A5034669107- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Genetic diversity and population structure
- Microbial Community Ecology and Physiology
- Parasite Biology and Host Interactions
- Marine Biology and Ecology Research
- Bacteriophages and microbial interactions
- Fish Ecology and Management Studies
- Environmental DNA in Biodiversity Studies
- Ichthyology and Marine Biology
- Marine Bivalve and Aquaculture Studies
- Protist diversity and phylogeny
- Renal Diseases and Glomerulopathies
- Salmonella and Campylobacter epidemiology
- Gallbladder and Bile Duct Disorders
- Erythrocyte Function and Pathophysiology
- Ocean Acidification Effects and Responses
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Abdominal Trauma and Injuries
- Diabetes and associated disorders
- Neurological and metabolic disorders
- Polymer Surface Interaction Studies
- Aquaculture disease management and microbiota
- Medical Research and Treatments
Institute of Hydrobiology
2011-2025
Chinese Academy of Sciences
2011-2025
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2023-2024
Sun Yat-sen Memorial Hospital
2014-2024
Sun Yat-sen University
2014-2024
Zigong First People's Hospital
2024
Nanchang University
2024
First Affiliated Hospital of Nanchang University
2024
Northwestern Polytechnical University
2023
Institute of Deep-Sea Science and Engineering
2023
Abstract It is largely unknown how living organisms—especially vertebrates—survive and thrive in the coldness, darkness high pressures of hadal zone. Here, we describe unique morphology genome Pseudoliparis swirei —a recently described snailfish species below a depth 6,000 m Mariana Trench. Unlike closely related shallow sea species, P. has transparent, unpigmented skin scales, thin incompletely ossified bones, an inflated stomach non-closed skull. Phylogenetic analyses show that diverged...
Environmental DNA (eDNA) originates from cellular material shed by organisms into aquatic or terrestrial environments and can be sampled monitored using metabarcoding technology, which is revolutionizing fish biodiversity monitoring. Several reviews concerning eDNA have focused on standard sampling methods its applications, though a systematic review marker genes, databases, bioinformatic pipelines has not yet been published. Here, we present comprehensive literature of studies applying...
Abstract Background Emerging evidence has demonstrated that acute kidney injury (AKI) is an important risk factor associated with increased morbidity and mortality in diabetic ketoacidosis (DKA) patients. The current study aimed to investigate the incidence rate, factors, long-term renal outcomes, DKA patients AKI. Methods A total of 179 diagnosed at Sun Yat-sen Memorial Hospital from January 2012 2018 were included analysis. AKI was according KDIGO criteria. Risk analyzed by logistic...
Abstract Exosomes have been shown to effectively regulate the biological functions of target cells. Here, we investigated protective effect and mechanism hypoxia-induced renal tubular epithelial cells (TECs)-derived exosomes on acute injury. We found that in vitro (Hy-EXOs) were injury by promoting TECs proliferation improving mitochondrial functions. By using exosome miRNA sequencing, identified miR-20a-5p was abundant a key for Hy-EXOs as up-regulation enhanced but down-regulation...
Background This study comprehensively investigates the association between expression of nicotinamide N-methyltransferase (NNMT) and clinical outcomes urothelial bladder cancer (UBC), as well molecular mechanisms by which NNMT in cancer-associated fibroblast (CAF) modulates tumor progression immunotherapy resistance UBC. Methods Single-cell transcriptomic analyses, immunohistochemical immunofluorescence assays were performed on samples to validate relationship outcomes. A series experiments,...
Erythropoietin-induced pure red blood cell aplastic anemia (EPO-PRCA) is a rare anemia，which presents significant treatment challenge, often necessitating the cessation of erythropoiesis-stimulating agents (ESAs) and adoption immunosuppressive therapies or renal transplantation. In present case, patient developed severe after 2-year EPO was diagnosed with EPO-PRCA. The full dose corticosteroids testosterone for one month failed to increase his hemoglobin (Hb) level significantly. Therefore,...
Abstract: The Liangzi Lake, a typical shallow lake in the middle reaches of Yangtze River, is important for water resource and biodiversity conservation. With development urbanization, anthropogenic activities have posed serious threats to quality Lake. To assess aquatic ecosystem health structure, environmental response, interactions plankton were investigated 2022 2023. Results indicated that temperature was pivotal factor regulating dynamics, while assemblage patterns predominantly shaped...
Liangzi Lake, a typical shallow lake in the middle reaches of Yangtze River, is important for water resource and biodiversity conservation. With development urbanization, anthropogenic activities have posed serious threats to quality Lake. To assess aquatic ecosystem health structure, environmental response, interactions plankton were investigated 2022 2023. The results indicated that temperature was pivotal factor regulating dynamics, with assemblage patterns predominantly shaped by...
The ciliated protozoan Tetrahymena thermophila is a useful unicellular model organism for studies of eukaryotic cellular and molecular biology. Researches on T. have contributed to series remarkable basic biological principles. After the macronuclear genome was sequenced, substantial progress has been made in functional genomics research thermophila, including genome-wide microarray analysis life cycle, gene network based data transcriptome by deep RNA sequencing. To meet growing demands...
Tetrahymena thermophila is a model eukaryotic organism. Functional genomic analyses in present rich opportunities to address fundamental questions of cell and molecular biology. The Gene Expression Database (TGED; available at http://tged.ihb.ac.cn) the first expression database ciliated protozoan. It covers three major physiological developmental states: growth, starvation, conjugation, can be accessed through user-friendly web interface. gene profiles candidate co-expressed genes for each...
Abstract The edible silver carp ( Hypophthalmichthys molitrix ) and bighead H. nobilis ), which are two of the “Four Domesticated Fish” China, cultivated intensively worldwide. Here, we constructed 837‐ 845‐Mb draft genome assemblies for carp, respectively, including 24,571 24,229 annotated protein‐coding genes. Genetic maps, anchoring 71.7% 83.8% all scaffolds, were obtained respectively. Phylogenetic analysis showed that formed a clade with an estimated divergence time 3.6 million years...
Apparent cases of sympatric speciation may actually be due to micro-allopatric or micro-parapatric speciation. One way distinguish between these models is examine the existence and nature genomic islands divergence, wherein divergent DNA segments are interspersed with low-divergence segments. Such should rare absent under but common in gene flow. Sympatric divergence endemic fishes known from isolated saline, crater, postglacial, ancient lakes. Two morphologically distinct cyprinid fishes,...
Nasopharyngeal carcinoma (NPC) is a major malignant tumor of the head and neck region in southern China. The understanding its underlying etiology essential for development novel effective therapies. We report first time that microRNA-940 (miR-940) significantly suppresses proliferation variety cancer cell lines, arrests cells cycle, induces caspase-3/7-dependent apoptosis inhibits formation NPC xenograft tumors mice. further show miR-940 directly binds to 3′-untranslated regions Nestin mRNA...
IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally. Increasing evidence suggests importance of host immunity in development IgAN, but its dynamics during early stage IgAN are still largely unclear.Here we successfully resolved transcriptomic changes immune cells by conducting single-cell RNA-sequencing (scRNA-seq) with peripheral blood mononuclear cells. The differentially expressed genes (DEGs) between control and were predominantly enriched NK cell-mediated...
The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, molecular identity through which JG respond to pressure remains unclear.Here we discovered that Piezo1, a mechanosensitive ion channel, was colocalized with mouse kidney as well As4.1 cells, commonly used cell line. Activation Piezo1 its agonist Yoda1 induced an intracellular calcium increase downregulated expression these while knockout abolished effect Yoda1....
East Lake in Wuhan, China, harbors a high number of freshwater fish species great conservation value, concurrently serving as vital resources for local livelihoods. However, the ecosystem is threatened by an array anthropogenic activities, thus requiring consistent monitoring community to enable more efficacious management. In place conventional surveying methods, we undertook first analysis distribution within via metabarcoding environmental DNA (eDNA). The accuracy and efficacy eDNA relies...
G protein–coupled estrogen receptor (GPER) might be involved in ulcerative colitis (UC), but the direct effect of GPER on UC is still unclear. We used male C57BL/6 mice to establish acute model with administration dextran sulfate sodium and explored its possible mechanism. The selective agonist G-1 inhibited weight loss colon shortening decreased disease activity index for histologic damage colitis. All these effects were prevented by a blocker. dysfunction tight junction protein expression...
Chemotherapy-induced intestinal mucositis (CIM) is a common adverse reaction to antineoplastic treatment with few appropriate, specific interventions. We aimed identify the role of G protein coupled estrogen receptor (GPER) in CIM and its mechanism. Adult male C57BL/6 mice were intraperitoneally injected 5-fluorouracil establish model. The selective GPER agonist G-1 significantly inhibited weight loss histological damage restored mucosal barrier dysfunction, including improving expression...