A5006656816- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Electron Spin Resonance Studies
- Acute Ischemic Stroke Management
- Nitric Oxide and Endothelin Effects
- Caveolin-1 and cellular processes
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Advanced Glycation End Products research
- Barrier Structure and Function Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Flavonoids in Medical Research
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Plant-based Medicinal Research
- Chronic Kidney Disease and Diabetes
- Acupuncture Treatment Research Studies
- Natural product bioactivities and synthesis
- Lipid metabolism and disorders
University of Hong Kong
2015-2024
Chinese University of Hong Kong
2012-2024
Xuzhou Medical College
2020-2024
ShenZhen People’s Hospital
2022
City University of Hong Kong, Shenzhen Research Institute
2015-2021
Nanfang Hospital
2014-2021
Southern Medical University
1995-2021
Guangzhou University of Chinese Medicine
2018-2019
Shenzhen Second People's Hospital
2018
Chinese University of Hong Kong, Shenzhen
2016
J. Neurochem. (2012) 120 , 147–156. Abstract The roles of caveolin‐1 (cav‐1) in regulating blood–brain barrier (BBB) permeability are unclear yet. We previously reported that cav‐1 was down‐regulated and the production nitric oxide (NO) induced loss focal cerebral ischemia reperfusion injury. present study aims to address whether impacts on BBB matrix metalloproteinases (MMPs) activity during ischemia‐reperfusion found expression isolated cortex microvessels, hippocampus, ischemic brain....
Angiogenesis is crucial for cancer initiation, development and metastasis. Identifying natural botanicals targeting angiogenesis has been paid much attention drug discovery in recent years, with the advantage of increased safety. Isoliquiritigenin (ISL) a dietary chalcone-type flavonoid various anti-cancer activities. However, little known about anti-angiogenic activity isoliquiritigenin its underlying mechanisms. Herein, we found that ISL significantly inhibited VEGF-induced proliferation...
Previous findings have indicated the potential benefits of Chinese traditional medicine Qiliqiangxin (QLQX) in heart failure. Here we performed a double-blind, randomized controlled trial to evaluate efficacy and safety QLQX patients with failure reduced ejection fraction (HFrEF). This multicenter trial, conducted 133 hospitals China, enrolled 3,110 HFrEF NT-proBNP levels ≥450 pg ml
Early blood-brain barrier (BBB) disruption resulting from excessive neurovascular proteolysis by matrix metalloproteinases (MMPs) is closely associated with hemorrhagic transformation events in ischemic stroke. We have shown that normobaric hyperoxia (NBO) treatment reduces MMP-9 increase the brain. The aim of this study was to determine whether NBO could attenuate MMP-9-mediated early BBB following Rats were exposed (95% O(2)) or normoxia (30% during 90-min middle cerebral artery occlusion,...
Abstract Wearing masks has been a recommended protective measure due to the risks of coronavirus disease 2019 (COVID‐19) even in its coming endemic phase. Therefore, deploying “smart mask” monitor human physiological signals is highly beneficial for personal and public health. This work presents smart mask integrating an ultrathin nanocomposite sponge structure‐based soundwave sensor (≈400 µm), which allows high sensitivity wide‐bandwidth dynamic pressure range, i.e., capable detecting...
Abstract Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia–reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification proteins. High-mobility group box 1 (HMGB1) oxidation, particularly disulfide HMGB1 formation, facilitates secretion release activates neuroinflammation, aggravating I/R injury. However, cellular sources MPO/HOCl ischemic brain are unclear yet. Whether HOCl could promote remains unknown. In present study,...
Scalp acupuncture (SA) is a commonly used therapeutic approach for stroke throughout China and elsewhere in the world. The objective of this study was to assess clinical efficacy safety SA acute ischemic stroke. A systematical literature search 6 databases conducted identify randomized controlled trials (RCTs) compared with western conventional medicines (WCMs). All statistical analyses were performed by Rev Man Version 5.0. Eight studies 538 participants included studies. deemed have an...