A5089021404- Gut microbiota and health
- Genetic Associations and Epidemiology
- Selenium in Biological Systems
- Tryptophan and brain disorders
- Clostridium difficile and Clostridium perfringens research
- Trace Elements in Health
- Genetics and Neurodevelopmental Disorders
- Sleep and related disorders
- Eating Disorders and Behaviors
- Child and Adolescent Psychosocial and Emotional Development
- Obesity, Physical Activity, Diet
- Air Quality and Health Impacts
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Health disparities and outcomes
- Osteoarthritis Treatment and Mechanisms
- Health, Environment, Cognitive Aging
- Gout, Hyperuricemia, Uric Acid
- Coffee research and impacts
- Nutritional Studies and Diet
- Virus-based gene therapy research
- Heavy Metal Exposure and Toxicity
- Adolescent and Pediatric Healthcare
- Bioinformatics and Genomic Networks
Xi'an Jiaotong University
2019-2025
National Health and Family Planning Commission
2019-2025
Northwest Women's and Children's Hospital
2025
College of Marin
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Ministry of Education of the People's Republic of China
2022
ORCID
2021
China XD Group (China)
2021
Second Military Medical University
1996
Changhai Hospital
1996
The intermittent flow cold storage heat exchanger is one of the most important components pulse tube expansion refrigerator based on reverse Brayton cycle. In experimental system, volume and transfer helical play a decisive role in stable operation whole system. However, there are few studies under helium working medium conditions. this paper, process method for calculating proposed gas vessel dynamics model. Subsequently, three-dimensional simulation model was established to analyze...
The genetic underpinnings of RA remain partially elucidated, motivating our exploration copy number variations (CNV) and rare in the pathogenesis RA. We conducted an integrated analysis genome-wide landscape CNV exome-wide variation associations with UK Biobank. To strengthen findings, we corroborated results by differentially expressed genes identified from gene expression profiles synovial tissue patients health controls. Furthermore, leveraged Drug-Gene Interaction Database to explore...
Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, role of interaction between dysbiosis C-reactive protein (CRP) in development anxiety depression remains to be elucidated. In this study, a total 3321 independent single nucleotide polymorphism (SNP) loci associated with were driven from genome-wide association study (GWAS). Using individual level genotype data UK Biobank, we then calculated polygenetic risk...
Background Growing evidence supports that alterations in the gut microbiota play an essential role etiology of anxiety, depression, and other psychiatric disorders. However, potential effect oral on mental health has received little attention. Methods Using latest genome-wide association study (GWAS) summary data microbiome, polygenic risk scores (PRSs) 285 salivary microbiomes 309 tongue dorsum were conducted. Logistic linear regression models applied to evaluate relationship between...
Abstract The aim of this study was to investigate the possible interaction mitochondrial dysfunction and inflammatory cytokines in risk anxiety depression. We utilized UK Biobank for sample study. A mitochondria-wide association(MiWAS) analysis performed effects DNA (mtDNA)×C-reactive protein (CRP) on risks self-reported ( N = 72,476), general disorder (GAD-7) scores 80,853), depression 80,778), Patient Health Questionnaire (PHQ-9) 80,520) total samples, females males, respectively,...
Longevity is one of the most complex phenotypes, and its genetic basis remains unclear. This study aimed to explore correlation potential causal association between gut microbiota longevity.
Previous studies have suggested that vitamin D (VD) was associated with psychiatric diseases, but efforts to elucidate the functional relevance of VD depression and anxiety from genetic perspective been limited. Based on UK Biobank cohort, we first calculated polygenic risk score (PRS) for genome-wide association study (GWAS) data VD. Linear logistic regression analysis were conducted evaluate associations traits traits, respectively. Then, using individual genotype phenotype Biobank,...
T-2 toxin and deoxynivalenol (DON) are two prevalent mycotoxins that cause cartilage damage in Kashin-Beck disease (KBD). Cartilage extracellular matrix (ECM) degradation chondrocytes is a significant pathological feature of KBD. It has been shown the Hippo pathway involved ECM degradation. This study aimed to examine effect YAP, major regulator pathway, on hiPS-derived (hiPS-Ch) model The hiPS-Ch injury models were established via treatment with toxin/DON alone or combination. We found DON...
Despite cumulative evidence showing obesity is associated with changes in sleep quality and quantity, the study about relationships between body composition scarce, whether relationship causal remains unknown. In this study, we examined there are associations composition.First, estimated genetic correlations sleep-related phenotypes using linkage disequilibrium score regression (LDSC). Mendelian randomization (MR) analysis was then conducted to test 2-way on significant associations....
Most previous genetic studies of sleep behaviors were conducted individually, without comprehensive consideration the complexity various behaviors. Our aim is to identify architecture and potential biomarker health score, which more powerfully represents overall traits.We a genome-wide association study (GWAS) score (overall assessment duration, snoring, insomnia, chronotype, daytime dozing) using 336,463 participants from UK Biobank. Proteome-wide (PWAS) transcriptome-wide (TWAS) then...
Abstract We aim to systematically explore the potential genetic correlations between five major psychiatric disorders and gestational ages. Genome‐wide association study (GWAS) summary datasets of attention deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), schizophrenia (SCZ) depressive (MDD) in discovery were downloaded from Psychiatric GWAS Consortium (PGC) website. Suggestive (Raw p < 0.05) associations phrase further replicated independent GWASs which PGC,...
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with GWAS dataset, respectively, to conduct a proteome-wide study (PWAS) analysis. Then transcriptome weights (Rnaseq Splicing) were applied transcriptome-wide (TWAS) Finally, PWAS TWAS results investigated...
Observational studies highlight associations of common diseases with individual schizophrenia symptoms. However, it is unclear whether these are associated treatment-resistant (TRS). We aimed to explore the genetic between immune diseases, metabolic psychiatric disorders, gut microbiota and TRS.Genome-wide association study (GWAS) summary data European participants (n = ∼456,327) included TRS, 11 23 body mass index, height, 211 microbiota. In this correlation two-sample Mendelian...
Abstract Background Depression has been linked to an increased risk of cardiovascular and respiratory diseases; however, its impact on cardiac lung function remains unclear, especially when accounting for potential gene–environment interactions. Methods We developed a novel polygenic interaction score (PGIRS) integrating the major genetic effect depression-associated loci. The single nucleotide polymorphisms (SNPs) demonstrating or environmental were obtained from genome-wide SNP association...