A5100428413- Hearing, Cochlea, Tinnitus, Genetics
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Diet and metabolism studies
- Axon Guidance and Neuronal Signaling
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Retinal Diseases and Treatments
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Neurotoxicity Research
- Land Use and Ecosystem Services
- Synthesis and Biological Evaluation
- Diverse Aspects of Tourism Research
- Visual perception and processing mechanisms
- Adipose Tissue and Metabolism
Chinese Academy of Sciences
2007-2025
Kunming Institute of Botany
2023-2025
Columbia University
2023-2025
Columbia University Irving Medical Center
2025
Stanford University
2012-2024
University of Chinese Academy of Sciences
2018-2024
Xinjiang Institute of Ecology and Geography
2022-2024
Nanjing University
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Inner ear hair cells are specialized sensory essential for auditory function. Previous studies have shown that the epithelium is postmitotic, but it harbors can behave as progenitor in vitro, including ability to form new cells. Lgr5 , a Wnt target gene, marks distinct supporting cell types neonatal cochlea. Here, we tested hypothesis + Wnt-responsive precursor In contrast their quiescent vivo behavior, isolated by flow cytometry from EGFP-CreERT2/+ mice proliferated and formed clonal...
Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non-mammalian utricles regenerate HCs via both proliferation and direct transdifferentiation. In adult mammals, limited transdifferentiation from unidentified occurs extrastriolar Type II HCs. Here we show that HC damage in neonatal mouse activates the Wnt target gene Lgr5 striolar supporting cells. Lineage tracing...
The NRF2 pathway activates a cell survival response when cells are exposed to xenobiotics or under oxidative stress. Therapeutic activation of can also be used prior insult as means disease prevention. However, prolonged expression has been shown protect cancer by inducing the metabolism and efflux chemotherapeutics, leading both intrinsic acquired chemoresistance drugs. This effect termed “dark side” NRF2. In an effort combat this chemoresistance, our group discovered first inhibitor,...
Arid regions hold a prominent position as global tourist destination. However, their ecological fragility and sensitivity to economic social factors make them more susceptible various disruptive elements, thereby exacerbating the instability of tourism socio-ecological system. Consequently, there has been growing focus on system resilience (TSESR) in arid regions. This study developed scientific universally applicable assessment framework evaluate TSESR regions, considering system's process...
Atherosclerosis is a chronic lipid-driven inflammatory disease largely influenced by hemodynamics. Neutrophil extracellular trap (NET)-mediated inflammation plays an important role in atherosclerosis. However, little known about the relationship between low shear stress (LSS) and NET generation, as well underlying mechanism.
Permanent hearing loss is caused by the irreversible damage of cochlear sensory hair cells and nonsensory supporting cells. In postnatal cochlea, epithelium terminally differentiated, whereas tympanic border (TBCs) beneath are proliferative. The functions TBCs poorly characterized. Using an Axin2(lacZ) Wnt reporter mouse, we found transient but robust signaling proliferation in during first 3 weeks, when number decreases. vivo lineage tracing shows that a subset derived postnatally from...
Nuclear factor erythroid-2–related 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis coordinating cellular stress responses. They highly homologous transcription factors that regulate the expression of genes bearing antioxidant-response elements (AREs). Genetic ablation NRF1 or results in vastly different phenotypic outcomes, implying they play roles may be differentially regulated. Kelch-like ECH-associated protein (KEAP1) is main negative regulator mediates ubiquitylation...
Utricular hair cells (HCs) are mechanoreceptors required for vestibular function. After damage, regeneration of mammalian utricular HCs is limited and regenerated appear immature. Thus, loss function presumed irreversible. Here, we found partial HC replacement functional recovery in the mature mouse utricle, both enhanced by overexpressing transcription factor Atoh1. Following long-term fate mapping revealed that support non-mitotically modestly displaying no or immature bundles. By...
The nuclear factor (erythroid 2)-like (NRF) transcription factors are a subset of cap'n'collar transcriptional regulators. They consist three members, NRF1, NRF2, and NRF3, that regulate the expression genes containing antioxidant-response elements (AREs) in their promoter regions. Although all NRF members ARE-containing genes, each is associated with distinct roles. A comprehensive study differential overlapping DNA-binding activities NRFs has not yet been conducted. Here, we performed...
The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β subunit, which hydrolyzes cGMP in response to light. This produces cell death more slowly than others caused by loss function, making it particular interest for studying potential therapeutics. We used morphology, biochemistry, and single-cell physiology examine mechanism degeneration. Our results show that no alteration Pde6b RNA but does dramatically decrease maximal basal activity, apparently protein...
Traumatic optic neuropathy (TON) refers to nerve damage caused by trauma, leading partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes nanosized vesicles for the delivery PACAP38 loaded via exosomal...
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we investigate involvement PTMs ketogenic diet (KD)-improved by multi-omics reveal a core target lysine malonylation, acetyl-coenzyme A (CoA) carboxylase 1 (ACC1). ACC1 protein levels Lys1523 malonylation are significantly decreased KD. malonylation-mimic mutant increases its enzyme...
Vertebrate photoreceptors are thought to adapt light by a change in Ca(2+), which is postulated mediate modulation of (1) excited rhodopsin (Rh*) Ca(2+)-dependent binding recoverin, (2) guanylyl cyclase activity via GCAP proteins, and (3) cyclic nucleotide-gated channels Ca(2+)-calmodulin. Previous experiments genetically deleted recoverin the GCAPs showed that significant regulation sensitivity survives removal (2). We channel Ca(2+)-calmodulin site mouse Mus musculus found alters response...
Cyclic-GMP is a second messenger in phototransduction, G-protein signaling cascade that conveys photon absorption by rhodopsin to change current at the rod photoreceptor outer segment plasma membrane. Basal cGMP level strictly controlled opposing actions of phosphodiesterase (PDE6) and retinal guanylyl cyclases (GCs), mutations genes disrupt homeostasis leads degeneration humans through mechanisms are incompletely understood. The purpose this study examine two distinct cellular targets cGMP:...
Chronic inflammatory pain (CIP) frequently coincides with depression among patients. The onset and development of are associated altered neural synaptic plasticity. Electroacupuncture (EA) can effectively relieve CIP depression. However, the underlying mechanisms have not been fully illustrated.
The scientific evaluation of tourism ecological security (TES) is vital for promoting sustainable development and environmental protection. Using the Driver–Pressure–State–Impact–Response model, this study constructed a theoretical framework evaluating TES. An improved Technique Order Preference by Similarity to Ideal Solution method, spatial autocorrelation, standard deviational ellipse center gravity Geographically Temporally Weighted Regression model were used evaluate provincial TES...
The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding its biological relevance limited. Here, we investigated functional role cue SEMA3A supporting PDAC progression.
Mutations that affect calcium homeostasis (Ca2+) in rod photoreceptors are linked to retinal degeneration and visual disorders such as retinitis pigmentosa congenital stationary night blindness (CSNB). It is thought the concentration of Ca2+ outer segments controlled by a dynamic balance between influx via cGMP-gated (CNG) channels extrusion Na+/Ca2+, K+ exchangers (NCKX1). The extrusion-driven lowering [Ca2+]i following light exposure controls their adaptation response termination. Mutant...
Significance Patients with addiction have a greater tendency to engage in risk-taking behavior. However, the neural substrates responsible for these deficits remain unknown. Here we demonstrated that chronic methamphetamine-treated rats preferred high-risk/high-reward actions and assigned higher value high returns, indicative of altered decision-making. Pharmacological studies revealed insular system controls decision-making both healthy rats. We further confirmed role cortex using designer...