal androgen-independent (AIPC), also termed castration-resistant (CRPC). MiRNAs can be packaged into exosomes (Exos) shuttled between cells. However, roles mechanisms exosomal miRNAs involved in CRPC progression have not yet been fully elucidated. Here, we find that miR-222-3p is elevated AIPC cells, which results...
Abstract Aims/Introduction The present study aimed to determine the associations between expressions of insulin‐like growth factor‐1 ( IGF ‐1), tumor necrosis factor‐α TNF ‐α) and vascular endothelial factor 165 VEGF ) in serum, occurrence development type 2 diabetic nephropathy DN ). Materials Methods A total 108 patients diagnosed as were randomly selected, including 50 microalbuminuria group, 44 macroalbuminuria group 14 renal insufficiency group. Meanwhile, 97 healthy people collected a...
MicroRNAs (miRNAs) are pivotal regulators of the progression carcinogenesis and negatively regulate expression tumour‑associated genes. Downregulation miR‑124 has been demonstrated in various human cancer tissues, wherein serves as a tumour suppressor by targeting oncogenes. However, its function underlying mechanism action remain unclear breast cancer. In present study, tissue‑specific was detected 10 paired triple‑negative normal inhibitory effects on cell growth invasion were evaluated...
Breast cancer (BC) is one of the most common malignant tumours in women. The matrix metalloproteinase (MMP) enzyme family plays a complex role development BC. There increasing evidence that MMP11 major BC; however, underlying mechanisms are not clear. present study confirmed by analysing clinical samples and TCGA data sets, high expression BC was strongly associated with poor prognosis patients. In addition, MTT colony formation assays indicated proliferative capacity affected when changed....
Abstract Background The widespread pandemic of novel coronavirus disease 2019 (COVID-19) poses an unprecedented global health crisis. In the United States (US), different state governments have adopted various combinations non-pharmaceutical public interventions (NPIs), such as non-essential business closures and gathering bans, to mitigate epidemic from February April, 2020. Quantitative assessment on effectiveness NPIs is greatly needed assist in guiding individualized decision making for...
Members of the R2R3-MYB transcription factor superfamily have been implicated in plant development, improved disease resistance, and defense responses to several types stresses. To study function TaMYB29 factor-a member superfamily-in response an avirulent race stripe rust pathogen, Puccinia striiformis f. sp. tritici (Pst), we identified cloned gene from wheat cultivar (cv.) AvS+Yr10 following infection with Pst. The protein, comprising 261 amino acids, contains two highly conserved MYB...
Acute kidney injury (AKI), mainly caused by Ischemia/reperfusion (IRI), is a common and severe life-threatening disease with high mortality. Accumulating evidence suggested direct relationship between endoplasmic reticulum (ER) stress response AKI progression. However, the role of transmissible ER response, new modulator cell-to-cell communication, in influencing intercellular communication renal tubular epithelial cells (TECs) macrophages microenvironment remains to be determined. To...
The severe health challenge and financial burden of drug-resistant tuberculosis (DR-TB) continues to be an impediment in China worldwide. This study aimed explore the impact Diagnosis-related group (DRG) payment on medical expenditure treatment efficiency among DR-TB patients. retrospective cohort included all patients from digitized Hospital Information System (HIS) Wuhan Pulmonary TB Management (TBIMS) with completed full course National Tuberculosis Program (NTP) standard January 2016...