A5039613849- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Bone Metabolism and Diseases
- Eosinophilic Esophagitis
- Bone health and osteoporosis research
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Sleep and related disorders
- Gastrointestinal motility and disorders
- Bioinformatics and Genomic Networks
- Eating Disorders and Behaviors
- Sleep and Wakefulness Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- Technology Use by Older Adults
- Growth Hormone and Insulin-like Growth Factors
- Genetic and phenotypic traits in livestock
- Coffee research and impacts
- Biochemical Analysis and Sensing Techniques
- Gout, Hyperuricemia, Uric Acid
- Congenital gastrointestinal and neural anomalies
Xi'an Jiaotong University
2022-2024
National Health and Family Planning Commission
2022-2024
Abstract Infection‐induced perturbation of immune homeostasis could promote psychopathology. Psychiatric sequelae have been observed after previous coronavirus outbreaks. However, limited studies were conducted to explore the potential interaction effects inflammation and disease 2019 (COVID‐19) on risks anxiety depression. In this study, first, polygenic risk scores (PRS) calculated for eight COVID‐19 clinical phenotypes using individual‐level genotype data from UK Biobank. Then, linear...
Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects mitochondrial dysfunction lifestyle on BMD, respectively. However, their interaction BMD are still unclear. Therefore, we aimed to investigate possible DNA (mtDNA) common lifestyles contributing osteoporosis.
Abstract Intelligence quotient is a vital index to evaluate the ability of an individual think rationally, learn from experience and deal with environment effectively. However, limited efforts have been paid explore potential associations intelligence traits tissue proteins brain, CSF plasma. The information protein quantitative trait loci was collected recently released genome-wide association study conducted on quantification data tissues including Using individual-level genotypic UK...
Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but effect their interactions on risk depression remains unclear. We aim to analyze between gut IBD explore candidate genes involving interactions.Using individual genotype traits data from UK Biobank, we calculated polygenetic scores (PRS) 114 microbiome, ulcerative colitis (UC), Crohn's (CD), total (CD + UC) respectively. The effects were assessed through a linear regression model....
Background A bidirectional relationship between chronic pain (CP) and mental disorders has been reported, coffee was believed to be associated with both. However, the association of in this remains unclear. We aim analyze consumption on CP depression anxiety.Methods total 376,813 participants from UK Biobank were included. collected data anxiety, objects our study population. The anxiety assessed through logistic/linear regression models. Moreover, seemingly unrelated estimation test (SUEST)...
The objectives of this study were to investigate the interaction mitochondrial DNA (mtDNA) and lifestyle factors in development psychiatric disorders gain greater insight into their pathogenesis comorbidity. We analyzed data from approximately 150,000 individuals UK Biobank. Mitochondrial gene-by-environment studies (mtGEIS) performed assess relationships between mtDNA disorders, such as anxiety, depression, self-harm. These defined using diagnostic severity indicators derived General...
Abstract Objective Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification and developing better-tailored therapeutic targets. Methods TRS-related proteome-wide association studies (PWAS) were conducted on genome-wide (GWAS) from CLOZUK the Psychiatric Genomics Consortium (PGC), which provided TRS individuals...
This study investigates the cellular origin and tissue heterogeneity in bipolar disorder (BD) by integrating multiomics data. Four distinct datasets were employed, including single-cell RNA sequencing (scRNA-seq) data (embryonic fetal brain, n = 8, 1,266 cells), BD Assay for Transposase-Accessible Chromatin using (ATAC-seq) (adult 210), bulk RNA-seq 314), genome-wide association (GWAS) summary (n 413,466). The integration of scRNA-seq with relevant to was accomplished disease relevance score...
There is a strong link between irritable bowel syndrome and brain volumes, yet, to date, research examining the mediators of this association has been little. Based on phenotypic data 15 248 participants from UK Biobank, two-stage mediation analysis was performed assess among anxiety, syndrome. In first stage, we identified candidate mediating role anxiety for associated with volumes using regression models. Then, quantified magnitude effects by evaluating average causal-mediated effect...
Objective: Bitter or sweet beverage perception is associated with alterations in brain structure and function. Our aim to analyze the genetic association between bitter human proteins. Materials methods: In our study, 8356 11,518 proteins were first collected from two reference datasets of proteomes, ROS/MAP Banner. The perception-related proteome-wide studies (PWAS) then conducted by integrating recent genome-wide study (GWAS) data (n = 422,300) taste proteomes. gene expression profiles...
Background: Kashin–Beck disease (KBD) is a distinct osteoarthropathy in China with an unclear pathogenesis. This study aims to explore whether perturbations the intestine metabolome could be linked KBD individuals. Methods: An investigation was conducted endemic villages and fecal samples were collected. After applying inclusion exclusion criteria, total of 75 subjects enrolled for this study, including 46 (including 19 Grade I 27 II KBD) 29 controls. Untargeted metabolomics analysis...
Abstract Longitudinal changes in brain structure and lifestyle can affect sleep phenotypes. However, the influence of interaction between longitudinal on phenotypes remains unclear. Genome-wide association study dataset was obtained from published study. Phenotypic data lifestyles were UK Biobank cohort. Using genotype Biobank, we calculated polygenetic risk scores Linear/logistic regression analysis conducted to evaluate interactions duration, chronotype, insomnia, snoring daytime dozing....
<title>Abstract</title> Aims Addiction is currently seen as a neuropsychiatric disorder with genetic component involved. Multiple chronic bowel disorders could exert influence on mental status including addition. This study aims to investigate the correlation of addiction-related traits and disorders. Methods We extracted information from UK Biobank database. then calculated polygenic risk score (PRS) (ulcerative colitis (UC), Crohn’s disease (CD), UC + CD irritable syndrome (IBS)...
Abstract Background: Irritable bowel syndrome (IBS) and inflammatory diseases (IBD) were reported to be associated with mental disorders. But limited efforts made investigate the relationship between IBS/IBD risk of insomnia, especially from genetic perspective. Methods: Based on UK Biobank cohort, we first calculated polygenic scores (PRS) IBS IBD. Linear regression analyses conducted evaluate association PRS 7 sleep-related traits (N = 285,538-376,545), such as short sleep. Genome-wide...