A5103931989- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Cancer-related molecular mechanisms research
- Phytochemical compounds biological activities
- Oral microbiology and periodontitis research
- Stroke Rehabilitation and Recovery
- Cancer-related gene regulation
- Birth, Development, and Health
- Antimicrobial Peptides and Activities
- S100 Proteins and Annexins
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Artificial Intelligence in Healthcare and Education
- Adenosine and Purinergic Signaling
- Plasma Applications and Diagnostics
- Hematopoietic Stem Cell Transplantation
Shandong Provincial Hospital
2024-2025
Shandong First Medical University
2024-2025
University of Massachusetts Chan Medical School
2023-2025
Chinese Academy of Sciences
2018-2025
Shanghai Institute of Organic Chemistry
2018-2025
Chongqing Cancer Hospital
2023-2025
Chongqing University
2023-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
China Medical University
2014-2024
North China University of Science and Technology
2024
Cellular senescence, characterized by stable cell cycle arrest, plays an important role in aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged tissues ameliorates diseases. Here, we identified that natural killer group 2 member D ligands (NKG2DLs) are up-regulated vitro, regardless of stimuli induced cellular various mice nonhuman primates vivo. Accordingly, developed demonstrated chimeric antigen receptor (CAR) T targeting human NKG2DLs selectively effectively...
Vessel loss precipitates many diseases. In particular, vessel resulting in hypoxia induces retinal neovascularization diabetic retinopathy and of prematurity (ROP), major causes blindness. Here we define insulin-like growth factor binding protein-3 (IGFBP3) as a new modulator vascular survival regrowth oxygen-induced retinopathy. IGFBP3-deficient mice, there was dose-dependent increase loss. Subsequent to loss, Igfbp3(-/-) mice had 31% decrease versus controls after returning room air. No...
Abstract The rising prevalence of global antibiotic resistance evokes the urgent need for novel antimicrobial candidates. Cationic lipopeptides have attracted much attention due to their strong activity, broad‐spectrum and low tendency. Herein, a library fluoro‐lipopeptide amphiphiles was synthesized by tagging series cationic oligopeptides with fluoroalkyl tail via disulfide spacer. Among lipopeptide candidates, R6F bearing six arginine moieties fluorous tag shows highest antibacterial it...
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The receptor tyrosine kinases TAM family (TYRO3, AXL, and MERTK) are highly expressed in multiple forms of cancer cells tumor-associated macrophages promote the development cancers including pancreatic tumor. Targeting receptors could be a promising therapeutic option.We designed novel CAR based on extracellular domain growth arrest-specific protein 6 (GAS6), natural ligand for all members. ability CAR-T to kill is tested vitro vivo, safety evaluated mice nonhuman primate.GAS6-CAR-T...
The clinical applications of immunocytokines are severely restricted by dose-limiting toxicities. To address this challenge, here we propose a next-generation immunocytokine concept involving the design LH05, tumor-conditional anti-PD-L1/interleukin-15 (IL-15) prodrug. LH05 innovatively masks IL-15 with steric hindrance, mitigating "cytokine sink" effect and reducing systemic toxicities associated wild-type anti-PD-L1/IL-15. Moreover, upon specific proteolytic cleavage within tumor...
Abstract The robust and stable expression of CD38 in T‐cell acute lymphoblastic leukemia (T‐ALL) blasts makes chimeric antigen receptor (CAR)‐T/natural killer (NK) a potential therapy for T‐ALL. However, normal T/NK cells causes fratricide CAR‐T/NK cells. Here “2‐in‐1” gene editing strategy is developed to generate fratricide‐resistant locus‐specific CD38‐specific CAR integrated into the disrupted locus by CRISPR/Cas9, placed under control either endogenous promoter ( KO/KI ) or exogenous...
Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological malignancies, but faces many challenges in tumors. One major challenge the shortage of tumor-selective targets. Cell surface GRP78 (csGRP78) expressed on various cells including pancreatic cancer, not normal cells, providing potential target for CAR-T cancer. Here, we demonstrated that csGRP78-directed...
ABSTRACT Background [18F] AlF-NOTA-FAPI-04 is a novel positron emission tomography (PET) ligand, which specifically targets fibroblast activation protein (FAP) expression as FAP inhibitor (FAPI). We analysed the diagnostic value of PET/CT for non-invasive assessment kidney interstitial inflammation and fibrosis in different renal pathologies. Methods Twenty-six patients (14 males 12 females; mean age, 50.5 ± 16.5 years) with wide range diseases 10 (six four 55.4 8.6 without known evidence...
Posttraumatic elbow stiffness is a complex complication with two characteristics of capsular contracture and heterotopic ossification. Currently, genomic mechanisms pathogenesis posttraumatic remain inadequately understood. This study aims to identify differentially expressed genes (DEGs) elucidate molecular networks stiffness, providing novel insights into disease at transcriptome level. Global sequencing was conducted on six samples from individuals three control fractures. Differentially...
657 Background: SHR-A2102 is a novel ADC that consists of fully humanized IgG1 monoclonal antibody targeting nectin-4, cleavable linker, and topoisomerase I inhibitor payload with high membrane permeability potent cell-killing efficacy. We have initiated first-in-human phase 1 study to assess the safety, tolerability, efficacy in advanced solid tumors. Here, we present preliminary findings, focusing on urothelial carcinoma. Methods: Patients (pts) locally unresectable or metastatic...
ABSTRACT AAV capsid serotypes isolated from nature have been widely used in gene delivery and therapy. Recently, more than 1,000 distinct capsids were identified human clinical samples by high-throughput, long-read DNA sequencing (Hsu HL et al. Nature Communications 2020). In this study, we tap into broad natural biodiversity of to develop liver-tropic capsids. We initially screened a subset variants derived AAV8 (n=159) for packaging efficiency. The top 30% these subjected barcoded vector...
Traditional transrectal ultrasound (TRUS)-guided prostate biopsy has limited sensitivity and specificity, particularly for detecting early-stage cancer, due to a lack of precise lesion targeting. An improved cognitive fusion-guided method been developed enhance targeting by integrating three parameters multiparametric MR (mpMRI) images into TRUS images. Prostate mpMRI measurement is initially performed obtain key parameters: the rotation angle (α), distance from rectal wall (X), apex (Y)....
Abstract Fibroblast activation protein (FAP) is overexpressed on cancer-related fibroblasts (CAFs), making it an important target for cancer diagnosis and treatment, but limited tumor retention hinders late-stage radionuclide therapy. In this study, three albumin-bound FAPI radioligands, 68Ga/177Lu-DOTA-ALB-01, 68Ga/177Lu-DOTA-ALB-02, 68Ga/177Lu-DOTA-ALB-03, were synthesized evaluated their in vitro stability, binding affinity, vivo biodistribution, uptake using 68Ga 177Lu labeling. All...
Despite therapeutic benefits of anti-Programmed Death-Ligand 1 (PD-L1) therapy in triple-negative breast cancer (TNBC), low response rates and resistance limit its efficacy. Both manganese (Mn) bisphosphonates (BPs) are known to induce immunogenic cell death (ICD). Strategies synergistically enhance ICD induction elucidate the underlying molecular mechanisms remain be fully explored. We analyzed mode apoptosis immunogenicity cells post-treatment using Western blotting, flow cytometry,...
Gene therapy using recombinant adeno-associated virus (rAAV) relies on safe, efficient, and precise in vivo gene delivery that is largely dependent the AAV capsid. The proteinaceous capsid highly amenable to engineering a variety of approaches, most resulting capsids carry substitutions or insertions comprised natural amino acids. Here, we incorporated non-canonical acid (ncAA), Nε-2-azideoethyloxycarbonyl-L-lysine (also known as NAEK), into AAV5 genetic code expansion, serendipitously found...
The photocatalytic activity of g-CN directly correlates with its production yield, which is controlled by the polymerization kinetics and thus sensitive to synthesis conditions. synthesis–structure–property relationship has been discussed.
Background: Cognitive biases in clinical decision-making significantly contribute to errors diagnosis and suboptimal patient outcomes. Addressing these presents a formidable challenge the medical field. This study explores role of large language models (LLMs) mitigating through utilization multi-agent framework. We simulate processes conversation evaluate its efficacy improving diagnostic accuracy. Methods: A total 16 published unpublished case reports where cognitive have resulted...