A5100617909- Bone fractures and treatments
- Organ Transplantation Techniques and Outcomes
- Orthopedic Surgery and Rehabilitation
- Mesenchymal stem cell research
- Hip disorders and treatments
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- RNA modifications and cancer
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Tissue Engineering and Regenerative Medicine
- Shoulder Injury and Treatment
- Renal and related cancers
- Anesthesia and Neurotoxicity Research
- Total Knee Arthroplasty Outcomes
- MicroRNA in disease regulation
- Intensive Care Unit Cognitive Disorders
- Foot and Ankle Surgery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pelvic and Acetabular Injuries
- Bioactive Natural Diterpenoids Research
- Cardiovascular Disease and Adiposity
Third Hospital of Hebei Medical University
2008-2025
Hebei Medical University
2008-2025
Xi'an Honghui Hospital
2025
Xi'an Jiaotong University
2025
First Affiliated Hospital of Zhengzhou University
2008-2025
Peking University
2019-2024
Peking University People's Hospital
2019-2024
Children's Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
First Affiliated Hospital of Xinjiang Medical University
2015-2023
Oil Red O (ORO) staining is a commonly used experimental technique to detect lipid content in cells or tissues. Freshly prepared ORO 60% isopropanol the most widely method at present. However, volatile and harmful human body. It will also affect interpretation of results due formation crystals non-specific diffuse staining. In this paper, by screening validation, we report salicylic acid ethanol solution (containing 50% ethanol, 5%-10% acid) for preparation solution, which has better effect...
Abstract Background Open reduction, superior plate (SP) fixation, and autologous cancellous granular bone grafting (ACGBG) are common strategies for treating clavicular midshaft atrophic nonunion (CMAN). We aimed to compare the radiological findings clinical effects of two grafts (ACBGs) those single SP treat CMAN. Methods This retrospective study comprised 62 patients admitted our hospital with CMAN (ACGBG fixation between March 2012 October 2017, 32 patients; structured [ACSBG] November...
Abstract Background Tumor immune escape is a pivotal gateway for esophageal squamous cell carcinoma (ESCC) development. Immune checkpoint-blocking therapies, represented by programmed death receptor-1/ligand 1 (PD-1/PD-L1) inhibitors, have achieved remarkable breakthroughs in ESCC treatment. However, not all patients with receive satisfactory clinical benefit. Therefore, identifying novel biomarkers predicting the efficacy of immunotherapy great importance. Methods CircNF1 was screened from...
Specific polymorphisms in the vitamin D receptor (VDR) gene have been associated with genetic susceptibility to inflammatory bowel disease (IBD) different ethnic populations.A total of 218 ulcerative colitis (UC) patients and 251 healthy controls were genotyped for VDR using PCR-restriction fragment length polymorphism (PCR-RFLP) assay. (Apa I, Taq Bsm I Fok I) analyzed both genotypic phenotypic susceptibilities.Among four examined polymorphisms, showed a slightly higher distribution our...
Background: Postoperative delirium (POD) is of great concern as a complication surgery in older adult patients. Sedation strategies influence the development POD. This study compared how sedation administered during spinal anesthesia influenced POD patients aged ≥ 65 years undergoing elective for hip fracture repair. Patients and Methods: A randomized clinical trial was conducted from 1 August 2021 to 30 June 2022 at single academic medical center. Two hundred twenty-six were randomly...
Tumor-associated neutrophils (TANs) are heterogeneous; thus, their roles in tumor development could vary depending on the cancer type. Here, we showed that TANs affect metabolic dysfunction-associated steatohepatitis hepatocellular carcinoma (MASH-related HCC) more than viral-associated HCC. We attributed this difference to predominance of SiglecFhi MASH-related HCC tumors. Linoleic acid and GM-CSF, which commonly elevated microenvironment, fostered c-Myc-driven TAN subset. Through TGFβ...
Chemotherapy-induced intestinal mucositis (CIM) is a common adverse reaction to antineoplastic treatment with few appropriate, specific interventions. We aimed identify the role of G protein coupled estrogen receptor (GPER) in CIM and its mechanism. Adult male C57BL/6 mice were intraperitoneally injected 5-fluorouracil establish model. The selective GPER agonist G-1 significantly inhibited weight loss histological damage restored mucosal barrier dysfunction, including improving expression...
Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor with poor prognosis, predominantly CA19-9 positive. High levels correlate increased aggressiveness and worse outcomes. This study employs multi-omics analysis to reveal molecular features identify therapeutic targets of positive ICC, aiming support individualized treatment. Data from seven clinical cohorts, two whole-exome sequencing six RNA sequencing/microarray one proteomic cohort, 20 single-cell samples, spatial transcriptome...
Our previous studies reported that urine-derived stem cells (USCs) possess a strong self-renewal ability and multidirectional differentiation potential thus are an ideal candidate cell source for hepatocellular transplantation. USC transplantation may repair the pathological changes of chronic liver injury to certain extent, hypoxia pretreatment improve recovery efficiency USCs. Therefore, present study aimed investigate possible mechanism improved hypoxia-pretreated A model was established...
Intrahepatic cholangiocarcinoma (ICC), a highly malignant tumor characterized by poor prognosis, has shown limited response to conventional treatments. Recently, advances in immunotherapy have offered new hope for treating such tumors. This article reviews the immune microenvironment (TIME) of ICC, its pivotal role immunotherapy, and methods enhance ICC treatment converting ‘cold tumors’ ‘hot through activation. Additionally, examines characteristics checkpoint inhibitors their essential...
The relationship between inflammation and venous thromboembolism (VTE) has not been fully elucidated.Based on our previous studies, we detected the plasma levels of serum amyloid A protein (SAA), interleukin-1 (IL-1), tumor necrosis factor-a (TNF-a) their 8 gene polymorphisms by ELISA a multiplex ligation detection reaction (iMLDR) method in 284 patients with VTE 268 healthy controls.Levels SAA (P=0.032), IL-1 (P=0.045), TNF-a (P=0.040) were significantly higher group than control group....
Urine-derived stem cells (USCs) are adult isolated from urine with strong proliferative ability and differentiation potentials. Cell transplantation of USCs could partly repair liver injury. It has been reported that the bone mesenchymal in patients chronic failure is significantly lower than without disease. The aim this study was therefore to evaluate biological characteristics end-stage disease (LD-USCs, disease) compared those normal healthy individuals (N-USCs, individuals), a view...
Objective: To investigate the morphological changes of deep fascia subjected to distraction in a rabbit model leg lengthening. Methods: The animal lengthening was established 20 New Zealand white rabbits using unilateral external fixator with 4 half pins medially fixed tibia, and osteotomy performed between second third pins. initiated 7 days after procedure, rate 1 2 mm/d steps, proceeded until 10% 20% increases initial length tibia had been achieved. samples were studied by...