Abstract The impact of mid-late-life exercise on the aging heart remains unclear, particularly effects high-intensity interval training (HIIT) and continuous moderate-intensity (CMIT). This study was first to examine cardiac function, tissue characteristics, electrical remodeling, mitochondrial morphology homeostasis in old mice subjected CMIT or HIIT, compared untrained controls. Our results showed that 8-week HIIT significantly improved survival rate mice. presented advantages deposition...

Abstract Aim This study aimed to estimate the distribution of and changes in global burden ischaemic heart disease (IHD) attributable high body mass index (BMI) low physical activity (PA) from 1990 2021. Methods Data on deaths, disability‐adjusted life years (DALYs) age‐standardized rates for IHD BMI PA were extracted Global Burden Disease 2021 study. Temporal trends by gender, region Socio‐Demographic Index (SDI) analysed using joinpoint regression. Decomposition, health inequality analysis...

Aim The evaluations of handgrip strength (HGS) weakness and asymmetry have implications for the comprehensive geriatric assessment. aim this study was to investigate association HGS on cardiovascular outcomes in older outpatients. Methods This a prospective observational cohort 364 Geriatrics outpatients aged ≥60 years, which all participants carried out tests at baseline. Patients with <28 kg men <18 women were diagnosed as weakness, ratio <0.90 or >1.10 asymmetry. Primary...

Abstract Background We have witnessed frailty, which characterized by a decline in physiological reserves, become major public health issue older adults. Understanding the influential factors associated with frailty may help prevent or if possible reverse frailty. The present study aimed to investigate status and transition community-dwelling population. Methods A prospective cohort on subjects aged ≥ 60 years was conducted, registered beforehand (ChiCTR 2,000,032,949). Participants who had...

The associations of intrinsic capacity (IC) with dietary diversity and body mass index (BMI) remain unclear in older adults. This study aimed to examine the BMI on high IC. cross-sectional used data from Fujian Prospective Aging Cohort, which included 1972 individuals aged 60–98 2020 2021. score (DDS) was constructed eight food varieties, consuming ≥five varieties daily considered a DDS. grouped into underweight, normal weight, overweight, obesity according Chinese guidelines. High IC...

Abstract Background While physical inactivity or prolonged sitting has been linked to an increased risk of frailty, the interaction between time (ST), activity (PA) and frailty is not well understood. The aim this study was examine dose-response relationship PA, ST further evaluate effect PA on in context regular COVID-19 epidemic prevention control China. Methods A cross-sectional analysis performed 1458 participants (age ≥ 60) enrolled from a prospective cohort elderly people Fujian...

Intrinsic capacity (IC) reflects the overall health status of older adults and has great public significance. But few studies described related biomarkers for IC. The aim this study was to investigate association between homocysteine (Hcy) IC in adults.This cross-sectional included 1927 community-dwelling Chinese aged 60-98 years from May 2020 December 2020. Data were collected through interviews, physical examinations, laboratory tests. involved five domains cognition, locomotion, sensory,...

Abstract Background DD was found to be associated with acute myocardial infarction (AMI) and renal insufficiency. However, it is uncertain whether an independent risk factor of CI-AKI in patients undergoing pPCI. Methods We prospectively enrolled 550 consecutive STEMI pPCI between January 2012 December 2016. The predictive value admission for assessed by receiver operating characteristic (ROC) multivariable logistic regression analysis. defined as absolute serum creatinine increase ≥0.3...

The aim of the study is to evaluate association pre-procedural N-terminal pro-B type natriuretic peptide (NT-proBNP) with contrast-induced acute kidney injury (CI-AKI) and long-term outcomes in elderly patients undergoing elective percutaneous coronary intervention (PCI).A total 540 aged ≥ 75 years who had undergone PCI between January 2012 December 2015 were enrolled this study. Admission NT-proBNP levels measured before PCI. CI-AKI was defined as a relative increase serum creatinine (SCr)...

To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating PI3K-AKT-mTOR signaling pathway.The phenylephrine-induced cardiomyocyte model was established in H9C2 cells vitro. Electroporation transfection technology utilized to prepare and screen inducing low expression angiotensin type one receptor-related protein (Si-APJ). Si-APJ were divided independently into five groups: control group, PE PE+Apelin PE+Rapa PE+Apelin+Rapa group. RT-PCR performed analyze mRNA...

Many studies showed an association between dietary salt intake, blood pressure and increased CVD risk. The potential reason may be related to vascular structural functional changes, through alterations in endothelial function. central retinal arteriolar equivalent urinary albumin reflected dysfunction different part of the body. sodium-creatinine ratio causal urine specimens could represent 24-h sodium intake estimate intake. excretion was estimated by ratio. Urinary albumin-creatinine...

Abstract Background and objectives The associations of intrinsic capacity (IC) with dietary diversity body mass index (BMI) remain unclear in older adults. This study aimed to examine the BMI on high IC. Methods cross-sectional used data from Fujian Prospective Aging Cohort, which included 1972 individuals aged 60-98 2020 2021. score (DDS) was constructed eight food varieties, consuming ≥five varieties daily considered a DDS. grouped into underweight, normal weight, overweight, obesity...

Rest–activity behavior clusters within individuals to form patterns are of significant importance their intrinsic capacity (IC), yet they have rarely been studied. A total 1253 community-dwelling older adults were recruited between July and December 2021 based on the baseline survey database Fujian Prospective Cohort Study Aging. Latent profile analysis was used identify profiles participants rest–activity behaviors, whereas logistic regression carried out investigate relationship IC. We...

Abstract Exercise training can significantly improve skeletal muscle mitochondrial function and has been proven to be highly relevant alterations in DNA methylation. However, it remains unclear whether late-in-life exercise an effect on promoter methylation of PGC-1α, a key regulator biogenesis. Here we employed two distinct modalities, constant medium intensity (CMIT) high-intensity interval (HIIT), investigate their impacts PGC-1α expression regulation aged mice. The results revealed...

To evaluate the prognostic value of ghrelin, a growth hormone-releasing peptide, for mortality and readmission in elderly patients with acute heart failure (AHF).We measured plasma ghrelin pro B-type natriuretic peptide (NT-proBNP) levels upon emergency admission 241 prospectively recruited AHF (61.0% men). The outcomes were all-cause and/or due to (HF). Multivariate Cox proportional hazards regression analyses used ghrelin. Discrimination, calibration, reclassification indices compared...

Abstract Background DD was found to be associated with acute myocardial infarction (AMI) and renal insufficiency. However, it is uncertain whether an independent risk factor of CI-AKI in patients undergoing pPCI.Methods We prospectively enrolled 550 consecutive STEMI pPCI between January 2012 December 2016. The predictive value admission for assessed by receiver operating characteristic(ROC) multivariable logistic regression analysis. defined as absolute serum creatinine increase ≥0.3 mg/dl...

Abstract DD was found to be associated with acute myocardial infarction (AMI) and renal insufficiency. However, it is uncertain whether an independent risk factor of CI-AKI in patients undergoing pPCI.Methods We prospectively enrolled 550 consecutive pPCI between January 2012 December 2016. The predictive value admission for assessed by receiver operating characteristic(ROC) multivariable logistic regression analysis. defined as absolute serum creatinine increase ≥0.3 mg/dl or a relative...

Background The relationship between resting cardiac indices and exercise capacity in older adults was still not well understood. New developments magnetic resonance imaging (MRI) enable a much fuller assessment of characteristics. Purpose/Hypothesis To assess the association specific aspects structure, function, tissue. Study Type Cross‐sectional study. Population A total 112 well‐functioning (mean age 69 years, 52 men). Field Strength/Sequence All participants underwent 3.0 T MRI, using...