A5074674277- Immune Cell Function and Interaction
- Complement system in diseases
- T-cell and B-cell Immunology
- Recommender Systems and Techniques
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Image and Video Quality Assessment
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Topic Modeling
- Liver physiology and pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Sphingolipid Metabolism and Signaling
- Mobile Crowdsensing and Crowdsourcing
- Expert finding and Q&A systems
University of Hong Kong
2004-2025
HKU-Pasteur Research Pole
2024
Chinese University of Hong Kong
2012-2024
University of Hong Kong - Shenzhen Hospital
2024
Queen Mary Hospital
2024
Hong Kong Jockey Club
2024
Imperial College London
2011-2021
Centre for Inflammation Research
2013-2016
Chinese University of Hong Kong, Shenzhen
2012-2013
National Institute of Pathology
2007
Most existing recommender systems focus on modeling the ratings while ignoring abundant information embedded in review text. In this paper, we propose a unified model that combines content-based filtering with collaborative filtering, harnessing of both and reviews. We apply topic techniques text align topics rating dimensions to improve prediction accuracy. With text, can alleviate cold-start problem. Furthermore, our is able learn latent are interpretable. these interpretable topics,...
Abstract Complement C1q is the activator of classical pathway. However, it now recognized that can exert functions unrelated to complement activation. Here we show C1q, but not C4, expressed in stroma and vascular endothelium several human malignant tumours. Compared with wild-type (WT) or C3- C5-deficient mice, C1q-deficient ( C1qa −/− ) mice bearing a syngeneic B16 melanoma exhibit slower tumour growth prolonged survival. This effect attributable differences tumour-infiltrating immune...
Complement is a CD8 + T cell metabolic rheostat Systemic lupus erythematosus (SLE) associated with deficiencies in the complement protein C1q. Although C1q plays role clearance of apoptotic cells, there are several redundant pathways. Disruption one pathway does not lead to an autoimmune defect. In chronic graft-versus-host disease model SLE, Ling et al. show that dampens responses self-antigens. modulates metabolism through mitochondrial cell-surface p32/gC1qR. The lack during viral...
Abstract Tuned and distinct responses of macrophages dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate adaptive immunity. However, molecule(s) that confer these cell-type-specific LPS-induced effects remain poorly understood. Here we report integrin α M (CD11b) positively regulates signalling pathways selectively in myeloid but not macrophages. In cells, which express lower levels CD14 TLR4 than macrophages,...
Significance C1q is a well-known initiator of the complement classical pathway and interacts with several immune nonimmune cells inducing activation-independent functions. Endothelial represent one potential targets that binds to cell surface-expressed receptors stimulates inflammation. Here we report unique hitherto unrecognized function promote angiogenesis acting through globular heads. The angiogenic activity was supported by its ability induce new vessel formation in vitro vivo models...
Abstract The majority of patients with systemic lupus erythematosus (SLE) have high expression type I IFN-stimulated genes. Mitochondrial abnormalities also been reported, but the contribution IFN exposure to these changes is unknown. Here, we show downregulation mitochondria-derived genes and mitochondria-associated metabolic pathways in IFN-High from transcriptomic analysis CD4 + CD8 T cells. cells enlarged mitochondria lower spare respiratory capacity associated increased cell death upon...
Identifying signals that govern the differentiation of tumor-infiltrating CD8+ T cells (CD8+ TILs) toward exhaustion can improve current therapeutic approaches for cancer. Here, we show type I interferons (IFN-Is) act as environmental cues, enhancing terminal cell in tumors. We find enrichment IFN-I-stimulated genes (ISGs) within exhausted (Tex cells) patients across various cancer types, with heightened ISG levels correlating poor response to immune checkpoint blockade (ICB) therapy. In...
SARS-CoV-2 has been confirmed in over 450 million cases since 2019. Although several vaccines have certified by the WHO and people are being vaccinated on a global scale, it reported that multiple variants can escape neutralization antibodies, resulting vaccine breakthrough infections. Bacillus Calmette-Guérin (BCG) is known to induce heterologous protection based trained immune responses. Here, we investigated whether BCG-induced immunity protected against K18-hACE2 mouse model. Our data...
The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface on monocytes, neutrophils, macrophages and dendritic cells that plays crucial role in several immunological processes including leukocyte extravasation phagocytosis. minor allele of non-synonymous CR3 polymorphism (rs1143679, conversation arginine to histidine at position 77: R77H) represents one the strongest genetic risk factor human systemic lupus erythematosus, with heterozygosity (77R/H) being most common disease...
Abstract Host survival depends on the elimination of virus and mitigation tissue damage. Herein, we report modulation D-mannose flux rewires virus-triggered immunometabolic response cascade reduces Safe inexpensive can compete with glucose for same transporter hexokinase. Such competitions suppress glycolysis, reduce mitochondrial reactive-oxygen-species succinate-mediated hypoxia-inducible factor-1α, thus virus-induced proinflammatory cytokine production. The combinatorial treatment by...
Abstract BACKGROUND The consumption of tobacco and alcohol has been implicated in the development head neck squamous cell carcinoma (HNSCC). Promoter methylation tumor suppressor genes is common HNSCC. In this study, authors evaluated effects on p15 gene cells from mouth throat physically healthy individuals patients with METHODS study participants were divided into 3 groups, including a group 37 nonsmokers nondrinkers, 22 smokers and/or drinkers 31 RESULTS Methylation was detected obtained...
Advanced strategies to interconvert cell types provide promising avenues model cellular pathologies and develop therapies for neurological disorders. Yet, methods directly transdifferentiate somatic cells into multipotent induced neural stem (iNSCs) are slow inefficient, it is unclear whether pass through a pluripotent state with full epigenetic reset. We report iNSC reprogramming from embryonic aged mouse fibroblasts as well human blood using an engineered Sox17 (eSox17FNV). eSox17FNV...
Collaborative filtering (CF), aiming at predicting users' unknown preferences based on observational from some users, has become one of the most successful methods to building recommender systems. Various approaches CF have been proposed in this area, but seldom do they consider dynamic scenarios: 1) new items arriving system, 2) users joining system; or 3) rating updating system are all dynamically obtained with respect time. To capture these changes, paper, we develop an online learning...
Recommender systems are promising for providing personalized favorite services. Collaborative filtering (CF) technologies, making prediction of users' preference based on previous behaviors, have become one the most successful techniques to build modern recommender systems. Several challenging issues occur in previously proposed CF methods: (1) methods ignore response patterns and may yield biased parameter estimation suboptimal performance; (2) some adopt heuristic weight settings, which...
Acquiring protective immunity through vaccination is essential, especially for patients with type 2 diabetes who are vulnerable adverse clinical outcomes during coronavirus disease 2019 (COVID-19) infection. Type (T2D) associated immune dysfunction. Here, we evaluated the impact of T2D on immunological responses induced by mRNA (BNT162b2) and inactivated (CoronaVac) vaccines, two most commonly used COVID-19 vaccines. The study consisted parts. In Part 1, sera titres IgG antibodies against...
Tumor-associated neutrophils (TANs) are heterogeneous; thus, their roles in tumor development could vary depending on the cancer type. Here, we showed that TANs affect metabolic dysfunction-associated steatohepatitis hepatocellular carcinoma (MASH-related HCC) more than viral-associated HCC. We attributed this difference to predominance of SiglecFhi MASH-related HCC tumors. Linoleic acid and GM-CSF, which commonly elevated microenvironment, fostered c-Myc-driven TAN subset. Through TGFβ...
Mature neutrophils are notoriously short-lived immune cells that cannot be genetically manipulated. Analysis of gene function therefore requires modified animals, which is expensive, time-consuming, and costly in animal life. a physiologically relevant context thus represents significant problem the field. We sought to overcome this obstruction field by developing strategy for analysis context. Here, we demonstrate functional relevance vitro conditional-Hoxb8 immortalized precursor-derived...
The dendritic cell (DC)-based tumor immunotherapy has been a new promise of cure for cancer patients, but animal studies and clinical trials have thus far only shown limited success, especially in treating established tumors. Certain immunosuppressive mechanisms triggered by cells or the derivatives are believed to be major obstacle. We studied role DC-derived IL-10 its negative impact on vaccine efficacy mouse models. Liver were injected via portal vein, giving rise disseminated...
To define the role of IL-10 in lupus pathogenesis, and to understand immunological mechanisms underlying resistance vs susceptibility disease induction by dendritic cells (DCs) dying cells.Groups IL-10-deficient normal C57BL/6 mice were injected with syngenic DCs that had ingested necrotic prepared either freeze-thaw cycle (DC/nec(F/T)) or heat shock (DC/nec(H/S)) procedures, DC alone, PBS only. Disease development, including proteinuria renal pathological changes, was monitored. Levels...
Abstract The complement component C1q is known to play a controversial role in the pathogenesis of systemic lupus erythematosus, but underlying mechanisms remain poorly understood. Intraperitoneal injection pristane induces lupus-like syndrome whose implicates secretion type I IFN by CD11b+ Ly6Chigh inflammatory monocytes TLR7-dependent fashion. was also shown influence IFN-α. In this study, we explored whether deficiency could affect pristane-induced lupus. Surprisingly, C1qa−/− mice...