A5076956379- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Air Quality and Health Impacts
- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Traditional Chinese Medicine Analysis
- Phytochemical compounds biological activities
- Liver Disease and Transplantation
- Bioactive natural compounds
- Genomics, phytochemicals, and oxidative stress
- Insect Utilization and Effects
- Ferroptosis and cancer prognosis
- Microbial Natural Products and Biosynthesis
- Insect Pest Control Strategies
- Health, Environment, Cognitive Aging
- Chromatography in Natural Products
- Intracerebral and Subarachnoid Hemorrhage Research
- Toxin Mechanisms and Immunotoxins
- Cognitive Abilities and Testing
- Extracellular vesicles in disease
- Chemical Synthesis and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Neurogenesis and neuroplasticity mechanisms
- Ginseng Biological Effects and Applications
- Genetic Associations and Epidemiology
National Health and Family Planning Commission
2021-2025
Shanghai University of Traditional Chinese Medicine
2020-2025
Xi'an Jiaotong University
2021-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
University of Hong Kong
2019-2022
City University of Hong Kong, Shenzhen Research Institute
2021-2022
Chinese University of Hong Kong
1988-2022
Zunyi Medical University
2021
Fourth Affiliated Hospital of China Medical University
2020
Nanjing University of Chinese Medicine
2020
The abortifacient proteins trichosanthin, α‐momorcharin and β‐momorcharin at nM concentrations inhibit cell‐free protein synthesis. momorcharins the ribosome‐inactivating isolated from Momordica charantia seeds cross‐react with respective antisera. saporins, pokeweed antiviral (PAP) and, to a lesser extent, gelonin have activity on pregnant mice.
The absence of a productive cell culture system hampered detailed analysis the structure and protein composition hepatitis E virion. In this study, virus from robust HEV feces infected monkeys at peak excretion was purified by ultra-centrifugation. common feature two samples after ultracentrifugation that ORF2 mainly remained in top fractions. glycosylated, with an apparent molecular weight 88 kDa, not infectious PLC/PRF/5 cells. fraction can bind to protect RNA digestion RNase A. RNA-ORF2...
Breast cancer (BCa) is the leading cause of women’s death worldwide; among them, triple‐negative breast (TNBC) one most troublesome subtypes with easy recurrence and great aggressive properties. Spatholobus suberectus Dunn has been used in clinic Chinese society for hundreds years. Shreds evidence showed that a favorable outcome management cancer. However, anti‐TNBC efficacy percolation extract (SSP) its underlying mechanisms have not fully elucidated. Hence, present study aimed at...
Cytochrome P450 3A4 (CYP3A4) is a key mediator in xenobiotic metabolism and drug-drug interactions (DDI), developing orally active fluorogenic substrates for sensing imaging of target enzyme biological systems remains challenging. Here, an artificial intelligence (AI)-driven strategy used to construct highly specific substrate CYP3A4 complex systems. After the fusion AI-selected drug-like fragment with CYP3A4-preferred fluorophore, three candidates are designed synthesized. Among all...
Abstract Background Stroke is the leading cause of long-term motor disability and cognitive impairment. Recently, neurogenesis has become an attractive strategy for chronic recovery stroke. It important to understand molecular mechanism that promotes neural stem cell (NSC) future NSC-based therapies. Our previous study showed Momordica charantia polysaccharides (MCPs) exerted neuroprotective effects on stroke via their anti-oxidant anti-inflammation activities. However, it remains unknown...
It has been well documented that Momordica charantia polysaccharide (MCP) multiple biological effects such as immune enhancement, anti-oxidation and anti-cancer. However, the potential protective of MCP on stroke damage its relative mechanisms remain unclear. Our present study demonstrated could scavenge reactive oxygen species (ROS) in intra-cerebral hemorrhage damage, significantly attenuating neuronal death induced by thrombin primary hippocampal neurons. Furthermore, we found prevented...
The current COVID-19 pandemic caused by SARS-Cov-2 is responsible for more than 6 million deaths globally. development of broad-spectrum and cost-effective antivirals urgently needed. Medicinal plants are renowned as a complementary approach in which antiviral natural products have been established safe effective drugs. Here, we report that the percolation extract Spatholobus suberectus Dunn (SSP) viral entry inhibitor against SARS-CoV-1/2 other enveloped viruses. inhibitory activities SSP...
It has been demonstrated that Src could modulate NMDA receptor, and PAR1 also affect NMDAR signaling. However, whether regulate through under ICH not yet investigated. In this study, we the role of Src-PSD95-GluN2A signaling cascades in rat model vitro thrombin challenged model. Using agonist SFLLR, antagonist RLLFS inhibitor PP2, electrophysiological analysis showed regulated NMDA-induced whole-cell currents (INMDA) though primary cultured neurons. Both vivo results elevated phosphorylation...
Background: Glioma is the most common tumor of central nervous system. Hericium erinaceus, which has been reported to have a variety pharmacological activities, widely used Traditional Chinese Medicine (TCM), and also kind delicious food accepted by public. Methods Results: In this study, two new natural products, compounds 1 2, were isolated identified from erinaceus. They named erinacerin O P, respectively, after structural identification, their effects on human glioma cell line U87...