COVID-19 is infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can cause multiple organ injury death. Kidney one of major target organs kidney (AKI) common in critically ill patients. However, mechanisms through which causes AKI remain largely unknown treatment remains unspecific ineffective. Here, the authors report that normal kidney-specifically overexpressing SARS-CoV-2 N develops AKI, worsens mice under ischemic condition. Mechanistically, it uncovered...

Clopidogrel, a P2Y12 inhibitor, is novel anti-fibrosis agent for chronic kidney disease (CKD), but its mechanisms remain unclear, which we investigated by silencing or treating unilateral ureteral obstruction (UUO) in LysM-Cre/Rosa Tomato mice with clopidogrel vivo and vitro. We found that was significantly increased correlated progressive renal fibrosis CKD patients UUO mice. Phenotypically, up to 82% of P2Y12-expressing cells within the fibrosing were macrophage origin, identified...

As social media platforms are evolving from text-based forums into multi-modal environments, the nature of misinformation in is also transforming accordingly. Misinformation spreaders have recently targeted contextual connections between modalities e.g., text and image. However, existing datasets for rumor detection mainly focus on a single modality i.e., text. To bridge this gap, we construct MR2, multimodal multilingual retrieval-augmented dataset detection. The covers rumors with images...

CRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role remains unclear. Thus we sought to investigate the of AKI. Clinically, elevated serum levels were found associate closely with increased creatinine and urea (P<0.01) patients AKI, which then fell after recovery from To determine ischaemia/reperfusion mouse model was developed using Tg (transgenic) mice that express human CRP. Compared WT (wild-type) mice, more severe renal...

Acute kidney injury (AKI) is a severe complication associated with abdominal aortic aneurysm (AAA) repair. In this study, we evaluated the incidence, risk factors and in-hospital mortality of AKI in patients after AAA repair surgery.A total 314 Chinese who underwent endovascular (EVAR) or open (OPEN) were enrolled study. was diagnosed according to 2012 KDIGO criteria. Logistic regression modeling used explore AKI, while investigated using Cox proportional hazards model Kaplan-Meier analysis,...

Abstract Background Emerging evidence has demonstrated that acute kidney injury (AKI) is an important risk factor associated with increased morbidity and mortality in diabetic ketoacidosis (DKA) patients. The current study aimed to investigate the incidence rate, factors, long-term renal outcomes, DKA patients AKI. Methods A total of 179 diagnosed at Sun Yat-sen Memorial Hospital from January 2012 2018 were included analysis. AKI was according KDIGO criteria. Risk analyzed by logistic...

Abstract Exosomes have been shown to effectively regulate the biological functions of target cells. Here, we investigated protective effect and mechanism hypoxia-induced renal tubular epithelial cells (TECs)-derived exosomes on acute injury. We found that in vitro (Hy-EXOs) were injury by promoting TECs proliferation improving mitochondrial functions. By using exosome miRNA sequencing, identified miR-20a-5p was abundant a key for Hy-EXOs as up-regulation enhanced but down-regulation...

Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are common in patients with chronic kidney disease (CKD), but uniform thresholds derived from the general population may not accurately predict heart failure (HF) risk across stages of function. This study aimed to determine whether specific function categories improve HF prediction CKD. retrospective cohort used data China Renal Data System, including 18 261 CKD without prior HF. Kidney function-specific for NT-proBNP...

Recent studies show that C-reactive protein (CRP) is not only a biomarker but also pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels CRP in healthy ageing population remained unclear, which was investigated present study. Serum high sensitive (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein (HDL-c), low-density (LDL-c), superoxide dismutase (SOD), creatinine (SCr), uric acid (SUA)...

Plasma levels of neuropeptide Y (NPY) are elevated in patients with acute myocardial infarction (AMI), but its role AMI remains unclear, which was examined here NPY wild-type/knockout (WT/KO) mice treated with/without exogenous and Y1 receptor antagonist (Y1Ra) BIBP 3226. We found that lacking developed more severe than WT worse cardiac dysfunction, progressive inflammation fibrosis, excessive apoptosis impairing angiogenesis. All these changes were reversed when the KO a dose-dependent...

Increasing evidence shows that SARS-CoV-2 can infect kidneys and cause acute kidney injury (AKI) in critically ill COVID-19 patients. However, mechanisms through which induces AKI are largely unknown, treatment remains ineffective. Here, we report kidney-specific overexpressing N gene AKI, including tubular necrosis elevated levels of serum creatinine BUN 8-week-old diabetic db/db mice, become worse those with older age (16 weeks) underlying disease (DKD). Treatment quercetin, a purified...

Many patients with systemic lupus erythematosus (SLE) have nephritis, one of the severe complications SLE. We previously reported that CD8+CD103+ T regulatory cells induced ex vivo transforming growth factor β (TGF-β) (iTregs) inhibited immune responses to ameliorate excessive autoimmune inflammation. However, molecular mechanism(s) underlying role these CD8+ iTregs is still unclear. Here we identified CD39, which highly expressed on iTregs, crucially contributes immunosuppressive iTregs....

Aims: The effect of the angiotensin receptor–neprilysin inhibitor (ARNI) sacubitril-valsartan in patients with heart failure preserved ejection fraction (HFpEF) remains unclear, and data on ARNI treatment peritoneal dialysis (PD) are lacking. present study was designed to assess efficacy safety HFpEF undergoing dialysis. Methods Results: End-stage kidney disease (ESKD) PD for 3 months New York Heart Association (NYHA) class II–IV failure, 50% or higher, elevated levels N-terminal pro–B-type...

Transforming growth factor β (TGF-β)/Smad3 signaling plays a central role in chronic heart disease. Here, we report that targeting Smad3 with inhibitor SIS3 an established mouse model of hypertension significantly improved cardiac dysfunctions by preserving the left ventricle (LV) ejection fraction (LVEF) and LV fractional shortening (LVFS), while reducing mass. In addition, treatment also halted progression myocardial fibrosis blocking α-smooth muscle actin-positive (α-SMA+) myofibroblasts...

How can we better extract entities and relations from text? Using multimodal extraction with images text obtains more signals for relations, aligns them through graphs or hierarchical fusion, aiding in extraction. Despite attempts at various fusions, previous works have overlooked many unlabeled image-caption pairs, such as NewsCLIPing. This paper proposes innovative pre-training objectives entity-object relation-image alignment, extracting objects aligning entity relation prompts soft...

“Cytokine storm” is common in critically ill COVID-19 patients, however, mechanisms remain largely unknown. Here, we reported that overexpression of SARS-CoV-2 N protein diabetic db/db mice significantly increased tubular death and the release HMGB1, one damage-associated molecular patterns (DAMPs), to trigger M1 proinflammatory macrophage activation production IL-6, TNF-α, MCP-1 via a Mincle-Syk/NF-κB-dependent mechanism. This was further confirmed vitro caused HMGB1 from injured cells...

Cardiorenal syndrome highlights the bidirectional relationship between kidney and heart dysfunction. N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is gold standard biomarker in failure (HF), may be an important for chronic disease (CKD) progression. However, NT-proBNP negatively related with estimated glomerular filtration rate (eGFR). In this study, we investigated association of NT-proBNP, eGFR, progression CKD patients without HF.

Low-resource relation extraction (LRE) aims to extract potential relations from limited labeled corpus handle the problem of scarcity human annotations. Previous works mainly consist two categories methods: (1) Self-training methods, which improve themselves through models' predictions, thus suffering confirmation bias when predictions are wrong. (2) Self-ensembling learn task-agnostic representations, therefore, generally do not work well for specific tasks. In our work, we propose a novel...