A5013431604- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- Medicinal Plant Extracts Effects
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Neurological Disease Mechanisms and Treatments
- Vitamin D Research Studies
- Coenzyme Q10 studies and effects
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- interferon and immune responses
- Mitochondrial Function and Pathology
- Traditional and Medicinal Uses of Annonaceae
- Ginseng Biological Effects and Applications
- Cynara cardunculus studies
- CAR-T cell therapy research
- Flavonoids in Medical Research
- Systemic Lupus Erythematosus Research
- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
University at Buffalo, State University of New York
2023-2025
New York University
2024
Tianjin University of Traditional Chinese Medicine
2020-2023
Jacobs (United States)
2023
Noguchi Memorial Institute for Medical Research
2022
University of Ghana
2022
The Vitamin D receptor (VDR) is a crucial nuclear that plays vital role in various physiological functions. To larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin or synthetic analogs to treat non-communicable diseases insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) bioactive compounds derived from natural sources...
Suxiao Jiuxin Pill (SJP) is a well-known traditional Chinese medicine drug used to manage heart diseases. This study aimed at determining the pharmacological effects of SJP in acute myocardial infarction (AMI), and molecular pathways its active compounds target induce coronary artery vasorelaxation. Using AMI rat model, improved cardiac function elevated ST segment. LC-MS GC-MS detected twenty-eight non-volatile eleven volatile sera from SJP-treated rats. Network pharmacology analysis...
Protein-ligand interactions play a pivotal role in drug discovery and understanding biological processes. Structural biology techniques, such as X-ray crystallography, offer atomic-level insights into these static environment. solution scattering (XSS) is valuable tool for studying proteins due to its ability provide low-resolution structural information complementary high-resolution it can be performed high throughput at modern sources. In this presentation, we describe our algorithm called...
Shenmai injection (SMI) has been used in the treatment of cardiovascular disease (CVD), such as heart failure, myocardial ischemia and coronary disease. It found to have efficacy on doxorubicin (DOX)-induced cardiomyopathy. The aims this study were explore underlying molecular mechanisms SMI CVD by using network pharmacology its protective effect DOX-induced cardiotoxicity vitro vivo experiment based prediction.Network method was reveal relationship between ingredient-target-disease...
Malaria continues to be a major public health concern, particularly for children and pregnant women in areas where the disease is endemic. Developing safe efficient antimalarial therapies fight essential. Medicinal plants represent potential source development of new drugs. Tetrapleura tetraptera plant native West Africa traditionally used treat several diseases including Malaria. Here, we investigated antiplasmodial activities T. fruit extracts against chloroquine-sensitive (Pf3D7)...
Recent studies have demonstrated that the essential oil of Nardostachys jatamansi (EONJ) has potential health benefits, such as reducing blood pressure, protecting heart, and relaxing vessels. However, active constituents underlying molecular mechanisms are still unclear. In this study, we utilized GC–MS to identify chemical EONJ tested its vasodilatory effects on constricted isolated thoracic aorta rings from mice. We then combined network pharmacology with spectrum-effect relationship...
shows dual hepatoprotective and hepatotoxic effects. The bioactive components responsible for these effects are unknown. This study investigates whether
In recent years, the spread of coronavirus disease 2019 (COVID-19) in China has been effectively controlled by implementing national prevention and control measures. However, a large number recovered patients are plagued fatigue, whether acute or chronic, other fatigue-related syndromes that severely affect their quality life. Post-viral fatigue syndrome (PVFS) is widespread chronic neurological with no definite etiological factor(s), definitive diagnostic test, approved pharmacological...