A5101590658- Autophagy in Disease and Therapy
- Platelet Disorders and Treatments
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Treatment and Research
- Berberine and alkaloids research
- Ferroptosis and cancer prognosis
- Autoimmune Bullous Skin Diseases
- Synthesis and biological activity
- Oral microbiology and periodontitis research
- Cytomegalovirus and herpesvirus research
- Liver physiology and pathology
- PI3K/AKT/mTOR signaling in cancer
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Drug-Induced Ocular Toxicity
- Heparin-Induced Thrombocytopenia and Thrombosis
- Complement system in diseases
- Adipose Tissue and Metabolism
Army Medical University
2013-2025
Fujian Medical University
2024
Anhui Medical University
2009-2024
Henan University
2024
Kaifeng University
2024
First Affiliated Hospital of Anhui Medical University
2009-2024
First Affiliated Hospital of Henan University
2024
Fourth Affiliated Hospital of Anhui Medical University
2020-2022
Army Medical College
2020
Multiple Myeloma Research Foundation
2020
Immune thrombocytopenia (ITP) is characterized by platelet clearance mediated primarily autoantibodies against the GPIIbIIIa and/or GPIbα. Steroid therapy a first-line treatment for ITP. However, some patients are refractory to this and currently no method can predict which will respond. To evaluate whether steroids equally efficacious in treating with ITP caused anti-GPIIbIIIa versus anti-GPIbα antibodies, we performed retrospective study on 176 newly diagnosed acute who had severe bleeding...
Eukaryotes initiate autophagy when facing environmental changes such as a lack of external nutrients. However, the mechanisms initiation are still not fully elucidated. Here, we showed that deacetylation ATG4B plays key role in starvation-induced initiation. Specifically, demonstrated is activated during starvation through at K39 by deacetylase SIRT2. Moreover, triggers SIRT2 dephosphorylation and activation cyclin E/CDK2 suppression–dependent manner. Meanwhile, down-regulates p300, leading...
Macroautophagy/autophagy-mediated anoikis resistance is crucial for tumor metastasis. As a key autophagy-related protein, ATG4B has been demonstrated to be prospective anti-tumor target. However, the existing inhibitors are still far from clinical application, especially In this study, we identified novel circRNA, circSPECC1, that interacted with ATG4B. CircSPECC1 facilitated liquid-liquid phase separation of ATG4B, which boosted ubiquitination and degradation in gastric cancer (GC) cells....
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), key in chaperone-mediated autophagy (CMA) pathway, is elevated breast tumor tissues. However, exact effects and mechanisms CMA during cancer metastasis remain largely unknown. In this study, we found LAMP2A level was significantly human tissues, particularly metastatic carcinoma. The increased also positively correlated with histologic grade ductal cancer. High levels predicted shorter...
Interferon regulatory factor-4 binding protein (IBP) is a novel upstream activator of Rho GTPases. Our previous studies have shown that ectopic expression IBP was correlated with malignant behaviors human breast cancer cells, and invasive had high promoted the proliferation these cells. However, it remains unknown whether autophagy inhibition contributes to IBP-mediated tumorigenesis. In this study, we for first time, reported upregulation significantly suppressed downregulation markedly...
Human DNA polymerase iota (pol ι) possesses high error-prone replication features and performs translesion synthesis. It may be specialized strictly regulated in normal mammalian cells. Dysregulation of pol ι contribute to the acquisition a mutator phenotype. However, there are few reports describing transcription regulatory mechanism ι, is controversy regarding its role carcinogenesis. In this study, we performed deletion point-mutation experiment, EMSA, ChIP, RNA interference western blot...
Evidence shows that chaperone-mediated autophagy (CMA) is involved in cancer cell pathogenesis and progression. However, the potential role of CMA breast angiogenesis remains unknown. We first manipulated activity by knockdown overexpressing lysosome-associated membrane protein type 2A (LAMP2A) MDA-MB-231, MDA-MB-436, T47D MCF7 cells. found tube formation, migration proliferation abilities human umbilical vein endothelial cells (HUVECs) were inhibited after cocultured with tumor-conditioned...
Abstract Background The study explores an innovative teaching mode that integrates Icourse, DingTalk, and online experimental simulation platforms to provide theoretical resources for clinical biochemistry practical courses. These platforms, combined with flipped classroom teaching, aim increase student engagement benefit in courses, ultimately improving the effectiveness of teaching. Methods In a prospective cohort study, we examined impact integrating Icourse DingTalk knowledge cases 48...
Background: Sorafenib is the first-line therapy for patients with advanced-stage HCC, but its clinical cure rate unsatisfactory due to adverse reactions and drug resistance. Novel alternative strategies overcome sorafenib resistance are urgently needed. Oxyberberine (OBB), a major metabolite of berberine in vivo, exhibits potential antitumor potency various human malignancies, including liver cancer. However, it remains unknown whether how OBB sensitizes cancer cells sorafenib. Methods: Cell...
The activation of ferroptosis presents a versatile strategy for enhancing the antitumor immune responses in cancer therapy. However, developing inducers that combine high biocompatibility and therapeutic efficiency remains challenging. In this study, we propose novel approach using biological nanoparticles derived from outer membrane vesicles (OMVs) Escherichia coli tumor treatment, aiming to activate stimulate responses. Specifically, functionalize OMVs by anchoring them with ferrous ions...
We aimed to investigate the expression of interleukin 12 (IL-12) family cytokines (IL-12, IL-23, IL-27 and IL-35) their relevant (IFN-γ, IL-4, IL-17A IL-10) in patients with chronic immune thrombocytopenia (cITP) as well effect high-dose dexamethasone (HD-DXM) treatment on this expression.DXM was administered orally at a dose 40 mg per day for 4 consecutive days 38 cITP. measured plasma levels IL-12p70, IL-27, IFN-γ, IL-4 before after also 36 matched healthy controls, by means FlowCytomix™...
Bortezomib is a novel proteasome inhibitor, which has been successfully used to treat mantle cell lymphoma and multiple myeloma. However, the direct effects of bortezomib on acute promyelocytic leukaemia (APL) have not fully investigated. In present study, WST‑8 assay, western blotting, flow cytometry, monodansylcadaverine staining transmission electron microscopy were performed. It was demonstrated that treatment induced time‑ dose‑dependent decrease in viability NB4 cells. apoptosis cells,...
Tyrosine kinase inhibitors are increasingly used to treat chronic myeloid leukemia (CML), but loss of complete cytogenetic response (CCyR) indicates treatment failure.To compare the efficacy Sokal, European Treatment Outcome Study (EUTOS), and Hasford prognostic scores with 3-month 12-month CCyR, event-free survival (EFS) progression-free (PFS) in patients chronic-phase CML (CP-CML) undergoing imatinib therapy.We retrospectively analyzed outcome 210 CP-CML treated at First Affiliated...
To investigate the predictive value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte (PLR) for patients with diffuse large B-cell lymphoma (DLBCL).The clinical data 57 DLBCL admitted in First Affiliated hospital Anhui Medical University were analyzed retrospectively. According to ROC curve, cut-off NLR PLR was deterimined, divided into high low NLR/PLR groups before first chamotherapy. Then relation overall survival (OS) progression-free (PFS) by univariate multivariate COX...
Tumor lysis syndrome (TLS) is an oncologic emergency, but its incidence in MM rare. To our knowledge, ixazomib has not been associated with TLS MM.The patient developed after 10 days of treatment ixazomib, accompanied by renal failure hyperuricemia, hyperkalemia, and hyperphosphatemia.MM (type IgG λ) was diagnosed according to the diagnostic criteria established International Myeloma Working Group classified stage IIA Staging System. met all three Cairo-Bishop scoring system.From April 8,...
Patients with leukemia rely on social and family support. This study aimed to explore the knowledge, attitude, practice (KAP) toward among members of patients general population in southeast China.