A5100737952- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- HIV Research and Treatment
- Liver Disease and Transplantation
- Gestational Diabetes Research and Management
- Nitric Oxide and Endothelin Effects
- Enhanced Recovery After Surgery
- Biochemical effects in animals
- Cardiac Ischemia and Reperfusion
- Hepatitis B Virus Studies
- Endometrial and Cervical Cancer Treatments
- Supramolecular Chemistry and Complexes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Metal complexes synthesis and properties
- Adipose Tissue and Metabolism
Sichuan University
2025
West China Hospital of Sichuan University
2025
Beijing Friendship Hospital
2017-2024
Capital Medical University
2017-2024
National Clinical Research Center for Digestive Diseases
2017-2024
Qilu Hospital of Shandong University
2023
Shandong University
2023
University of Amsterdam
2022-2023
Amsterdam University Medical Centers
2022-2023
Sun Yat-sen University
2010-2021
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), key in chaperone-mediated autophagy (CMA) pathway, is elevated breast tumor tissues. However, exact effects and mechanisms CMA during cancer metastasis remain largely unknown. In this study, we found LAMP2A level was significantly human tissues, particularly metastatic carcinoma. The increased also positively correlated with histologic grade ductal cancer. High levels predicted shorter...
Human immunodeficiency virus (HIV) self-testing serves as a crucial strategy for overcoming testing barriers, with urine-based emerging potential novel approach. In real-world setting, this study demonstrated that the urine rapid test exhibited lower diagnostic accuracy compared to blood test. Study participants expressed stronger preferences HIV methods utilizing finger prick samples, accompanied by standard written instructions and costs. Our findings indicate requires additional...
In 2015, the Chinese Society of Hepatology and Gastroenterology published a consensus on primary biliary cholangitis (PBC). past years, numerous clinical studies have been in field PBC. To guide diagnosis management PBC patients, invited panel experts to assess new evidence formulate current guidelines.
Abstract Background and Aim The impact of male sex past hepatitis B virus (HBV) infection on survival primary biliary cholangitis (PBC) are issues at discussion. aim the present study was to identify risk factors for transplant‐free (TRS) in Chinese PBC patients who received ursodeoxycholic acid (UDCA), with special focus HBV infection. Methods We followed up UDCA our institute between January 2000 December 2017 until their death, liver transplantation, or censored April 1, 2018, by...
The diagnostic value of antinuclear antibodies (ANAs) including anti-gp210 and anti-sp100 for primary biliary cholangitis/cirrhosis (PBC) has been widely reported. However, their performances antimitochondrial antibody- (AMA-) negative PBC were less well elucidated. Therefore, the aim current meta-analysis was to evaluate accuracy ANAs in patients with AMA-negative PBC. Literature on biomarkers systematically searched PubMed, MEDLINE, EMBASE, Cochrane Library. qualities retrieved studies...
The metabolic score for insulin resistance (METS-IR) is a simple, convenient, and reliable marker (IR), which has been regarded as predictor of cardiovascular disease (CVD) events. However, few studies examined the relationship between METS-IR prognosis after coronary artery bypass graft (CABG). This study aimed to investigate potential value prognostic indicator major adverse events (MACE) in patients CABG.
Cardiac microvascular injury often occurs in patients with type 2 diabetes mellitus (T2DM) who develop hyperglycemia and hyperlipidemia. However, besides reported contradictory roles cardiac diseases, the function of TRPV1 (transient receptor potential vanilloid 1) microvessels is not well defined. This study was performed to determine detailed role endothelial cells (CMECs) T2DM. T2DM mice were established by multiple injections low-dose streptozotocin high-fat feeding. CMECs cultured...
Abstract Background HIV testing is an essential gateway to prevention and treatment thus controlling the epidemic. More innovative interventions are needed increase among men who have sex with (MSM) since their rate still low. We proposed online test results exchange mechanism whereby one without a certified report will be asked for exchanging others. The developed as extension existing service system. Through extended system, MSM can obtain reports friends via WeChat. This study aims assess...
Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in isolated ventricular cardiomyocytes (CMs). However, other studies with have yielded conflicting results. This may be explained by methodological factors including cell isolation techniques, types and ambient pH. In this study, we tested whether use of protease XIV (PXIV) abrogate inhibition on NHE1 activity rabbit CMs or rat cardiomyoblast cells (H9c2), a pH dependent manner. Methods: Rabbit were...
Abstract To evaluate the application of multiple b values diffusion-weighted imaging based on biexponential signal decay model to predict response concurrent chemoradiotherapy in cervical cancer patients. This prospective study enrolled 28 patients (mean age: 50.89 ± 10.70 years) with confirmed by biopsy who received chemoradiotherapy. Pelvic magnetic resonance scans were performed 2 weeks before, 7 days and 21 after initiation therapy, 1 month end treatment. Diffusion-weighted 0, 50, 450,...
Abstract Background & Aims Double‐negative (DN) T‐cell is a unique regulatory T‐cell, which essential for maintaining immune system homoeostasis. However, the role of DN T‐cells in pathogenesis primary biliary cholangitis (PBC) still unknown. Methods We investigated number and function peripheral blood liver biopsy specimens PBC patients. Results The frequency significantly decreased tissue Furthermore, was negatively correlated with disease severity positively ursodeoxycholic acid...
Abstract Anti‐mitochondrial autoantibodies (AMAs) are highly specific for the diagnosis of primary biliary cholangitis (PBC) but also occasionally found in other diseases. In present study, we evaluated incidence and predictors PBC development AMA‐positive patients with liver or non‐liver diseases at baseline. this retrospective screened who tested positive AMA and/or anti‐mitochondrial M2 antibody (AMA‐M2) Beijing Friendship Hospital, Capital Medical University, from October 2005 to January...
Primary biliary cholangitis (PBC) with early cholestasis and extensive bile duct loss but no significant fibrosis or cirrhosis is rare underrecognized. We aimed to clarify the clinicopathology features prognosis of these variants patients early-stage PBC ductopenia. From January 2009 2023, we retrospectively collected laboratory pathologic data recorded their liver-related events a median follow-up 4.5 years. Finally, total 141 in stage were included divided into 2 groups: one ductopenia (n...
Background: Mildly elevated levels of transaminase and/or immunoglobulin G (IgG) are common in patients with primary biliary cholangitis (PBC). It is still unclear whether adding immunosuppressive therapy to ursodeoxycholic acid (UDCA) benefits those who not fulfilling the diagnostic criteria PBC autoimmune hepatitis (AIH) features. Objectives: To assess efficacy UDCA for and phenomena but AIH Design: This a retrospective–prospective cohort study tertiary medical center. Methods: Patients...