A5091806674- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Acute Ischemic Stroke Management
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Traumatic Brain Injury and Neurovascular Disturbances
- CRISPR and Genetic Engineering
- Esophageal Cancer Research and Treatment
- Advanced Neuroimaging Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Cancer Studies
- Advanced MRI Techniques and Applications
- T-cell and B-cell Immunology
- Brain Metastases and Treatment
- Medical Imaging and Analysis
- Nanowire Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
Guangzhou Medical University
2025
Zhejiang University
2020-2025
First Affiliated Hospital Zhejiang University
2021-2025
Qingdao University
2023-2024
Guiyang Medical University
2024
Taian City Central Hospital
2017-2024
Shanghai Sixth People's Hospital
2019-2024
Shanghai Jiao Tong University
2019-2024
Luoyang Central Hospital Affiliated to Zhengzhou University
2024
First Affiliated Hospital of Nanchang University
2021-2022
Abstract The robust and stable expression of CD38 in T‐cell acute lymphoblastic leukemia (T‐ALL) blasts makes chimeric antigen receptor (CAR)‐T/natural killer (NK) a potential therapy for T‐ALL. However, normal T/NK cells causes fratricide CAR‐T/NK cells. Here “2‐in‐1” gene editing strategy is developed to generate fratricide‐resistant locus‐specific CD38‐specific CAR integrated into the disrupted locus by CRISPR/Cas9, placed under control either endogenous promoter ( KO/KI ) or exogenous...
Abstract Some cancers are strongly associated with exposure to environmental carcinogens, and genetic epigenetic alterations crucial in carcinogenesis. However, the interaction between mutations regulation cancer development has not been sufficiently examined. Here, we investigated roles of gene altered circRNA expression malignant transformation human bronchial epithelial cells after continuous CdCl2 (10 μM). The circular RNA circ_0007095 was down-regulated, SETBP1-R54P single nucleotide...
Abstract T cell genome editing holds great promise to advance a range of immunotherapies but is encumbered by the dependence on difficult‐to‐produce and expensive viral vectors. Here, small double‐stranded plasmid DNA modified mediate high‐efficiency homologous recombination designed. The resulting chimeric antigen receptor (CAR)‐T cells display similar phenotype, transcriptional profile, in vivo potency CAR‐T generated using adeno‐associated vector. This method should simplify accelerate...
Abstract To investigate the value of artificial intelligence (AI) assisted quantification on initial chest CT for prediction disease progression and clinical outcome in patients with coronavirus 2019 (COVID-19). Patients confirmed COVID-19 infection initially non-severe type were retrospectively included. The scan admission was used imaging analysis. presence ground glass opacity (GGO), consolidation other findings visually evaluated. severity score calculated according to extent lesion...
Purpose This study aimed to evaluate 5-year outcomes and the late toxicity profile of chrono-chemotherapy with different infusion rates in patients locally advanced nasopharyngeal carcinoma (NPC). Methods materials Our retrospective analysis included 70 NPC stages III IVB (according 2010 American Joint Committee on Cancer staging system). Patients were treated two cycles induction chemotherapy (IC) before concurrent chemoradiotherapy (CCRT) at Guizhou Hospital. The IC docetaxel, cisplatin...
CD19-targeting chimeric antigen receptors (CARs) with CD28 and CD3ζ signaling domains have been approved by the US FDA for treating B cell malignancies. Mutation of immunoreceptor tyrosine-based activation motifs (ITAMs) in generated a single-ITAM containing 1XX CAR, which displayed superior antitumor activity leukemia mouse model. Here, we investigated whether design could enhance therapeutic potency against solid tumors. We constructed both CD19- AXL-specific CARs compared their vitro vivo...
Background and Purpose: Remote white matter cortex reorganization may contribute to functional clinical outcome after acute infarcts. To determine the microstructural changes in remote intact corticospinal tract (CST) precentral gyrus connected infarct subcortical stroke involving CST over 6 months. Methods: Twenty-two patients with underwent magnetic resonance imaging (MRI) assessment phase (baseline) months (follow-up) stroke. The MRI sequences included T1-weighted imaging, T2-weighted...
Objective: Granulocyte colony-stimulating factor (G-CSF) is the critical regulator of proliferation, differentiation, and survival granulocytes. Recently, it has been shown that G-CSF can adversely affect bone health in both animal models patients. Here, authors aimed to investigate whether could inhibit growth osteoblasts osteocytes by regulating nitric oxide. Methods: The C57BL/6 mice were divided into control group, treatment group recovery (G-CSF+L-NAME). morphology femurs was assessed...
Abstract Background RPL35A has been reported to work as a biomarker in tumor angiogenesis. However, little performed on the expression level and functional importance of gastric cancer (GC). Methods The protein was detected by immunohistochemical staining western blot analysis. Celigo cell counting assay used assess proliferation. Both wound healing transwell were conducted evaluate migration. Flow cytometric analysis utilized detect apoptosis cycle. A mouse xenograft model constructed for...
Lenvatinib, regorafenib and anti-programmed cell death protein-1 (PD-1) immunotherapy have shown promising clinical outcomes in patients with advanced hepatocellular carcinoma (HCC) after sorafenib failure, respectively. However, the combination of two treatments has not been reported. We compared efficacy PD-1 inhibitors lenvatinib (PL) plus (PR) HCC this study.We conducted a retrospective study who undergone combined or failure at Second Affiliated Hospital Nanchang University from July...
The Nod-like receptor (NLR) family CARD domain containing 5 (NLRC5) has been reported as an activator of human leukocyte antigen (HLA) class I that is responsible for immune activity in cancer treatment. This work focuses on the role BMI1 proto-oncogene (BMI1) NLRC5-HLA axis and escape non-small cell lung (NSCLC). First, immunoblot analysis and/or reverse transcription-quantitative polymerase chain reaction were performed, which identified decreased NLRC5 HLA levels NSCLC tissues lines....
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with cytotoxic chemotherapy are highly effective in the treatment of advanced non-small-cell lung cancer (NSCLC) EGFR mutations. The purpose this study is to evaluate efficacy and safety combination NSCLC patients an EGFR/TP53 co-mutation.Ninety-five co-mutation were enrolled study. Treatments either EGFR-TKI monotherapy (T group, n = 61) or (TC 34) evaluated relation objective response rate (ORR), disease...
This experiment aimed to explore the curative effect of Tuling Wendan Decoction combined with flunarizine on migraine patients and intervention serum cyclooxygenase-2 (COX-2), endothelin-1 (ET-1), nitric oxide(NO) levels. For this purpose, from January 2019 2020, 96 in our hospital were selected as research object. Using a simple randomization method, who meet criteria assigned 1:1, each patient was random number, which number 1 48 observation group, 49 control group. The group treated...
Introduction. In clinical settings, nodular projection (NP) and cord sign (CS) at the tumor edge irregular nodules (IN) in mesorectum often appeared together with extramural vascular invasion (EMVI). We aim to evaluate diagnostic efficiency of MRI morphology primary predicting EMVI patients rectal cancer (RC). Methods. This retrospective study included 156 RC. Clinical imaging factors including NP tumor’s edge, CS maximal depth (EMD), IN mesorectum, growth pattern, length, range wall invaded...
This study aimed to investigate the correlation between baseline MRI features and carcinoembryonic antigen (CEA) expression status in rectal cancer patients. A training cohort of 168 patients from Center 1 an external validation 75 2 were collected. nomogram was constructed based on validated using predict high CEA The nomogram's discriminative ability clinical utility tested receiver operating characteristic (ROC) curve, decision curve analysis (DCA). high-expression group had significantly...
e18003 Background: This study aimed to evaluate 5-year outcomes and the late toxicity profile of chrono-chemotherapy with different infusion rates in patients locally advanced nasopharyngeal carcinoma (NPC). Methods: Our retrospective analysis included 70 NPC stages III IVB (according 2010 American Joint Committee on Cancer staging system). Patients were treated two cycles induction chemotherapy (IC) before concurrent chemoradiotherapy (CCRT) at affiliated cancer hospital Guizhou medical...
Many cancers exhibit resistance to chemotherapy, resulting in a poor prognosis. The transcription factor NRF2, activated response cellular antioxidants, plays crucial role cell survival, proliferation, and chemotherapy. This may serve as promising target for therapeutic interventions esophageal carcinoma. Recent research suggests that NRF2 activity is modulated by ubiquitination mediated the KEAP1-CUL3 E3 ligase complex, highlighting importance of deubiquitination. However, specific...
Objective: To investigate the effects of nimotuzumab on radiosensitivity ECA-109 and TE-13 esophageal carcinoma cell lines explore its possible mechanism. Methods: The cells were divided into control group, irradiation medicine combined group (irradiation + medicine). In treated with for 24 h before irradiation, collected 2 after irradiation. radiosensitizing evaluated by clone formation assay. Cell apoptosis was detected flow cytometry. Western blotting used to evaluate expression EGFR,...
Purpose: In premise of uninfluenced to dose distribution tumor target and organ at risk(OAR) in cervical cancer,area segment fields was changed increase efficacy optimize treatment method by designing different plan intensity modulated radiotherapy(IMRT). Methods: 12 cases cancer were confirmed pathology treated with step shoot IMRT. Dose PTV 50Gy/25fractions. Every patient designed 9 plans IMRT Pinnacle 8.0m planning system,each used beams uniform fixing incidence...