A5035285684- Inflammasome and immune disorders
- interferon and immune responses
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Soft Robotics and Applications
- Robot Manipulation and Learning
- Advanced Sensor and Control Systems
- COVID-19 Clinical Research Studies
- Advanced Algorithms and Applications
- Fault Detection and Control Systems
- Nonlinear Optical Materials Research
- Nonlinear Optical Materials Studies
- Prosthetics and Rehabilitation Robotics
- Optical measurement and interference techniques
- Phagocytosis and Immune Regulation
- Advanced Measurement and Metrology Techniques
- Malaria Research and Control
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Mine drainage and remediation techniques
- Electrocatalysts for Energy Conversion
- Plant Water Relations and Carbon Dynamics
- Elasticity and Material Modeling
- Pharmaceutical and Antibiotic Environmental Impacts
- Ubiquitin and proteasome pathways
Wuhan University
2011-2025
Dalian Maritime University
2014-2025
Guangdong Provincial People's Hospital
2021-2025
Guangdong Academy of Medical Sciences
2021-2025
Southern Medical University
2023-2025
Jiangnan University
2024-2025
Zhejiang University of Technology
2017-2024
Rice University
2024
Colorado State University
2024
Lanzhou University
2022-2024
Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to also COVID-19 severity. Here, we show a distinct mechanism by which N protein promotes NLRP3 inflammasome activation induce hyperinflammation. facilitates maturation proinflammatory cytokines and induces cultured cells mice. Mechanistically, interacts directly protein, the binding ASC, assembly. More importantly, aggravates lung...
Zika virus (ZIKV) infection is a public health emergency and host innate immunity essential for the control of infection. The NLRP3 inflammasome plays key role in immune responses by activating caspase-1 to facilitate interleukin-1β (IL-1β) secretion. Here we report that ZIKV stimulates IL-1β secretion infected patients, human PBMCs macrophages, mice, mice BMDCs. knockdown cells knockout inhibit ZIKV-mediated secretion, indicating an ZIKV-induced activation. Moreover, NS5 protein required...
Abstract Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Disease 2019 (COVID-19) and crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying SARS-CoV-2-induced cytokine critical for control. Here, we identify that SARS-CoV-2 ORF3a host hypoxia-inducible factor-1α (HIF-1α) play key roles virus infection pro-inflammatory responses. RNA sequencing shows HIF-1α signaling, immune response,...
One of the fundamental reactions innate immune responses to pathogen infection is release pro-inflammatory cytokines, including IL-1β, processed by NLRP3 inflammasome. The stimulator interferon genes (STING) has essential roles in response against infections. Here we reveal a distinct mechanism which STING regulates inflammasome activation, IL-1β secretion, and inflammatory human cell lines, mice primary cells, mice. Interestingly, upon HSV-1 cytosolic DNA stimulation, binds promotes...
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows disturbed type I interferon (IFN) response during the virus infection. In this study, we discovered that nucleocapsid (N) protein of plays an important role inhibition beta (IFN-β) production. N repressed IFN-β production induced by poly(I:C) or upon Sendai (SeV) We noted also suppressed production, several signaling molecules downstream retinoic acid-inducible gene (RIG-I)...
Here, we present a platelet-facilitated photothermal tumor therapy (PLT-PTT) strategy, in which PLTs act as carriers for targeted delivery of agents to tissues and enhance the PTT effect. Gold nanorods (AuNRs) were first loaded into by electroporation resulting AuNR-loaded (PLT-AuNRs) inherited long blood circulation cancer targeting characteristics from good property AuNRs. Using gene-knockout mouse model, demonstrate that administration PLT-AuNRs localizing laser irradiation could...
Activation of NLRP3 inflammasome is important for effective host defense against invading pathogen. Together with apoptosis-associated speck-like protein containing CARD domain (ASC), induces the cleavage caspase-1 to facilitate maturation interleukin-1beta (IL-1β), an pro-inflammatory cytokine. IL-1β subsequently plays critical roles in inflammatory responses by activating immune cells and inducing many secondary cytokines. Although role response well defined, mechanism underlying its...
As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor 7 (TLR7) acts as an innate immune is also death the central nervous system (CNS). However, mechanisms underlying regulation of TLR7-mediated brain pathogenesis upon EV71 remain largely elusive. Here we reveal novel mechanism by which infects astrocytes induces neural via TLR7 interleukin-6 (IL-6) C57BL/6 mice...
COVID-19 is infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can cause multiple organ injury death. Kidney one of major target organs kidney (AKI) common in critically ill patients. However, mechanisms through which causes AKI remain largely unknown treatment remains unspecific ineffective. Here, the authors report that normal kidney-specifically overexpressing SARS-CoV-2 N develops AKI, worsens mice under ischemic condition. Mechanistically, it uncovered...
NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection. The RAF-MEK1/2-ERK1/2 cascade downstream c-Jun/Fos Activator protein-1 (AP1) signaling pathway control the degree of response. Influenza A virus (IAV) infection is known stimulate activation responses. Nevertheless, detailed mechanism by which IAV induces involved in transcription pro-IL-1β...
Abstract Viral infection in respiratory tract usually leads to cell death, impairing function cause severe disease. However, the diversity of clinical manifestations SARS-CoV-2 increases complexity and difficulty viral prevention, especially high-frequency asymptomatic risk virus transmission. Studying how affects apoptotic pathway may help understand pathological process its infection. Here, we uncovered imployed a distinct anti-apoptotic mechanism via N protein. We found virus-like...
Aberrant activity of NLRP3 has been shown associations with severe diseases. Palmitoylation is a kind protein post-translational modification, which to regulate cancer development and the innate immune system. Here, we showed that palmitoylated at Cys419 palmitoyltransferase ZDHHC17 predominant enzyme mediates palmitoylation promotes activation by interacting facilitating NIMA-related kinase 7 (NEK7)-NLRP3 interactions. Blockade inhibitor, 2-bromopalmitate, effectively inhibited in vitro....
Pyroptosis, a gasdermin-mediated immunogenic cell death, has been shown to elicit adaptive antitumor immune responses, thereby augmenting the response cancer immunotherapy when pyroptosis is therapeutically activated. However, despite increased gasdermin E (GSDME) expression, significant remains elusive in certain tumor types, and underlying regulatory mechanisms are poorly understood. In this study, we observed high signal protein α1 (SIRPA) expression head neck squamous carcinoma (HNSCC)...
Zika virus (ZIKV) has emerged as a global health threat due to its unexpected causal link devastating neurological disorders such fetal microcephaly; however, date, no approved vaccine or specific treatment is available for ZIKV infection. Here we develop biomimetic nanodecoy (ND) that can trap ZIKV, divert away from intended targets, and inhibit The ND, which composed of gelatin nanoparticle core camouflaged by mosquito medium host cell membranes, effectively adsorbs inhibits replication in...
Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), even fatal neurological complications. However, the mechanisms underlying EV71 pathogeneses are largely unknown. This study reveals a distinct mechanism by which induces apoptosis autophagy in neural cells. non-structure protein 3D (also known as RNA-dependent RNA polymerase, RdRp) interacts with peroxisomal acyl-CoA oxidase 1 (ACOX1), contributes to ACOX1 downregulation. Further studies demonstrate that reduces...
Activation of the NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome plays a key role in host immune response, which is first line defense against cellular stresses pathogen infections. However, excessive activation damages cells, therefore it must be precisely controlled. Here, we discover that Cullin1 (CUL1), component Skp1-Cullin1-F-box E3 ligase, critical controlling NLRP3 inflammasome. CUL1 represses assembly cultured suppresses...
The immune system is not only required for preventing threats exerted by pathogens but also essential developing tolerance to avoid tissue damage. This study identifies a distinct mechanism which MYSM1 suppresses innate immunity and autoimmunity. expression of induced upon DNA virus infection intracellular stimulation. subsequently interacts with STING cleaves K63-linked ubiquitination suppress cGAS-STING signaling. Notably, Mysm1-deficient mice exhibit hyper-inflammatory response, acute...
Dengue virus (DENV) infection causes serious clinical symptoms, including dengue hemorrhagic fever (DHF) and shock syndrome (DSS). Vascular permeability change is the main feature of diseases, abnormal expression proinflammatory cytokines important cause vascular change. However, mechanism underlying induced by DENV has not been fully elucidated. Here, we reveal a distinct which promotes NLRP3 inflammasome activation interleukin-1 beta (IL-1β) release to induce endothelial leakage in mice. M...
Abstract Background Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets. ATP directly activates plasma membrane channel P2X7 receptor (P2X7R), leading an intracellular influx of K + , trigger inducing NLRP3 inflammasome activation. However, mechanism underlying P2X7R-mediated activation poorly understood,...
Dengue virus (DENV) is a mosquito-borne pathogen that causes spectrum of diseases including life-threatening dengue hemorrhagic fever (DHF) and shock syndrome (DSS). Vascular leakage common clinical crisis in DHF/DSS patients highly associated with increased endothelial permeability. The presence vascular hypotension, circulatory failure, disseminated intravascular coagulation as the disease progresses patients, which can lead to death patients. However, mechanisms by DENV infection caused...
Abstract The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting caspase1‐dependent induction of pro‐inflammatory cytokines. However, aberrant activation causes diverse diseases, thus activity must be tightly controlled. Here, we reveal a molecular mechanism underlying the regulation inflammasome. interacts with SUMO‐conjugating enzyme (UBC9), which subsequently promotes small ubiquitin‐like modifier 1 (SUMO1) to catalyze SUMOylation at residue Lys 204 ....