A5074191908- Retinal Diseases and Treatments
- Optical Network Technologies
- Advanced Photonic Communication Systems
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Retinoids in leukemia and cellular processes
- Neuroscience and Neuropharmacology Research
- Ocular Diseases and Behçet’s Syndrome
- Semiconductor Lasers and Optical Devices
- Photoreceptor and optogenetics research
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Ocular and Foreign Body Injuries
- interferon and immune responses
- Spectroscopy and Quantum Chemical Studies
- Ocular Infections and Treatments
Wuhan University of Science and Technology
2025
Tianjin Medical University General Hospital
2019-2024
Tianjin Medical University
2020-2024
University of Chinese Academy of Sciences
2020
University of Oklahoma Health Sciences Center
2010-2018
Jiangsu Provincial Academy of Traditional Chinese Medicine
2016-2018
Anhui University of Traditional Chinese Medicine
2018
South China Normal University
2015
Oklahoma City University
2015
Iowa Diabetes and Endocrinology Research Center
2012
The necessity of including both males and females in molecular neuroscience research is now well understood. However, there relatively limited basic biological data on brain sex differences across the lifespan despite age-related neurological dysfunction disease between females. Whole genome gene expression young (3 months), adult (12 old (24 months) male female C57BL6 mice hippocampus was analyzed. Subsequent bioinformatic analyses confirmations changes hippocampal protein were performed....
Intra-retinal extravasation and modification of LDL have been implicated in diabetic retinopathy: autophagy may mediate these effects.Immunohistochemistry was used to detect marker LC3B human murine non-diabetic retinas. Cultured retinal capillary pericytes (HRCPs) were treated with vitro-modified heavily-oxidised glycated (HOG-LDL) vs native (N-LDL) or without modulators: green fluorescent protein-LC3 transfection; small interfering RNAs against Beclin-1, c-Jun NH(2)-terminal kinase (JNK)...
Superparamagnetic iron oxide nanoparticle (SPION) tracers possessing long blood circulation time and tailored for magnetic particle imaging (MPI) performance are crucial the development of this emerging molecular modality.Here, single-core SPION MPI coated with covalently bonded polyethyelene glycol (PEG) brushes were obtained using a semi-batch thermal decomposition synthesis controlled addition oxygen, followed by an optimized PEG-silane ligand exchange procedure.The physical properties,...
Retinal ganglion cell (RGC) death is a hallmark of traumatic optic neuropathy, glaucoma, and other neuropathies that result in irreversible vision loss. However, therapeutic strategies for rescuing RGC loss still remain challenging, the molecular mechanism underlying has not been fully elucidated. Here, we highlight role ferroptosis, non-apoptotic form programmed characterized by iron-dependent lethal lipid peroxides accumulation, using an experimental model glaucoma nerve crush (ONC). ONC...
Traumatic optic neuropathy (TON) refers to nerve damage caused by trauma, leading partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes nanosized vesicles for the delivery PACAP38 loaded via exosomal...
The neovascular form of age-related macular degeneration (nvAMD) is the leading cause blindness in elderly population. Vascular endothelial growth factor (VEGF) plays a crucial role choroidal neovascularization (CNV), and anti-VEGF therapy recommended as first-line for nvAMD. However, many patients do not radically benefit from this therapy. Epidemiological data suggest that physical exercise beneficial human diseases, including Yet, its protective mechanism therapeutic potential remain...
We previously showed that extravasated, modified LDL is implicated in pericyte loss diabetic retinopathy (DR). Here, we investigate whether induces apoptosis retinal Müller glial cells.Cultured human cells (MIO-M1) were treated with highly oxidized glycated (HOG-LDL, 200 mg protein/L) or native (N-LDL, for up to 24 hours without pretreatment N-acetyl-cysteine (NAC, a blocker of oxidative stress) and 4-phenylbutyrate (4-PBA, endoplasmic reticulum [ER] stress). Effects HOG-LDL on cell...
Ginsenoside compound K (CK) is one of the effective ingredients in antitumor composition ginsenoside. However, poor water solubility and significant efflux have limited widespread clinical use CK. In this study, preparation novel CK-loaded d-alpha-tocopheryl polyethylene glycol 1,000 succinate/poly(ethylene glycol)-poly(ε-caprolactone) mixed micelles (CK-M) discussed to solve above problems. Particle size, zeta potential, morphology were characterized using dynamic light scattering...
Recently it has been shown that levels of circulating oxidized LDL immune complexes (ox-LDL-ICs) predict the development diabetic retinopathy (DR). This study aimed to investigate whether ox-LDL-ICs are actually present in retina, and define their effects on human retinal pericytes versus ox-LDL. In sections from people with type 2 diabetes, costaining for ox-LDL IgG was present, proportionate DR severity, detectable even absence clinical DR. contrast, no such staining observed retinas...
Metabolic disorder significantly contributes to diabetic vascular complications, including retinopathy, the leading cause of blindness in working-age population. However, molecular mechanisms by which disturbed metabolic homeostasis causes dysfunction retinopathy remain unclear. O-GlcNAcylation modification acts as a nutrient sensor particularly sensitive ambient glucose. Here, we observe pronounced O-GlcNAc elevation retina endothelial cells patients and mouse models. Endothelial-specific...
At present, there is unclear on the risk factors of recurrence after myomectomy. In this study, we hope to provide reference for choice treatment patients with uterine fibroids and basis subsequent prediction recurrence. From October 2020 2022, enrolled 240 in Hubei Maternal Child Health Hospital. According inclusion criteria, collected clinical data these were analyzed divided into 2 groups according whether was 6 months surgery(a group [52 cases] a non-recurrence [78 cases]). We compared...
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and gating kinetics thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown. Here we find that prototypical member of family, stargazin or γ-2, rescues deficits in AMPARs carrying mutations destabilize closed-cleft states ligand-binding domain (LBD), suggesting reverses these likely stabilizes closed LBD...