A5103084817- Gut microbiota and health
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Clostridium difficile and Clostridium perfringens research
- Sleep and related disorders
- Obesity, Physical Activity, Diet
- Health disparities and outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Eating Disorders and Behaviors
- Air Quality and Health Impacts
- Diet and metabolism studies
- Coffee research and impacts
- Folate and B Vitamins Research
- Gastrointestinal motility and disorders
- Bipolar Disorder and Treatment
- Nutritional Studies and Diet
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Health, psychology, and well-being
- Vitamin D Research Studies
- Protein Degradation and Inhibitors
- Health, Environment, Cognitive Aging
- Biomarkers in Disease Mechanisms
Xi'an Jiaotong University
2021-2025
National Health and Family Planning Commission
2021-2025
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Nanjing Institute of Railway Technology
2024
Tianjin University of Technology
2024
Ministry of Education of the People's Republic of China
2022
China XD Group (China)
2021
Nanyang Medical College
2017
ShenZhen People’s Hospital
2015
The genetic underpinnings of RA remain partially elucidated, motivating our exploration copy number variations (CNV) and rare in the pathogenesis RA. We conducted an integrated analysis genome-wide landscape CNV exome-wide variation associations with UK Biobank. To strengthen findings, we corroborated results by differentially expressed genes identified from gene expression profiles synovial tissue patients health controls. Furthermore, leveraged Drug-Gene Interaction Database to explore...
Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, role of interaction between dysbiosis C-reactive protein (CRP) in development anxiety depression remains to be elucidated. In this study, a total 3321 independent single nucleotide polymorphism (SNP) loci associated with were driven from genome-wide association study (GWAS). Using individual level genotype data UK Biobank, we then calculated polygenetic risk...
Background Growing evidence supports that alterations in the gut microbiota play an essential role etiology of anxiety, depression, and other psychiatric disorders. However, potential effect oral on mental health has received little attention. Methods Using latest genome-wide association study (GWAS) summary data microbiome, polygenic risk scores (PRSs) 285 salivary microbiomes 309 tongue dorsum were conducted. Logistic linear regression models applied to evaluate relationship between...
Abstract The aim of this study was to investigate the possible interaction mitochondrial dysfunction and inflammatory cytokines in risk anxiety depression. We utilized UK Biobank for sample study. A mitochondria-wide association(MiWAS) analysis performed effects DNA (mtDNA)×C-reactive protein (CRP) on risks self-reported ( N = 72,476), general disorder (GAD-7) scores 80,853), depression 80,778), Patient Health Questionnaire (PHQ-9) 80,520) total samples, females males, respectively,...
Longevity is one of the most complex phenotypes, and its genetic basis remains unclear. This study aimed to explore correlation potential causal association between gut microbiota longevity.
Previous studies have suggested that vitamin D (VD) was associated with psychiatric diseases, but efforts to elucidate the functional relevance of VD depression and anxiety from genetic perspective been limited. Based on UK Biobank cohort, we first calculated polygenic risk score (PRS) for genome-wide association study (GWAS) data VD. Linear logistic regression analysis were conducted evaluate associations traits traits, respectively. Then, using individual genotype phenotype Biobank,...
Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but effect their interactions on risk depression remains unclear. We aim to analyze between gut IBD explore candidate genes involving interactions.Using individual genotype traits data from UK Biobank, we calculated polygenetic scores (PRS) 114 microbiome, ulcerative colitis (UC), Crohn's (CD), total (CD + UC) respectively. The effects were assessed through a linear regression model....
Despite cumulative evidence showing obesity is associated with changes in sleep quality and quantity, the study about relationships between body composition scarce, whether relationship causal remains unknown. In this study, we examined there are associations composition.First, estimated genetic correlations sleep-related phenotypes using linkage disequilibrium score regression (LDSC). Mendelian randomization (MR) analysis was then conducted to test 2-way on significant associations....
Most previous genetic studies of sleep behaviors were conducted individually, without comprehensive consideration the complexity various behaviors. Our aim is to identify architecture and potential biomarker health score, which more powerfully represents overall traits.We a genome-wide association study (GWAS) score (overall assessment duration, snoring, insomnia, chronotype, daytime dozing) using 336,463 participants from UK Biobank. Proteome-wide (PWAS) transcriptome-wide (TWAS) then...
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with GWAS dataset, respectively, to conduct a proteome-wide study (PWAS) analysis. Then transcriptome weights (Rnaseq Splicing) were applied transcriptome-wide (TWAS) Finally, PWAS TWAS results investigated...
Abstract Background Depression has been linked to an increased risk of cardiovascular and respiratory diseases; however, its impact on cardiac lung function remains unclear, especially when accounting for potential gene–environment interactions. Methods We developed a novel polygenic interaction score (PGIRS) integrating the major genetic effect depression-associated loci. The single nucleotide polymorphisms (SNPs) demonstrating or environmental were obtained from genome-wide SNP association...
Abstract Background The identification of suitable biomarkers is crucial clinical importance for the early diagnosis treatment-resistant schizophrenia (TRS). This study aims to comprehensively analyze association between TRS and blood urine biomarkers. Methods Candidate TRS-related single nucleotide polymorphisms (SNPs) were obtained from a recent genome-wide study. UK Biobank cohort, comprising 376,807 subjects with biomarker testing data, was used calculate polygenic risk score (PRS) TRS....
Purpose: Previous studies have demonstrated the link between micronutrients and mental health. However, it remains uncertain whether this connection is causal. We aim to investigate potential causal effects of on health based linkage disequilibrium score (LDSC) regression Mendelian randomization (MR) analysis. Methods: Utilizing publicly available genome-wide association study (GWAS) summary datasets, we performed LDSC MR analysis identify candidate with Single nucleotide polymorphisms...