A5101703365- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Ubiquitin and proteasome pathways
- Chemotherapy-induced cardiotoxicity and mitigation
- Fatty Acid Research and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Drug-Induced Hepatotoxicity and Protection
- Genetic Syndromes and Imprinting
- Aquaculture disease management and microbiota
- Neuroendocrine Tumor Research Advances
- Reproductive Biology and Fertility
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Genetic Associations and Epidemiology
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Analysis
- interferon and immune responses
- Pregnancy and preeclampsia studies
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Vitamin D Research Studies
- Microtubule and mitosis dynamics
Pfizer (United States)
2021-2025
Xi'an Jiaotong University
2024-2025
National Health and Family Planning Commission
2024
Union Hospital
2022
Jilin University
2022
The University of Texas MD Anderson Cancer Center
2000-2020
Heilongjiang University of Chinese Medicine
2019
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2017
Army Medical University
2017
Guangdong Provincial Center for Disease Control and Prevention
2016
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), key in chaperone-mediated autophagy (CMA) pathway, is elevated breast tumor tissues. However, exact effects and mechanisms CMA during cancer metastasis remain largely unknown. In this study, we found LAMP2A level was significantly human tissues, particularly metastatic carcinoma. The increased also positively correlated with histologic grade ductal cancer. High levels predicted shorter...
Abstract BPTF is a bromodomain and PHD finger domain-containing protein that serves as scaffolding subunit of the ISWI family member NURF chromatin remodeling complex. Together with interchangeable catalytic subunits SMARCA1 SMARCA5 additional RBBP4, RBBP7, complex catalyzes ATP to slide nucleosomes on DNA, exposing or occluding transcription factor binding sites, leading transcriptional activation repression. Dysregulation BPTF-containing complexes disrupts gene expression contributes...
Small-cell lung cancer (SCLC) is a heterogeneous disease, consisting of intratumoral and intertumoral neuroendocrine (ASCL1 and/or NEUROD1), mesenchymal-like, YAP-driven transcriptional states. Lysine-specific demethylase 1 (LSD1; also known as KDM1A) inhibitors have recently been progressed to clinical trials in SCLC based on promising preclinical antitumor activity. A potential limitation LSD1 the drug responses that observed cell lines patient-derived models. Based these observations, we...
We aimed to explore the mechanism of linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene enrichment (GSEA), and differential expression performed. Expression differentially expressed genes (DEGs) involved pathway mapped by using Pathview visualization. There 19 10 biological processes disease group healthy group, respectively. 9 KEGG pathways group. Linoleic was...
This study investigates the cellular origin and tissue heterogeneity in bipolar disorder (BD) by integrating multiomics data. Four distinct datasets were employed, including single-cell RNA sequencing (scRNA-seq) data (embryonic fetal brain, n = 8, 1,266 cells), BD Assay for Transposase-Accessible Chromatin using (ATAC-seq) (adult 210), bulk RNA-seq 314), genome-wide association (GWAS) summary (n 413,466). The integration of scRNA-seq with relevant to was accomplished disease relevance score...
Objective To investigate the effects of mild insufficient iodine intake on thyroid function and autoantibodies in pregnant women, to provide a basis for scientific supplementation women. Methods From December 2015 March 2016, Suixi County Guangdong Province was selected as survey site, Lechang City control local women 8 10 years old students were study subjects. Urinary iodine, 5 woman tested: thyrotropin (TSH) free thyroxine (FT4), triiodothyronine (FT3), anti-thyroid peroxidase...
Objective To assess the relationship between serum vitamin D level and metabolic/endocrine disorders in women with polycystic ovary syndrome (PCOS). Methods The clinical studies about PCOS were undertaken through popular English Chinese databases until May 2017. Two authors independently screened studies, extracted data evaluated study quality. Data analyses conducted by RevMan5.3. Results Thirty included. Meta-analysis showed of was lower (SMD=-1.16, 95% CI=-1.84--0.49,...