A5102865102- CAR-T cell therapy research
- Bone fractures and treatments
- Hip and Femur Fractures
- Surgical site infection prevention
- Trauma and Emergency Care Studies
- CRISPR and Genetic Engineering
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- T-cell and B-cell Immunology
- Nutrition and Health in Aging
- Antibiotics Pharmacokinetics and Efficacy
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Nanowire Synthesis and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- Cardiovascular and Diving-Related Complications
- Hepatitis Viruses Studies and Epidemiology
- Digital Imaging in Medicine
- Adenosine and Purinergic Signaling
- Medical Imaging Techniques and Applications
University of Michigan–Ann Arbor
2022-2024
First Affiliated Hospital of Henan University
2022-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Westlake University
2021-2023
Fudan University
2023
Shanghai Medical College of Fudan University
2016-2023
Johns Hopkins University
2014-2022
Fujian Medical University
2022
Fujian Provincial Hospital
2022
Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates surgical site infection persist.To examine effect intrawound vancomycin powder reducing deep infections.This open-label randomized clinical trial enrolled adult an operatively tibial plateau or pilon fracture who met criteria for a risk from January 1, 2015, through June 30, 2017, 12 months follow-up (final assessments completed April 2018) at 36 US trauma...
Abstract The robust and stable expression of CD38 in T‐cell acute lymphoblastic leukemia (T‐ALL) blasts makes chimeric antigen receptor (CAR)‐T/natural killer (NK) a potential therapy for T‐ALL. However, normal T/NK cells causes fratricide CAR‐T/NK cells. Here “2‐in‐1” gene editing strategy is developed to generate fratricide‐resistant locus‐specific CD38‐specific CAR integrated into the disrupted locus by CRISPR/Cas9, placed under control either endogenous promoter ( KO/KI ) or exogenous...
The impact of the Trauma Collaborative Care (TCC) program on surgeon confidence in managing psychosocial sequelae orthopaedic trauma was evaluated as part a larger prospective, multisite, cluster clinical trial. We compared and perceived resource availability among surgeons practicing centers that implemented TCC with similar did not implement TCC.Prospective cohort design.Level-I centers.Attending fellows (N = 95 Pre N 82 Post).Self-report 10-item measure issues associated support...
Objectives: To determine factors predictive of postoperative surgical site infection (SSI) after fracture fixation and create a prediction score for risk at time initial treatment. Design: Retrospective cohort study. Setting: Level I trauma center. Patients/Participants: Study group, 311 patients with deep SSI; control 608 patients. Intervention: We evaluated 27 theorized to be associated infection. Bivariate multiple logistic regression analyses were used build model. A composite reflecting...
Previous research suggests that the care provided to trauma patients could be improved by including early screening and management of emotional distress psychological comorbidity. The Trauma Collaborative Care (TCC) program, which is based on principles well-established models collaborative care, was designed address this gap in center care. This article describes TCC program design a multicenter study evaluate its effectiveness for improving patient outcomes after major, high-energy...
Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort 198 CRE isolates, isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC 0.5 μg/ml and meropenem, imipenem, doripenem MICs 2 were best able distinguish isolates.
Numerous studies have demonstrated that long-term outcomes after orthopedic trauma are associated with psychosocial and behavioral health factors evident early in the patient's recovery. Little is known about how to identify clinically actionable subgroups within this population.To examine whether risk protective measured at 6 weeks injury could classify individuals into clusters evaluate these explain variations 12-month outcomes.A prospective observational study was conducted between July...
Background: The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is a custom energy-storing carbon fiber ankle-foot orthosis developed for lower-extremity trauma patients. Studies conducted at the military treatment facility where IDEO was demonstrated benefits of when used with Return to Run Physical Therapy (RTR PT) program. current study designed determine if results could be replicated other facilities and examine whether early performance gains in patient-reported functional outcomes...
Abstract T cell genome editing holds great promise to advance a range of immunotherapies but is encumbered by the dependence on difficult‐to‐produce and expensive viral vectors. Here, small double‐stranded plasmid DNA modified mediate high‐efficiency homologous recombination designed. The resulting chimeric antigen receptor (CAR)‐T cells display similar phenotype, transcriptional profile, in vivo potency CAR‐T generated using adeno‐associated vector. This method should simplify accelerate...
Aim The evaluations of handgrip strength (HGS) weakness and asymmetry have implications for the comprehensive geriatric assessment. aim this study was to investigate association HGS on cardiovascular outcomes in older outpatients. Methods This a prospective observational cohort 364 Geriatrics outpatients aged ≥60 years, which all participants carried out tests at baseline. Patients with <28 kg men <18 women were diagnosed as weakness, ratio <0.90 or >1.10 asymmetry. Primary...
Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence CHB infesction and status HBV-related services among pre-conception women will provide insight into risks mother to child transmission (MTCT). A cross-sectional analysis data from National Free Pre-pregnancy Checkups (NFPC) program 2010-2014 was conducted. standardized questionnaire which collected demographic information enzyme-linked immunosorbent assays (ELISA)...
Objective This manuscript describes strategies for assessment of precision several diagnostic artificial intelligence (AI) tools in orthodontics, available open-source image analysis platforms, as well the use three-dimensional (3D) surface models and superimpositions.Results The advances described this present perspectives on controversies whether AI is smarter than clinicians may replace human clinical decisions. A thorough orthodontic diagnosis requires comprehensive 3D interrelationships...
As routine testing of clinical isolates for extended-spectrum β-lactamase (ESBL) production (screen plus phenotypic confirmatory testing) is no longer required by the Clinical and Laboratory Standards Institute (CLSI), a number microbiology laboratories use ceftriaxone MICs as proxy means identifying bacteria potential ESBL producers. Data from 1,386 suggest that MIC cutoff 8 μg/ml an excellent predictor production, with positive predictive value negative approaching 100% 99.5%, respectively.
In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found median <10 µg/mL within first 72 hours may be associated with longer compared ≥10 µg/mL.
CD19-targeting chimeric antigen receptors (CARs) with CD28 and CD3ζ signaling domains have been approved by the US FDA for treating B cell malignancies. Mutation of immunoreceptor tyrosine-based activation motifs (ITAMs) in generated a single-ITAM containing 1XX CAR, which displayed superior antitumor activity leukemia mouse model. Here, we investigated whether design could enhance therapeutic potency against solid tumors. We constructed both CD19- AXL-specific CARs compared their vitro vivo...
Although limb salvage is now possible for many high-energy open fractures and crush injuries to the distal tibia, ankle, hindfoot, midfoot, orthotic options are limited. The Intrepid Dynamic Exoskeletal Orthosis (IDEO) a custom, energy-storing carbon fiber orthosis developed trauma patients undergoing salvage. IDEO differs from other orthoses in that it allows with ankle weakness have more normal biomechanics increased power. This article describes design of study evaluate effectiveness when...
Objective To examine the effects of maternal death on health index child, and educational attainment older children, mental quality life surviving husband. Methods A cohort study including 183 households that experienced a matched to 346 childbirth but not was conducted prospectively between June 2009 October 2011 in rural China. Data household sociodemographic characteristics, physical were collected using quantitative questionnaire medical examination at baseline follow-up surveys....