A5073251884- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Atherosclerosis and Cardiovascular Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Hematopoietic Stem Cell Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
- Pregnancy-related medical research
- Gut microbiota and health
- Reproductive Biology and Fertility
- Clostridium difficile and Clostridium perfringens research
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Helicobacter pylori-related gastroenterology studies
Sichuan University
2023-2025
West China Second University Hospital of Sichuan University
2023-2025
First Affiliated Hospital Zhejiang University
2019-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2020-2024
Ministry of Education
2024
Fujian Agriculture and Forestry University
2024
Sun Yat-sen University
2012-2024
The First Affiliated Hospital, Sun Yat-sen University
2012-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Zhejiang University
2019-2023
The early diagnosis of hepatocellular carcinoma (HCC) can greatly improve patients' 5-year survival rate, and the efficacy assessment is important for oncologists to harness anti-programmed cell death protein 1 (PD-1) immunotherapy in patients with advanced HCC. lack effective predicting biomarkers not only leads delayed detection disease but also results ineffective limited clinical benefit.We exploited single-cell approach (cytometry by time flight (CyTOF)) analyze peripheral blood...
Abstract Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation lipid contents and chronic inflammation. Traditional strategies primarily focus on reduction to control AS progression, leaving residual inflammatory risks for major adverse cardiovascular events (MACEs). While anti-inflammatory therapies targeting innate immunity have reduced MACEs, many patients continue face significant risks. Another key component in progression...
Objectives Varicella-zoster virus (VZV) can induce herpes zoster (HZ) and postherpetic neuralgia (PHN). Immune cells play an important role in regulating HZ PHN pathogenesis, but the dynamic immune profiles molecular mechanisms remain unclear. This study aimed to screen signatures during progression elucidate mechanism of VZV-specific T PHN. Methods We used cytometry by time-of-flight (CyTOF) analyze peripheral blood mononuclear (PBMC) samples from 45 patients with eight age-sex-matched...
The efficacy of mesenchymal stem cell (MSC)-based therapy for acute liver injury (ALI) involves coordination with the hepatic immune system, a complex and coordinated network immune-cell interactions. However, studies immunomodulatory effects MSCs have focused on limited number subsets rather than systematic assessment. Carbon tetrachloride (CCl4) was used to induce ALI in mice. To determine MSCs, mice were injected via tail vein, histopathological changes, survival rate, serum levels...
Abstract T cell genome editing holds great promise to advance a range of immunotherapies but is encumbered by the dependence on difficult‐to‐produce and expensive viral vectors. Here, small double‐stranded plasmid DNA modified mediate high‐efficiency homologous recombination designed. The resulting chimeric antigen receptor (CAR)‐T cells display similar phenotype, transcriptional profile, in vivo potency CAR‐T generated using adeno‐associated vector. This method should simplify accelerate...
Abstract Chimeric antigen receptor (CAR)-T therapy requires autologous T lymphocytes from cancer patients, a process that is both costly and complex. Universal CAR-T cell treatment allogeneic sources can overcome this limitation but impeded by graft-versus-host disease (GvHD) host versus-graft rejection (HvGR). Here, we introduce mutated calcineurin subunit A (CNA) CD19-specific CAR into the α constant ( TRAC ) locus to generate cells are resistant widely used immunosuppressant, cyclosporine...
Objective This study aimed to investigate the relationship between pregnancy stress and mental health of pregnant women, employing a positive psychology perspective. Specifically, sought explore how two psychological qualities mindfulness peace mind may serve as potential mediators in association women. Methods Seven hundreds thirteen women seeking care at First Affiliated Hospital Sun Yat-Sen University were included this study. The participants completed self-report demographic...
Abstract Immune checkpoint blockade (ICB) treatment of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection may activate viral-specific T cells to attack HBV infected hepatocytes and thus induce immune-related liver injury. Therefore, it is important deeply understand the impacts on HCC immune microenvironment in order better design effective immunotherapies for + (HBV infected) patients. Here, We performed cytometry by time-of-flight (CyTOF) analyses characterize...
Single-cell multiplexing is key to exploration of the heterogeneous cell populations in biological systems. Although state-of-the-art mass cytometry (CyTOF) possesses high resolution and multiple dimensions, lack suitable marker materials prohibits fully exploiting available CyTOF detection channels. Here we report a new design strategy for markers using functionalized mesoporous porphyrinic frameworks (MPFs) as scaffolds chelating metals that have been unachievable by conventional...
Purpose To compare the effects of recombinant FSH alfa (rFSH-alfa), rFSH-beta, highly purified human menopausal gonadotropin (HP-hMG) and urinary (uFSH) in women with polycystic ovarian syndrome who have undertaken GnRH antagonist protocol during IVF/ICSI treatment. Method A single-center retrospective cohort study including PCOS received from January 2019 to July 2022 was conducted. Patients were divided into rFSH-alfa group, HP-hMG uFSH rFSH-beta number oocytes retrieved, clinical...
Abstract Immune checkpoint inhibitors have transformed the treatment landscape of non-small cell lung cancer (NSCLC). However, accurately identifying patients who will benefit from immunotherapy remains a challenge. This study aimed to discover potential biomarkers for predicting response in NSCLC patients. Single-cell mass cytometry (CyTOF) was utilized analyze immune subsets peripheral blood mononuclear cells (PBMCs) obtained before and 12 weeks after single-agent immunotherapy. The CyTOF...
Present study was to evaluate whether increased arterial stiffness associated with target organ damage in pre-hypertensive subjects.Pre-hypertensive subjects enrolled and echocardiography used left ventricular hypertrophy (LVH) the first morning urine collected albumin creatinine ratio (ALB/Cr ratio). Carotid-femoral pulse wave velocity (cf-PWV) measured.A total of 420 were recruited mean age 42.6 years. Mean systolic/diastolic blood pressure (SBP/DBP) 130 ±9 mm Hg 85 ±4 Hg. The prevalence...
Background Current stratification systems for tumor prognostic prediction and immunotherapeutic efficacy evaluation are less satisfying in colorectal cancer (CRC). As infiltrating immune cells microenvironment (TME) played a key role progression responses to checkpoint blockade (ICB) therapy, we want construct an immune-related scoring system with detailed profiles stratify CRC patients. Methods We developed based on signatures validated its ability predict prognosis outcomes CRC. CD45 +...
To investigate the influence of quality life (QOL) on unhealthy emotions as well relevant factors among patients with endometriosis for supporting clinical care.A convenience sampling method was used to administer questionnaires 139 endometriosis, using Hamilton Anxiety Inventory (HAMA), Depression Scale (SDS), and SF-12 Health Survey Short Form, results were analyzed. The SPSS20.0 software statistical analysis data. If P < 0.05, there significance.Twelve-Item Form (SF-12) health survey...